2010
DOI: 10.1109/tmi.2009.2036258
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Variational Image Segmentation for Endoscopic Human Colonic Aberrant Crypt Foci

Abstract: The aim of this paper is to introduce a variational image segmentation method for assessing the aberrant crypt foci (ACF) in the human colon captured in vivo by endoscopy. ACF are thought to be precursors for colorectal cancer, and therefore their early detection may play an important clinical role. We enhance the active contours without edges model of Chan and Vese to account for the ACF's particular structure. We employ level sets to represent the segmentation boundaries, and discretize in space by finite el… Show more

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Cited by 16 publications
(15 citation statements)
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“…169 In the last three decades, induction of aberrant crypt foci (ACF) in rat colon has been widely accepted as the pre-neoplastic lesions for modeling colorectal cancer. [172][173][174][175][176][177] Although 2 studies showed that senna promoted formation of carcinogen-induced ACF in rat colon when given at high doses, 178,179 other studies failed to show any effects of senna in initiating ACF per se or promoting existing ACF. 180,181 In fact, one study even demonstrated a reduction of ACF in rat colon after long-term usage of senna.…”
Section: Fluidsmentioning
confidence: 99%
“…169 In the last three decades, induction of aberrant crypt foci (ACF) in rat colon has been widely accepted as the pre-neoplastic lesions for modeling colorectal cancer. [172][173][174][175][176][177] Although 2 studies showed that senna promoted formation of carcinogen-induced ACF in rat colon when given at high doses, 178,179 other studies failed to show any effects of senna in initiating ACF per se or promoting existing ACF. 180,181 In fact, one study even demonstrated a reduction of ACF in rat colon after long-term usage of senna.…”
Section: Fluidsmentioning
confidence: 99%
“…Basically there are two directions for improvement which deal with the limitations of the original Chan-Vese model. The first one is to employ more complicated and flexible probabilistic region models [3], [10], [20], [22], [28], [40]. Another direction is to use texture features [40], [42], [43] to detect the texture-induced edges.…”
Section: Related Workmentioning
confidence: 99%
“…The total energy incorporating both the boundary and the region based information is then defined by (20) The first term is the boundary-based force where the boundary classification information is incorporated. The second term is the region-based force where the region classification information is incorporated.…”
Section: Unifying Region and Boundary-based Informationmentioning
confidence: 99%
“…They assumed that polyps appear as convex objects in a image, and introduced active rays to obtain a smoother contour. Figueiredo et al [19] proposed a segmentation method for assessing the aberrant crypt foci captured by an endoscope. They used variational level sets and active contours without the edge model of Chan and Vase [20].…”
Section: Related Workmentioning
confidence: 99%