Variations in Definitions and Outcome Measures in Gastroesophageal Reflux Disease: A Systematic Review

Singendonk, Maartje; Brink, Anna J; Steutel, Nina F; Etten-Jamaludin, Faridi S. van; Wijk, Michiel P. van; Benninga, Marc A.; Tabbers, Merit M.

doi:10.1542/peds.2016-4166

Cited by 20 publications

(20 citation statements)

References 74 publications

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“…Reflux and GORD are difficult to differentiate, with both terms used interchangeably by healthcare professionals and families24 and with varying definitions. Among US paediatric hospitals, rates of GORD diagnosis varied threefold,25 and in a systematic review of interventions for these conditions, 26 studies of reflux defined reflux in 25 different ways, and all 21 studies of GORD used a unique definition 26. In our study, most GPs managed only one visit for either of these conditions; therefore, we could not examine consistency in diagnoses or labelling and associated management.…”

Section: Discussionmentioning

confidence: 87%

Acid suppressants for managing gastro-oesophageal reflux and gastro-oesophageal reflux disease in infants: a national survey

et al. 2018

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Overprescribing of acid suppressants to infants may be occurring. In infants, acid-suppressant medicines are no better than placebo and may have significant negative side effects; however, guidelines are inconsistent. Clear, concise and consistent guidance is needed. GPs and parents need to understand what is normal and limitations of medical therapy. We need a greater understanding of the influences on GP prescribing practices, of parents' knowledge and attitudes and of the pressures on parents of infants with these conditions.

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Section: Discussionmentioning

confidence: 87%

Acid suppressants for managing gastro-oesophageal reflux and gastro-oesophageal reflux disease in infants: a national survey

et al. 2018

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“…Benedictis & Bush, 2017; Kleinman et al, 2006;Sherman et al, 2009;Singendonk, Brink, et al, 2017;Singendok, Tabbers, Benninga, & Langendam, 2017;Tolia, Wuerth, & Thomas, 2003;Vandenplas & Hauser, 2015).…”

Section: Enfermedad Del Refl Ujo Gastroesofágico: Evaluación Psicol óunclassified

Gastroesophageal Reﬂ ux Disease: Psychological Assessment of Children and Caregivers

2019

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Gastroesophageal Refl ux Disease (GERD) with high prevalence and incidence in the pediatric population is a relevant issue in public health. The literature associates family psychosocial aspects with chronic childhood illness. The present study examined the psychological alterations and peculiarities of caregivers and of children with GERD (n = 26) and healthy children (n = 30) from 3 to 12 years of age. Instruments: Sociodemographic Questionnaire and Assessment of Risk Factors for Child Illness; Hospital Anxiety and Depression Scale; and Rutter's Child Behavior Scale (A2), all of which were administered to the caregivers. Quantitative data analysis (χ2 test, Fisher's exact test and ANOVA) was performed, respecting each instrument's respective criteria. In the group of children with GERD, we observed both a higher incidence of alcohol and/or drug use/abuse and higher levels of anxiety and depression on the part of the caregivers, as well as psychosocial problems involving the child. In light of the developmental level expected for this age group, greater frequency of behavioral problems was also observed. We thus conclude that there is a correlation between family psychological traits and GERD in children, stressing the need for conducting further studies and for supervising interdisciplinary clinical practices in the health care of this population.

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“…The Pediatric Gastroesophageal Reflux Clinical Practice Guidelines from 2018 list BRUEs as one of the 23 signs and symptoms of GORD but do not make a comment about the likely prevalence of this presenting symptom [10]. One of the biggest difficulties about examining the effect of GOR on BRUEs is that there is a huge variation in definitions, investigative tools, outcome measures and prevalence reports used in the literature on GOR [11, 12]. For example, pH studies, regarded by many as the standard diagnostic tool for GOR, only measures acid reflux (pH <4).…”

Section: Introductionmentioning

confidence: 99%

Gastro-oesophageal reflux is not a major cause of brief resolved unexplained events in infants

Jilani

Hussain

Ansari

et al. 2019

Breathe

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The clinical scenario of an infant presenting to the emergency department with the parents reporting a history of the child stopping breathing, choking or “turning blue” at home is a well-recognised event and accounts for between 2.5 and 4.1 hospital admissions per 1000 live births [1, 2]. The infant is often back to their normal self with a normal clinical examination. This event used to be called an apparent life-threatening event (ALTE) [1] and recently it has been suggested that it should now be called a brief resolved unexplained event (BRUE) [2]. Gastro-oesophageal reflux (GOR) has long been considered to be a common reason for an ALTE and some studies have listed it as an underlying cause in up to 54% of patients [3–6]. Does the evidence support this belief?

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Variations in Definitions and Outcome Measures in Gastroesophageal Reflux Disease: A Systematic Review

Abstract: Inconsistency and heterogeneity exist in definitions and outcome measures used in RCTs on pediatric GER and GERD; therefore, we recommend the development of a core outcome set.

Cited by 20 publications

References 74 publications

Acid suppressants for managing gastro-oesophageal reflux and gastro-oesophageal reflux disease in infants: a national survey

Acid suppressants for managing gastro-oesophageal reflux and gastro-oesophageal reflux disease in infants: a national survey

Gastroesophageal Reﬂ ux Disease: Psychological Assessment of Children and Caregivers

Gastro-oesophageal reflux is not a major cause of brief resolved unexplained events in infants

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