“…46,47 For example, Birkmeyer et al showed the ratio of the highest to the lowest hospital referral regions for carotid endarterectomy for Medicare enrollees in the USA to be approximately 10 to 1. 46 Variation based on differences between patients is appropriate, but this variation was not explained by case mix or even by differences in resource. Instead, variation of this type seems typically to reflect regional differences in the approach of providers, 46,48 although prejudice on one hand and patient preferences on the other may also be factors.…”