Variations in behavioral inhibition following different septal lesions in rats.

Hamilton, Leonard W.; Kelsey, John E.; Grossman, Sebastian P.

doi:10.1037/h0028387

Cited by 96 publications

(48 citation statements)

References 11 publications

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“…Our findings confirm previous reports that the locus of the disinhibitory effect of septal lesions on behavior suppression by the threat of shock lies in the lateral septal region (Hamilton et al, 1970;McGowan et aI., 1972). Both the LS group and the FM group, in which the medial septal area and the theta rhythm were essentially intact, showed disinhibition of responding in the shock periods in Phase 1.…”

Section: Discussionsupporting

confidence: 93%

“…The latter finding confirmed other suggestions that the increased resistance to extinction which results from large lesions in the septal area is due specifically to medial septal damage (Donovick, 1968;Grossman, 1976). However, both in the present experiment and in those of Hamilton et al (1970) and McGowan et al (1972) it was damage to the lateral, not the medial, septal area which alleviated the response suppression caused by punishment.…”

Section: Discussionsupporting

confidence: 91%

“….35 rnA), this difference did not quite attain acceptable levels of significance. Thus, our results indicate that damage to the medial septal area has, at best, only a slight effect on the suppression of responding by shock, again in agreement with Hamilton et al (1970) and McGowan et al (1972).…”

Section: Discussionsupporting

confidence: 86%

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Effects of lateral and medial septal lesions on response suppression maintained by response-contingent and response-independent shock

1982

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Rats with electrolytic lesions in the medial (MS) or lateral (LS) septal areas were allocated to groups on electrophysiological criteria (loss or persistence of hippocampal theta rhythm, respectively) subject to subsequent histological checking. They were trained to press a lever for sucrose reward on a random interval (RI) schedule and while leverpressing were presented with two stimuli, each associated with a different schedule of shock delivery: in the presence of one, shocks occurred on an RI schedule irrespective of the rat's behavior; in the presence of the other, shocks were programmed by the same schedule but delivered only when the rat pressed the lever. Both stimuli suppressed leverpressing. MS, but not LS, lesions significantly increased baseline RI responding; LS, but not MS, lesions significantly disinhibited responding suppressed by signaled shock, whether or not the shock was response-contingent. These changes were related to the effects of MS and LS lesions on hippocampal theta.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

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Effects of lateral and medial septal lesions on response suppression maintained by response-contingent and response-independent shock

1982

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“…These data are, thus, consistent with the findings that the septal area is complex and consists of several distinct neural systems, some with apparently opposing functions (e.g., Hamilton, Kelsey, & Grossman, 1970;Kelsey & Baker, 1983;Swanson & Cowan, 1979). In particular, these data are consistent with the hypothesis that damage to fibers in the ventromedial septum reduce several responses to the stress of inescapable shocks (Kelsey & Baker, 1983), including gastric erosion formation.…”

Section: Discussionsupporting

confidence: 88%

Ventromedial septal lesions in rats reduce stomach erosions produced by inescapable shock

Kelsey

1983

Psychobiology

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Exposure to inescapable shock produced fewer and less extensive stomach erosions in rats with ventromedial septal lesions than in the sham·operated controls. This finding, in conjunc· tion with our previous findings that ventromedial septal lesions also reduce several other physiological and behavioral responses to the stress of inescapable shock, indicates that this area of the limbic system is importantly involved in mediating several responses to inescapable shock. It is suggested that, by disrupting the cholinergic septohippocampal system, ventromedial septal lesions may reduce the ability of rats to learn that shocks are inescapable or may reduce the aversiveness of such knowledge.Lesions of the ventromedial septum in rats reduce or eliminate several physiological and behavioral responses to the stress of inescapable shock. For example, these lesions reduce the enhanced secretion of corticosterone (Kelsey, 1975), the loss of body weight, and the analgesia or decreased pain sensitivity produced by exposure to inescapable shocks (Kelsey & Baker, 1983). In addition to reducing these shortterm responses to inescapable shocks, ventromedial septal lesions also reduce the interfering effects of inescapable shocks on subsequent escape performance (learned helplessness; Kelsey & Baker, 1983).The intent of this study was to explore the generality of these findings by determining if ventromedial septal lesions would also reduce another physiological response to inescapable shock-stomach erosions, commonly referred to as stress ulcers. Indicating that these lesions might reduce gastric erosion formation, Brick, Burright, and Donovick (1979) reported that large septal lesions reduced the length of gastric erosions produced by 3 h of cold restraint. However, Henke (1982) found that large septal lesions did not affect the formation of gastric erosions produced by 24 h of restraint at room temperature. METHOD SubjectsThe 33 naive, male Sprague·Dawley rats weighed 221-300 g at the time of surgery. They were housed one to a cage in a colony that was lighted from 7 a.m. to 7 p.m. each day. They had adlib access to food and water except where noted. SaraerYThe rats were injected ip with .5 ce of atropine sulfate (I mg/cc) Reprint requests should be sent to the author at the Department of Psychology, Bates College, Lewiston, ME 04240. 10 min prior to the ip injection of the anesthetic, Equi-Thesin (Jensen-Salsbery; 2.8 ce/kg). Electrolytic lesions were made in the ventromedial septum of 19 rats by passing 2 rnA of anodal current for 15 sec between the stereotaxically positioned brain electrode and an indifferent electrode attached to the skin opened by the incision. The brain electrode, which was implanted at an II· deg angle to avoid the midsagittal sinus, was a stainless steel No. I insect pin, completely insulated except for the cross section of the flattened tip. Sham operations that were identical except that the electrode was not lowered into the brain were performed on 14 rats. ApparatusTwo 20 x 49 X 31 cm shuttleboxes we...

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“…Hamilton, Kelsey, and Grossman (1970) found that lesions located anywhere in the SNC facilitated the acquisition of an AAR, while lesions restricted to the lateral septal nuclei impaired passive avoidance acquisition, but did not Interfere with a position-reversal task in a T-maze. Lesions involving both the medial septal nucleus and the lateral septal nuclei produced perseverative behavior in the same position-reversal task.…”

Section: Appetitive Behavior and Drive Levelmentioning

confidence: 99%

Behavioral perseveration: lesions of the septal nuclear complex and ventromedial hypothalamic nucleus

LaVaque

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Variations in behavioral inhibition following different septal lesions in rats.

Cited by 96 publications

References 11 publications

Effects of lateral and medial septal lesions on response suppression maintained by response-contingent and response-independent shock

Effects of lateral and medial septal lesions on response suppression maintained by response-contingent and response-independent shock

Ventromedial septal lesions in rats reduce stomach erosions produced by inescapable shock

Behavioral perseveration: lesions of the septal nuclear complex and ventromedial hypothalamic nucleus

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