Variations dans les taux de lipides plasmatiques en fonction de l'infection àPlasmodium Falciparumà São Tomé

Abstract

Changes in lipid plasma levels during malaria attacks have been proposed for use in diagnosis or to assess the severity of the disease. In order to analyse the plasma levels of cholesterol, triglycerides, HDL-C et LDL-C, we compared, in an endemic area (Sao Tome island), two groups of patients children infected with Plasmodium falciparum (simple malaria attack and cerebral malaria) with a control group of asymptomatic children. No correlation between lipid plasma levels and disease severity was found. Cortelations between lipids and parasitemia or anemia were analysed. The mechanism of plasma lipid changes during attack ate discussed.KEYWORDS : malaria, Plasmodium falciparum, cholesterol, triglycerides, HDL, LDL, anemia. Résumé : Les variations des niveaux des lipides plasmatiques pendant l'accès ont suggéré l'utilisation de leur dosage comme test diagnostique ou comme indicateur de la sévérité de la maladie. Dans le but d'évaluer le changement des cholestérol total (CT), triglycérides (TG), HDL-cholestérol (HDL-C) et LDL-cholestérol pendant l'accès palustre en région endémique (île de São Tomé), on a sélectionné deux groupes d'enfants infectés par

Metabolic Signature Profiling as a Diagnostic and Prognostic Tool in Pediatric Plasmodium falciparum Malaria

“…Triglycerides were shown to be elevated during malaria infection compared with healthy controls but not statistically significant compared with symptomatic controls. Although the quantity of lipid changes seems to be related to the severity of malaria in some studies [19, 45], others found no correlation [46, 47]. In our study, we identified a positive correlation of lipid-related molecules to parasitemia, reinforcing the finding.…”

Serum lipids and lipoproteins in malaria - a systematic review and meta-analysis

“…Subsequently, several clinical studies showed lipid profile changes in the setting of both uncomplicated and complicated malaria [5-10]. Although the magnitude of changes seems to be related to the severity of malaria in several studies [11,12], others found no correlation between the severity of malaria attacks and the extent of lipid profile changes [13,14]. These transient lipid profile changes in the parasitaemic phase have been suggested by some researchers as a potential adjuvant diagnostic tool for malaria [13,15,16].…”

Severe Malaria: Metabolic Complications

“…However there is no relationship between cholesterol and disease severity [134]. In Gabonese children hypertriglyceridaemia is also seen in acute malaria, but as with cholesterol levels there is no relationship with disease severity [134] and triglyceride levels return to normal within a fortnight of treatment. A study of Indian adults also showed that triglycerides were elevated during acute infection.…”

“…Hypocholesterolaemia has been noted in adults and children with malaria in Gabon [129][130][131][132][133][134]. HDL-cholesterol is low and LDL-cholesterol remains normal [131].…”

“…HDL-cholesterol is low and LDL-cholesterol remains normal [131]. However there is no relationship between cholesterol and disease severity [134]. In Gabonese children hypertriglyceridaemia is also seen in acute malaria, but as with cholesterol levels there is no relationship with disease severity [134] and triglyceride levels return to normal within a fortnight of treatment.…”