Variation of Platelet Indices among Patients with Diabetes Mellitus Attending Tertiary Care Hospital

Dwivedi, Tanima; Davangeri, Reshma

doi:10.7860/jcdr/2018/36486.12306

Cited by 7 publications

(14 citation statements)

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“…In agreement with Dwivedi et al 10 and Buch et al 5 studies, this study showed that platelet count was lower in patients with microvascular complications than those without microvascular complications but it was not statistically significant. One possible explanation for the decreased in platelet counts in participants with microvascular complications was centered on the rapid consumption of activated platelets in diabetics with complications.…”

Section: Discussionsupporting

confidence: 91%

“…After adjusting for potential confounders in multivariate logistic regression, increases in MPV, PDW, and P-LCR levels were significantly associated with the presence of microvascular complications. This was in accordance with studies conducted by Desai et al, 17 Tanima Dwivedi and Reshma Davangeri, 10 Sushma K and Rangaswamy M, 18 Walinjkar et al, 19 Pujani et al, 20 and Shilpi et al 21 …”

Section: Discussionsupporting

confidence: 90%

“…Hyperactive platelets are larger, highly active, and releases more granules and hence causing increased coagulation, impaired fibrinolysis, and endothelial dysfunction thereby increases the pathogenesis of vascular complications. 10 , 17 In addition, these hyperactive platelets are transformed into the multi-pseudopodia structure and become potentially liable for adhesion and adherence which leads to vascular complications. 31 …”

Section: Discussionmentioning

confidence: 99%

“…Hence, platelet indices which commonly available from the routine hematological analysis may provide important information for early detection and evaluation of diabetes-related complications so that timely intervention could be taken from earlier stages. 10 …”

Section: Introductionmentioning

confidence: 99%

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Platelet Indices and Its Association with Microvascular Complications Among Type 2 Diabetes Mellitus Patients in Northeast Ethiopia: A Cross-Sectional Study

Taderegew¹,

Woldeamanuel²,

Emeria³

et al. 2021

DMSO

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Purpose Platelet indices have been shown to be associated with complications of diabetes mellitus (DM). However, the clinical relevance of platelet indices for assessing the risk of being microvascular complications among patients with DM is largely overlooked. Hence this study aimed to determine the association of platelet indices with microvascular complications among type 2 DM patients. Patients and Methods A hospital-based cross-sectional study was conducted among 352 type 2 DM patients from April 1 to May 30/2019 at Debre Berhan Referral Hospital. Data were collected by interview, physical measurements, document review, and laboratory tests. Then the data were entered into Epi-data manager-4.4.1.0 and exported into SPSS-25 for analysis. Platelet indices were compared between participants with and without microvascular complications using an independent t -test. A logistic regression model was used to assess the association between microvascular complications and platelet indices. All inferences were considered statistically significant at P<0.05. Results One hundred seventeen (33.2%) of participants were suffering from at least one microvascular complications. The mean platelet volume (MPV), platelet distribution width (PDW), and platelet-large cell ratio (P-LCR) were significantly increased in DM patients with complications as compared to without complications (13.57±2.17fl vs. 11.76±1.93fl), (16.57±2.49fl vs. 14.97±2.41fl) and (28.09±7.58% vs. 24.19±6.46%), respectively (all are P˂0.001). In multivariate logistic regression analysis, MPV (AOR=1.68, 95% CI: 1.37–2.05), PDW (AOR=1.37, 95% CI: 1.15–1.63), P-LCR (AOR=1.07, 95% CI: 1.01–1.14), age (AOR=1.07, 95% CI: 1.01–1.12), and duration of DM (AOR=1.31, 95% CI: 1.18–1.46) were significantly associated with the presence of microvascular complications. Conclusion MPV, PDW, and P-LCR were significantly higher among type 2 DM patients with microvascular complications. This indicates that platelet indices can be used as prognostic markers of vascular complications and can be used as simple and cost-effective parameters to predict microvascular complications particularly in patients with old age and long duration of DM.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Platelet Indices and Its Association with Microvascular Complications Among Type 2 Diabetes Mellitus Patients in Northeast Ethiopia: A Cross-Sectional Study

Taderegew¹,

Woldeamanuel²,

Emeria³

et al. 2021

DMSO

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“…Increased MPV levels are associated with increased mortality in patients with coronary artery disease (9) and linked to an increased risk of coronary artery disease in hemodialysis patients (10). Platelet indices have also shown evidence for the early detection and assessment of diabetes (11) and in the study of thrombocytopenia (12). Leukocyte and platelet counts are measured during diagnosis to determine the (BCR-ABL) copy type, which identifies a distinct phenotypic and biological condition (13).…”

Section: Introductionmentioning

confidence: 99%

A comparison of platelet indices in children with urinary tract and tonsillitis infection

Hussain¹

2023

Biomedicine

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Introduction and Aim: Platelet indices are used as diagnostic markers in many diseases and disorders. Urinary tract infections and tonsillitis are common among children. In this study we aimed to investigate whether platelet indices could be used as a marker of UTI and tonsillitis in children. Materials and Methods: This study included 120 children aged between 1-10 years, who were divided into 3 groups (G1-G3). The group G1 included children suffering from UTI (n=40), G2 with only tonsillitis (n=40) and G3 only healthy children (n=40). UTI and tonsillitis were diagnosed based on different parameters including C - reactive protein, erythrocyte sedimentation rate and complete blood counts. The platelet indices (PLT count, MPV, PDW, PCT, P-LCR, P-LCC) were measured using an automatic CBC blood counting and analysis machine. Results: The results in this study showed a high significant increase in (127.22), (7.179), (0.122) platelet count, PDW % and PCT% respectively and non-significant increase of P-LCC count. The results also revealed a high significant decrease in values of MPV, PDW and P-LCR (2.210), (2.315) and (6.427) respectively. Conclusion: Our study suggests the platelet indices could be used as a diagnostic marker in diagnosing urinary tract infection and tonsillitis in children.

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Role of mean platelet volume in patients with type 2 diabetes mellitus

Thakur¹,

Adhikari²,

Dahal³

et al. 2023

IJPO

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In type 2 diabetes mellitus, increased platelet activity is crucial for the emergence of vascular complications. Mean platelet volume (MPV), an indicator of enhanced platelet activity, may be helpful in identifying the thromboembolic events that lead to these vascular complications. This study aims to assess MPV in Type 2 Diabetes patients and investigate the relationship between MPV and glycaemic and diabetic complications. : A comparative cross-sectional study was carried out on 266 subjects (133 diabetic patients and 133 nondiabetic controls) at B.P Koirala Institute of Health Sciences for a period of one year. MPV was analyzed in both the groups and the potential association of MPV with diabetic complications and glycaemic parameters was evaluated. Statistical analysis was carried out with Student t-test and Pearson Correlation Coefficient.: The results of the study showed that diabetics' MPV was considerably higher than that of non-diabetic controls (10.07 + 1.41 vs. 7.47 + 0.60 fl, P0.001) and that diabetic patients who had complications had significantly higher MPV than those who did not (10.61 + 1.35 vs. 9.37 + 1.15 fl, P0.001). Retinopathy (p=0.004), nephropathy (p=0.001), and Peripheral artery disease (p=0.03) were diabetes complications with significantly increased MPV. With regard to HbA1C, FBS levels, and the duration of diabetes, MPV demonstrated a statistically significant positive connection (p0.001 and positive r-value).: MPV is a cost-effective tool in the early detection of vascular complications in diabetes and hence proves to be a promising indicator in preventing vascular complications.

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Variation of Platelet Indices among Patients with Diabetes Mellitus Attending Tertiary Care Hospital

Cited by 7 publications

References 0 publications

Platelet Indices and Its Association with Microvascular Complications Among Type 2 Diabetes Mellitus Patients in Northeast Ethiopia: A Cross-Sectional Study

Platelet Indices and Its Association with Microvascular Complications Among Type 2 Diabetes Mellitus Patients in Northeast Ethiopia: A Cross-Sectional Study

A comparison of platelet indices in children with urinary tract and tonsillitis infection

Role of mean platelet volume in patients with type 2 diabetes mellitus

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