2009
DOI: 10.1016/j.neuro.2009.01.004
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Variations at a quantitative trait locus (QTL) affect development of behavior in lead-exposed Drosophila melanogaster

Abstract: We developed Drosophila melanogaster as a model to study correlated behavioral, neuronal and genetic effects of the neurotoxin lead, known to affect cognitive and behavioral development in children. We showed that, as in vertebrates, lead affects both synaptic development and complex behaviors (courtship, fecundity, locomotor activity) in Drosophila. By assessing differential behavioral responses to developmental lead exposure among recombinant inbred Drosophila lines (RI), derived from parental lines Oregon R… Show more

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Cited by 30 publications
(30 citation statements)
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“…These lines vary in the presence or absence of site-specific DNA markers at approximately 80 sites throughout the genome. Flies were reared as described in Hirsch et al (2009) in either control or leaded medium (250 μM PbAc). Flies were tested for Pb load at six d post-eclosion.…”
Section: Methodsmentioning
confidence: 99%
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“…These lines vary in the presence or absence of site-specific DNA markers at approximately 80 sites throughout the genome. Flies were reared as described in Hirsch et al (2009) in either control or leaded medium (250 μM PbAc). Flies were tested for Pb load at six d post-eclosion.…”
Section: Methodsmentioning
confidence: 99%
“…Several measurable endpoints have been suggested by others for the use of Drosophila as a toxicology model (Rand, 2010; Rand et al, 2014); these include, but are not limited to, lethality, morphology, behavioral traits, embryonic development, and targeted mechanistic studies. We have established D. melanogaster as a model system to investigate the behavioral, physiological, and genetic effects of chronic, developmental Pb exposure (He et al, 2009; Hirsch et al, 2003; Hirsch et al, 2009; Morley et al, 2003; Ruden et al, 2009). …”
Section: Introductionmentioning
confidence: 99%
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“…30AB contains about 125 genes among which are likely “candidate genes” for the observed lead-dependent behavioral changes. To the best of our knowledge, this is the first identification of a portion of the D. melanogaster genome that is involved in a behavioral response to lead (Hirsch et al, 2009). Using D. melanogaster , we have identified a “critical period” (the first 4 days of adult life) during which lead affects adult behaviors.…”
Section: Introductionmentioning
confidence: 95%
“…The 'actimeter' system for automated recording of larval foraging activity This system was designed by Chardonnet et al (Chardonnet et al, 2012) from a device initially developed for the fruit fly, the DAM system (Drosophila Activity Monitoring System, DAM2 ® ; Trikinetics, Waltham, MA, USA) (Freeman et al, 2010;Hirsch et al, 2009;Huang et al, 2009). The actimeter apparatus is made of tubular units (200×7 mm i.d.…”
Section: Activation Of Pkamentioning
confidence: 99%