Variation of trabecular architecture in proximal femur of postmenopausal women

Ascenzi, Maria-Grazia; Hetzer, Nicole; Lomovtsev, Alexandre; Rude, Robert K.; Nattiv, Aurelia; Favia, A

doi:10.1016/j.jbiomech.2010.10.017

Cited by 16 publications

(6 citation statements)

References 66 publications

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“…Loads and resulting strains in bone are transferred through the trabecular tissue, which has been optimized to the local mechanical loading demands through remodeling 13 . Locally, the primary orientation of the trabeculae is aligned with the global main force direction 7 , while secondary oriented trabeculae complete the optimized network of the tissue 14 . The forces deform the trabecular structure in such a way that individual trabeculae endure strains that can be compressive, tensile, or in shear, depending on the direction of the load and the trabecular network.…”

Section: Introductionmentioning

confidence: 99%

Sub-trabecular strain evolution in human trabecular bone

Turunen

Cann

Tudisco

et al. 2020

Sci Rep

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To comprehend the most detrimental characteristics behind bone fractures, it is key to understand the material and tissue level strain limits and their relation to failure sites. The aim of this study was to investigate the three-dimensional strain distribution and its evolution during loading at the subtrabecular level in trabecular bone tissue. Human cadaver trabecular bone samples were compressed in situ until failure, while imaging with high-resolution synchrotron radiation X-ray tomography. Digital volume correlation was used to determine the strains inside the trabeculae. Regions without emerging damage were compared to those about to crack. Local strains in close vicinity of developing cracks were higher than previously reported for a whole trabecular structure and similar to those reported for single isolated trabeculae. Early literature on bone fracture strain thresholds at the tissue level seem to underestimate the maximum strain magnitudes in trabecular bone. Furthermore, we found lower strain levels and a reduced ability to capture detailed crack-paths with increased image voxel size. This highlights the dependence between the observed strain levels and the voxel size and that high-resolution is needed to investigate behavior of individual trabeculae. Furthermore, low trabecular thickness appears to be one predictor of developing cracks. In summary, this study investigated the local strains in whole trabecular structure at sub-trabecular resolution in human bone and confirmed the high strain magnitudes reported for single trabeculae under loading and, importantly extends its translation to the whole trabecular structure. Bone can withstand particularly high loads. For example, at the organ level the human proximal femur can endure up to 10 times the bodyweight 1-4. Bone strength is provided both by the material and its heterogeneous hierarchical structure in which each length scale has its important role 5. At the tissue level, the forces are distributed and transferred through the bone based on the relations between the spongy trabecular network and the dense cortical bone. Trabecular bone is metabolically highly active and undergoes remodeling throughout life 6-8. During aging and when affected by metabolic bone diseases such as osteoporosis, the metabolic activity changes as bone turnover is increased 5, 6, 9. These alterations result in net-loss of bone tissue, with decreased structural connectivity and apparent density, which subsequently leads to a weaker structure. To understand the most detrimental characteristics behind bone fractures, it is important to investigate the fracture initiation and find the relationships between failure sites and measurable bone parameters. Many studies utilize computational finite element analysis to investigate the local bone strains during loading 10-12. However, such studies are restricted because of limited experimental data available for validation. The lack of direct experimental measurements of the evolution of strains in bone during loading until failure ...

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Section: Introductionmentioning

confidence: 99%

Sub-trabecular strain evolution in human trabecular bone

Turunen

Cann

Tudisco

et al. 2020

Sci Rep

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“…Current micro-CT-based analyses of trabecular bone characterize its organization in terms of textural structural features within a region of interest [mean trabecular thickness (Tb.Th), mean inter-trabecular distance, bone volume-total volume ratio (BV/TV), and degree of anisotropy (DA)] (Odgaard, 1997;Bouxsein et al, 2010). BV/TV and Tb.Th parameters significantly account for the tissue stiffness and strength (Ascenzi et al, 2011). A higher DA was found to contribute to trabecular bone strength in the case of non-uniform stress by leveling out local strains (Bayraktar and Keaveny, 2004).…”

Section: Introductionmentioning

confidence: 94%

3D Architecture of Trabecular Bone in the Pig Mandible and Femur: Inter-Trabecular Angle Distributions

et al. 2017

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Cancellous bone is an intricate network of interconnected trabeculae, to which analysis of network topology can be applied. The inter-trabecular angle (ITA) analysis-an analysis of network topological parameters and regularity of network-forming nodes-was previously carried out on human proximal femora and showed that trabecular bone follows two main principles: sparsity of the network connectedness (prevalence of nodes with low connectivity in the network) and maximal space spanning (angular offset of connected elements is maximal for their number and approximates the values of geometrically symmetric shapes). These observations suggest that 3D organization of trabecular bone, irrespective of size and shape of individual elements, reflects a tradeoff between minimal metabolic cost of maintenance and maximal network stability under conditions of multidirectional loading. In this study, we validate the ITA application using additional 3D structures (cork and 3D-printed metal lattices), analyze the ITA parameters in porcine proximal femora and mandibles, and carry out a spatial analysis of the most common node type in the porcine mandibular condyle. The validation shows that the ITA application reliably detects designed or evolved topological parameters. The ITA parameters of porcine trabecular bones are similar to those of human bones. We demonstrate functional adaptation in the pig mandibular condyle by showing that the planar nodes with three edges are preferentially aligned in relation to the muscle forces that are applied to the condyle. We conclude that the ITA topological parameters are remarkably conserved, but locally do adapt to applied stresses.

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“…Однак існує й інша причина зниження мінеральної щільності кісткової тканини (МЩКТ) -остео-маляція (ОМ), яка також супроводжується зменшенням міцності кісткових структур і зростанням ризику переломів у міру розвитку процесу [5][6][7]. При цьому, незважаючи на однаковий клінічний результат (переломи), морфоструктурні, етіологічні та патогенетичні характеристики ОП та ОМ різняться якісно [8][9][10].…”

Section: вступunclassified

Morphological and morphometric changes of bone tissue in patients with osteoporosis and osteomalation

Іgnatiev

Turchyn

Ulianov

et al. 2022

TRAUMA

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Bone tissue was studied in 56 postmenopausal women (mean age 62.30 ± 2.74 years), of which 46 patients who worked in unfavorable working conditions had a decreased bone mineral density (BMD) (osteoporosis (OP) — in 31 women, osteomalacia (OM) — in 13); 10 women had no metabolic changes in bone tissue (BT). A BT scan fragment was obtained during surgery for a fracture of the femoral neck. Non-decalcified QD sections were prepared, the functional activity of the QD cell nuclei was determined using the method of differential staining of nuclei with different functional activity. Morphological changes in OP and OM have both common features and differences. The common is the thinning of the bone rods, the expansion of the canals of osteons, the presence of cell-free areas, and cell-free lacunae. In contrast to OP, OM presents with the thickness and area of the osteoid increase, a less pronounced decrease in oxyphyllin matrix, a higher functional activity of BT cells. A decrease in BMD and the occurrence of low-energy fractures may result not only from OP but also OM. When prescribing treatment, it is necessary to carry out diffe-rential diagnostic measures that determine the cause of the decrease in bone mass.

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Variation of trabecular architecture in proximal femur of postmenopausal women

Cited by 16 publications

References 66 publications

Sub-trabecular strain evolution in human trabecular bone

Sub-trabecular strain evolution in human trabecular bone

3D Architecture of Trabecular Bone in the Pig Mandible and Femur: Inter-Trabecular Angle Distributions

Morphological and morphometric changes of bone tissue in patients with osteoporosis and osteomalation

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