Variation of docosahexaenoic acid content in subsets of human spermatozoa at different stages of maturation: Implications for sperm lipoperoxidative damage

Ollero, Mario; Powers, Robert D.; Álvarez, Juan G.

doi:10.1002/(sici)1098-2795(200003)55:3<326::aid-mrd11>3.0.co;2-a

Cited by 80 publications

(15 citation statements)

References 46 publications

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“…For example, the cytoplasmic droplet on human spermatozoa is associated with poor sperm motility (Zini, et al, 1998), abnormal head and midpiece morphology (Gergely, et al, 1999, Gomez, et al, 1996, Huszar and Vigue, 1993, lower fertilizing capacity (Keating, et al, 1997) and reduced zona pellucida binding (Ergur, et al, 2002, Huszar, et al, 1994, Liu and Baker, 1992. The mechanism by which these abnormal sperm exhibit reduced function is attributed to disturbed membrane remodeling (Huszar, et al, 1997) and higher extents of lipid peroxidation (Aitken, et al, 1994, Huszar, et al, 1994, Ollero, et al, 2000. The latter is most likely due to the high levels of ROS produced by the cytoplasmic droplet itself (Aitken, et al, 1994, Gil-Guzman, et al, 2001, Gomez, et al, 1996, Huszar and Vigue, 1993, Ollero, et al, 2000, combined with the enriched polyunsaturated fatty acids derived from the membrane of the droplet Vigue, 1993, Ollero, et al, 2000).…”

Section: Spermatogenesismentioning

confidence: 99%

“…The mechanism by which these abnormal sperm exhibit reduced function is attributed to disturbed membrane remodeling (Huszar, et al, 1997) and higher extents of lipid peroxidation (Aitken, et al, 1994, Huszar, et al, 1994, Ollero, et al, 2000. The latter is most likely due to the high levels of ROS produced by the cytoplasmic droplet itself (Aitken, et al, 1994, Gil-Guzman, et al, 2001, Gomez, et al, 1996, Huszar and Vigue, 1993, Ollero, et al, 2000, combined with the enriched polyunsaturated fatty acids derived from the membrane of the droplet Vigue, 1993, Ollero, et al, 2000). The plasma membrane remodeling event involves the formation of zona pellucida binding sites via protein transport, which is thought to be mediated by the molecular chaperone, HSPA2.…”

Section: Spermatogenesismentioning

confidence: 99%

See 1 more Smart Citation

More Than a Simple Lock and Key Mechanism: Unraveling the Intricacies of Sperm-Zona Pellucida Binding

Redgrove¹,

Aitken²,

Nixon³

2012

Binding Protein

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Section: Spermatogenesismentioning

confidence: 99%

Section: Spermatogenesismentioning

confidence: 99%

More Than a Simple Lock and Key Mechanism: Unraveling the Intricacies of Sperm-Zona Pellucida Binding

Redgrove¹,

Aitken²,

Nixon³

2012

Binding Protein

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“…Ils sont généralement sous forme d'esters associés à la partie polaire des lipides ( [5,11,18,27]. Alors que, chez l'homme et le bélier, on retrouve de fortes quantités de DHA mais pas du tout de DPA [13,16,29]. À l'inverse, la membrane plasmique du spermatozoïde de rat contient une forte quantité de DPA, mais pas de DHA.…”

Section: Ag Membranaires Et Spermatozoïdeunclassified

Changes in spermatozoa plasma membrane lipid composition during epididymal maturation

Rejraji¹,

Saez

Drevet

2009

Basic Clin. Androl.

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Un des aspects de la maturation posttesticulaire des spermatozoïdes chez les mammifères est l'évolution progressive de la composition lipidique de la membrane plasmique des gamètes mâles qui permet à ces derniers d'acquérir des capacités fusogènes particulières détermi-nantes pour la fécondation. Une part importante de cette modification du contenu lipidique de la membrane des gamètes mâles est assurée lors de la descente des spermatozoïdes dans le tubule épididymaire. Les mouvements lipidiques seront ensuite poursuivis dans les voies génitales femelles au cours d'un processus dynamique, la capacitation, étape préalable indispensable à la réaction acrosomique, et donc, à la fécondation. Cette revue fait l'état des lieux des connaissances acquises par divers groupes de recherche dans le premier volet épididymaire de la maturation lipidique des gamètes mâles dans différents modèles de mammifères.Abstract One aspect of mammalian post-testicular sperm maturation is the progressive change in their plasma membrane lipid composition. These modifications in lipids allow sperm cells to fuse with oocytes during fertilization. A significant share of these sperm lipid changes occurs during their descent through the epididymal tubule. It then continues within the female genital tract during the capacitation process, an essential prerequisite for acrosomic reaction and hence fertilization. This review presents what is known concerning the sperm plasma membrane lipid changes during epididymal maturation in various mammalian models. In the first section, after a brief presentation of the classic eukaryotic cell plasma membrane lipid organization, the emphasis is on the particularities of sperm plasma membrane lipids. The second section presents the different changes occurring in the three major classes of lipids (i.e. phospholipids, sterols and fatty acids) during the sperm's epididymal descent. The final section briefly describes the mechanisms by which these lipid changes might happen in the epididymal lumen environment. The role played by lipid-rich vesicles secreted by the epididymal epithelium via apocrine secretory processes is highlighted.

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“…Cryopreservation affects the lipid architecture of plasma membrane [1 and] and metabolism due to the high amount of polyunsaturated fatty acids (PUFAs) with significantly less cytoplasmic components containing antioxidants [2]. The PUFAs plays an important role in regulating sperm membrane fluidity and spermatogenesis [3]. Alteration of the membrane fluidity during freezing-thawing processes will cause accumulation of calcium ion which consequently impaired sperm motility and eventually endanger the sperm survival [4].…”

Section: Introductionmentioning

confidence: 99%

Influence of Adding Manganese to Tris Extender on some Post-Cryopreservation Semen Attributes of Holstein Bulls

Eidan¹

2015

IJAAS

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Abstract:This study was conducted to explore the adding effect of manganese (Mn +2 ) to Tris extender on post cooling and cryopreservation semen attributes of Holstein bulls for different periods. Seven Holstein bulls of 3.5-4.5 years old were used in this study. Pooled semen was divided into three groups. The first group was diluted with Tris only (control group, G1). While the 2 nd (G2) and 3 rd (G3) groups were added 0.7 and 0.9 mM Mn +2 respectively. The effect of these additions on Holstein bulls semen quality was studied during different periods (cooling at 5 Celsius, 72 hrs.,1 st , 2 nd and 3 rd post cryopreservation, PC). Addition of Mn +2 led to significant increases of total ( ×10 6 ) plasma membrane integrity of sperms and total function sperm fraction as compared with control groups during cooling and PC periods. It can be concluded that the addition two levels of acid Mn +2 led to enhanced PC semen quality of bulls. This will in turn improved fertility rate of cows and owner's economic income.

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Variation of docosahexaenoic acid content in subsets of human spermatozoa at different stages of maturation: Implications for sperm lipoperoxidative damage

Cited by 80 publications

References 46 publications

More Than a Simple Lock and Key Mechanism: Unraveling the Intricacies of Sperm-Zona Pellucida Binding

More Than a Simple Lock and Key Mechanism: Unraveling the Intricacies of Sperm-Zona Pellucida Binding

Changes in spermatozoa plasma membrane lipid composition during epididymal maturation

Influence of Adding Manganese to Tris Extender on some Post-Cryopreservation Semen Attributes of Holstein Bulls

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