Variations in Cardiac Diastolic Function in Hypertensive Patients with Different Left Ventricular Geometric Patterns.

Qü, Ping; Ding, Yanchun; Dao-zi, Xia; Wang, Hongyan; Tian, Xiaofeng

doi:10.1291/hypres.24.601

Cited by 15 publications

(5 citation statements)

References 11 publications

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“…Previous studies on hypertensive patients have also reported an association between arterial stiffness and LV structural changes,18) including concentric remodelling and hypertrophy,19) which are themselves associated with diastolic dysfunction 20)21). However, in this study, even in subjects with hypertension with normal LV mass, carotid stiffness was increased with diastolic dysfunction.…”

Section: Discussioncontrasting

confidence: 68%

The Correlation of Carotid Artery Stiffness with Heart Function in Hypertensive Patients

Myung

Seo

Jung

et al. 2012

J Cardiovasc Ultrasound

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BackgroundThe strength of each heart beat and the stiffness of large arteries contribute to blood pressure (BP). When the large arteries are stiff and their resistance greater, the afterload increases and this may change the function of the heart. However, the relation between common carotid artery stiffness and heart function in hypertensive patients has not been clarified.MethodsTwo hundred and twenty hypertensive patients underwent transthoracic and carotid echocardiography. Measurements of local arterial stiffness were taken at the right common carotid artery level and stiffness parameter (β), pressure-strain elasticity modulus and intima-media thickness were calculated. Brachial cuff BP was measured just before starting the carotid study. The patients with any cardiovascular disease, diabetes mellitus, stroke, transient ischemic attack, or carotid stenosis were excluded.ResultsCarotid artery stiffness parameter (β) was correlated with age and left ventricular mass index (p < 0.005). Even though β was not correlated with LV systolic function, it was inversely correlated with diastolic function as measured by early mitral annular velocity. When the artery was stiffer, early mitral annular velocity (e') decreased (p < 0.001) and the index of left atrial (LA) pressure (early diastolic mitral inflow E velocity/e') increased (p = 0.001). In logistic regression, diastolic dysfunction was affected by age (beta -0.385, p = 0.001), LA volume index (beta 0.175, p = 0.013) and β (beta -0.273, p = 0.019).ConclusionIn hypertensive patients, changes in carotid artery stiffness can affect the diastolic function, independent of age and LA volume index. Therefore, measurements and control of carotid stiffness can play an important role in the prevention of diastolic heart failure.

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Section: Discussioncontrasting

confidence: 68%

The Correlation of Carotid Artery Stiffness with Heart Function in Hypertensive Patients

Myung

Seo

Jung

et al. 2012

J Cardiovasc Ultrasound

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“…The echocardiographic determination of atrial and LV dimensions in hypertensive patients clearly indicated that this group of patients had concentric LV hypertrophy, as the patients reported by Qu and collaborators [ 39 ], and that it was associated with the highest degree of diastolic dysfunction.…”

Section: Discussionsupporting

confidence: 53%

Oxidative Stress State Is Associated with Left Ventricular Mechanics Changes, Measured by Speckle Tracking in Essential Hypertensive Patients

Moreno-Ruíz

Ibarra-Quevedo

Rodrı́guez-Martı́nez

et al. 2015

Oxidative Medicine and Cellular Longevity

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The oxidative stress state is characterized by an increase in oxygen reactive species that overwhelms the antioxidant defense; we do not know if these pathological changes are correlated with alterations in left ventricular mechanics. The aim was correlating the oxidative stress state with the left ventricular global longitudinal strain (GLS) and the left ventricular end diastolic pressure (LVEDP). Twenty-five patients with essential hypertension and 25 controls paired by age and gender were studied. All of the participants were subjected to echocardiography and biochemical determination of oxidative stress markers. The hypertensive patients, compared with control subjects, had significantly (p < 0.05) higher levels of oxidized proteins (5.03 ± 1.05 versus 4.06 ± 0.63 nmol/mg), lower levels of extracellular superoxide dismutase (EC-SOD) activity (0.045 ± 0.02 versus 0.082 ± 0.02 U/mg), higher LVEDP (16.2 ± 4.5 versus 11.3 ± 1.6 mm Hg), and lower GLS (−12% versus −16%). Both groups had preserved ejection fraction and the results showed a positive correlation of oxidized proteins with GLS (r = 0.386, p = 0.006) and LVEDP (r = 0.389, p = 0.005); we also found a negative correlation of EC-SOD activity with GLS (r = −0.404, p = 0.004) and LVEDP (r = −0.347, p = 0.014).

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“…Other studies have also demonstrated that hypertensive patients may have diastolic dysfunction, regardless of the differences in their structural geometries. 12 , 25 , 38 – 40 In addition, the degree of impairment of cardiac diastolic function differed between hypertensive patients with different LV geometric patterns, 12 , 39 , 40 which was worst in those with concentric geometry. 12 Diastolic dysfunction was observed in incipient stages of hypertensive heart disease, and thus its early detection may help in the risk stratification of hypertensive patients.…”

Section: Discussionmentioning

confidence: 99%

Echocardiographic Assessment of Left Ventricular Geometric Patterns in Hypertensive Patients in Nigeria

Adebayo

Bamikole

Balogun

et al. 2013

Clin Med Insights Cardiol

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Left ventricular (LV) hypertrophy is an important predictor of morbidity and mortality in hypertensive patients, and its geometric pattern is a useful determinant of severity and prognosis of heart disease. Studies on LV geometric pattern involving large number of Nigerian hypertensive patients are limited. We examined the LV geometric pattern in hypertensive patients seen in our echocardiographic laboratory. A two-dimensional, pulsed, continuous and color flow Doppler echocardiographic evaluation of 1020 consecutive hypertensive patients aged between 18 and 91 years was conducted over an 8-year period. LV geometric patterns were determined using the relationship between the relative wall thickness and LV mass index. Four patterns of LV geometry were found: 237 (23.2%) patients had concentric hypertrophy, 109 (10.7%) had eccentric hypertrophy, 488 (47.8%) had concentric remodeling, and 186 (18.2%) had normal geometry. Patients with concentric hypertrophy were significantly older in age, and had significantly higher systolic blood pressure (BP), diastolic BP, and pulse pressure than those with normal geometry. Systolic function index in patients with eccentric hypertrophy was significantly lower than in other geometric patterns. Doppler echocardiographic parameters showed some diastolic dysfunction in hypertensive patients with abnormal LV geometry. Concentric remodeling was the most common LV geometric pattern observed in our hypertensive patients, followed by concentric hypertrophy and eccentric hypertrophy. Patients with concentric hypertrophy were older than those with other geometric patterns. LV systolic function was significantly lower in patients with eccentric hypertrophy and some degree of diastolic dysfunction were present in patients with abnormal LV geometry.

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Variations in Cardiac Diastolic Function in Hypertensive Patients with Different Left Ventricular Geometric Patterns.

Cited by 15 publications

References 11 publications

The Correlation of Carotid Artery Stiffness with Heart Function in Hypertensive Patients

The Correlation of Carotid Artery Stiffness with Heart Function in Hypertensive Patients

Oxidative Stress State Is Associated with Left Ventricular Mechanics Changes, Measured by Speckle Tracking in Essential Hypertensive Patients

Echocardiographic Assessment of Left Ventricular Geometric Patterns in Hypertensive Patients in Nigeria

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