The COVID-19 pandemic has had a major impact on various sectors. Iran is one of the countries most affected by this pandemic. After considering the huge impact, the government imposed strict rules prohibiting social gatherings and restricting travel for the entire population following the large number of victims in the country. These restrictions lead to changes in the environment, especially air quality. The purpose of this study was to find out how the COVID-19 pandemic affected air quality in Iran following the activity restrictions in the region. The method used in this research was based on the use of multitemporal Sentinel-5P data processing with scripts available on the Google Earth Engine applied on the images, acquired in the period before and after the COVID-19 pandemic. The data used included the image collection of Sentinel-5P NRTI CO: Near Real-Time Carbon Monoxide, Sentinel-5P NRTI NO2: Near Real-Time Nitrogen Dioxide and Sentinel-5P NRTI SO2: Near Real-Time Sulphur Dioxide. The results showed, that for Iran in general, changes in the concentration of CO are clearly visible in urban areas with high population activity such as Tehran, where there was a decrease from 0.05 to 0.0286 mol/m2, while for other areas it is also influenced by the varying climate conditions, which affect the level of pollution. For the NO2 pollutant, there was a significant decrease in pollution levels in big cities such as Tehran, Qom, Isfahan and Mashhad from 0.0002 to 0.000114 mol/m2. For the SO2 pollutant, there was a decrease in pollution levels in Iran’s big cities from 0.0005 to 0.0000714 mol/m2. For Tehran province, which is the most populous and busiest province in Iran, it can be observed that there was also a decrease in the concentration of pollutants after the lockdown compared to the pre-lockdown period. The CO concentration decreased from 0.043 to 0.036 mol/m2, while for the NO2 pollutant there was a decrease from 0.0002 to 0.000142 mol/m2 and for the SO2 pollutant, there was a decrease from 0.0005 to 0.000143 mol/m2.