Variation of cost among anti-malarial drugs available in Indian market

Abstract

Background: There are numerous brands of antimalarial existent in the market. Expensive drugs could result in financial drain that causes reduced compliance or even non-compliance. Non-adherence to therapy could consequently cause partial treatment that leads to higher morbidity and in certain cases mortality too. Thus this evaluation was conducted to measure the cost disparity of malaria therapy.Methods: The maximum and minimum price of each brand of the drug in Indian rupee rate was noted by using the latest edition of current index of medical specialities. The cost ratio and the percentage cost variation for individual drug brands were calculated.Results: The analysis of data reflected a considerable cost variation among antimalarial drugs. Chloroquine DS 500 mg showed the highest cost ratio and cost variation (cost ratio=15.3 and % cost variation=1434). Overall injectable antimalarials showed considerable cost variation as compared to oral antimalarial agents.Conclusions: The maximum variation shown by oral antimalarial was found to be for chloroquine DS 500 tablet. But there was significant price variation among injectable antimalarial. Injectable antimalarials are often the choice of drug when dealing with critically ill malaria patients specially when suffering from complicated malaria. So, such significant price variation creates burden on poor patients economically which leads to non-compliance and hence increased morbidity and mortality due to incomplete treatment.

A Pharmacoeconomic Outlook of the Biological Drugs Marketed in India: A Cost Variance Analysis

“…Once the cost ratio exceeds two and the cost variation goes above 100%, the cost deviation is significant [17]. Out of the 23 different formulations analyzed, 10 formulations showed a variation greater than 100% in the maximum and minimum prices.…”

“…Moreover, in our study, the cost variation of streptokinase 1,500,000 IU was 107.33%, while the study by Ray A et al [ 14 ] showed 132.02%. Once the cost ratio exceeds two and the cost variation goes above 100%, the cost deviation is significant [ 17 ]. Out of the 23 different formulations analyzed, 10 formulations showed a variation greater than 100% in the maximum and minimum prices.…”