Variations in 5-HTTLPR: Relation to familiar risk of affective disorder, life events, neuroticism and cortisol

Vinberg, Maj; Mellerup, Erling T.; Andersen, Per Kragh; Bennike, Bente; Kessing, Lars Vedel

doi:10.1016/j.pnpbp.2009.10.002

Cited by 17 publications

(12 citation statements)

References 42 publications

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“…Replication with a larger sample would be highly desirable. That said, empirical support for the reported GXE findings emerged recently in a study (N = 206) by Vinberg, Mellerup, Andersen, Bennike, and Kessing (50) in which 5-HTTLPR interacted with recent life events in the prediction of neuroticism: Individuals with short alleles had higher neuroticism scores in response to stressful life events compared to those homozygous for the long allele; and, (7) finally, an outcome measure of human functioning along a continuum ranging from dysfunction to competence and not just from dysfunction to its absence—as in the current study—may have yielded even more substantial evidence of differential susceptibility.…”

Section: Discussionmentioning

confidence: 66%

5-HTTLPR moderates effects of current life events on neuroticism: Differential susceptibility to environmental influences

Pluess

Belsky

Way

et al. 2010

Progress in Neuro-Psychopharmacology and Biological Psychiatry

104

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Research chronicling links between a polymorphism in the serotonin transporter gene (5-HTTLPR) and neuroticism has yielded inconsistent results. One possible explanation for this inconsistency is that any gene-phenotype association is obscured by a gene-X-environment (GXE) interaction. We studied a healthy non-clinical sample (N = 118) to determine whether the 5-HTTLPR interacts with current life events in predicting neuroticism. The differentialsusceptibility hypothesis led to the prediction of such an interaction, reflecting the fact that individuals with short alleles would be affected more by both negative and positive life events than those homozygous for long alleles. Participants completed questionnaires concerning recent life events and neuroticism. The 5-HTTLPR was genotyped using a standard protocol with DNA extracted from oral fluid. For those homozygous for the short allele, more negative life events proved related to greater neuroticism, whereas more positive life events proved related to less neuroticism. No such association emerged in the case of those homozygous for the long allele. Whereas neuroticism is likely to be an especially stable trait in individuals homozygous for the long allele, this may be less so the case for those carrying short alleles.

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Section: Discussionmentioning

confidence: 66%

5-HTTLPR moderates effects of current life events on neuroticism: Differential susceptibility to environmental influences

Pluess

Belsky

Way

et al. 2010

Progress in Neuro-Psychopharmacology and Biological Psychiatry

104

View full text Add to dashboard Cite

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“…Finally, two recent studies reported that the combination of the 5-HTTLPR S allele and negative life events (NLE) increased N scores in healthy individuals (Pluess et al, 2010;Vinberg et al, 2010). However, no interaction between 5-HTTLPR and NLE in N modulation emerged (Antypa and Van Der Does, 2010;Stein et al, 2008;Middeldorp et al, 2010).…”

Section: Serotonin Transporter (Slc6a4)mentioning

confidence: 98%

Genetic modulation of personality traits

Balestri

Calati

Serretti

et al. 2014

International Clinical Psychopharmacology

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The heritability of human personality traits is by now well established. However, since the first reports on associations between specific genetic variants and personality traits, only modest progress has been made in identifying loci that robustly support these associations. The aim of this study was to provide a summary of literature data on association studies focused on the genetic modulation of personality, according to the Cloninger, Eysenck and Costa and McCrae models. PubMed was searched for papers investigating the association between any gene variant and personality traits, which were grouped into five clusters: (a) anxiety, (b) impulsivity, (c) determination-activity, (d) socialization and (e) spirituality, in healthy individuals, populations and psychiatric patients. A total of 369 studies were included. No clear consensus on the role of any individual gene variant in personality modulation emerged, although SLC6A4 haplotypes and the DRD4 rs1800955 promoter variant seemed to be more reliably related to anxiety and impulsivity-related traits, respectively. Because conflicting results emerged from the literature, plausibly as a result of the combined influence of many loci of small effects on personality, larger sample sizes and more narrow and specific phenotype will be the minimum requirements for future genetic studies on personality. Moreover, gene × gene and gene × environment interaction studies deserve further attention.

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“…To overcome this issue it would have been necessary to use register linkage, as performed previously in larger population-based studies. 69 Moreover, we did not study participants' strategies for coping with early-life adversity or their resilience behaviourally (e.g., with respect to current stressors), so we were not able to investigate the association between increased fractional anisotropy and coping mechanisms. White matter fibre crossing is always an issue in DTI studies, TBSS are limited to investigating local changes in white matter integrity, and interpreting differences in regions of crossing fibres can be complex.…”

Section: J Psychiatry Neurosci 2012;37(1)mentioning

confidence: 99%

Effects of early-life adversity on white matter diffusivity changes in patients at risk for major depression

Frodl

Carballedo

Fagan

et al. 2012

jpn

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Variations in 5-HTTLPR: Relation to familiar risk of affective disorder, life events, neuroticism and cortisol

Cited by 17 publications

References 42 publications

5-HTTLPR moderates effects of current life events on neuroticism: Differential susceptibility to environmental influences

5-HTTLPR moderates effects of current life events on neuroticism: Differential susceptibility to environmental influences

Genetic modulation of personality traits

Effects of early-life adversity on white matter diffusivity changes in patients at risk for major depression

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