Variations in erythrocyte antioxidant glutathione peroxidase activity during the menstrual cycle

Massafra, C; Felice, Claudio De; Gioia, Dino; Buonocore, Giuseppe

doi:10.1046/j.1365-2265.1998.00441.x

Cited by 37 publications

(29 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The 3-month exposure time was considered long enough because comparable clinical studies with hormone therapy demonstrate significant changes in serum lipids and antioxidative enzyme activity [18,19] or even during the menstrual cycle [20].…”

Section: Conflict Of Interestmentioning

confidence: 99%

Effect of hormone replacement therapy on total serum anti-oxidant potential and oxidized LDL/.BETA.2-glycoprotein I complexes in postmenopausal women

et al. 2010

View full text Add to dashboard Cite

Section: Conflict Of Interestmentioning

confidence: 99%

Effect of hormone replacement therapy on total serum anti-oxidant potential and oxidized LDL/.BETA.2-glycoprotein I complexes in postmenopausal women

et al. 2010

View full text Add to dashboard Cite

“…The presence of this phenol group gives estrogen its antioxidant property by scavenging oxygen free radicals. Furthermore, estrogens can induce antioxidant enzyme expression by stimulating the antioxidant defense system (14).…”

Section: Introductionmentioning

confidence: 99%

Myocardial antioxidant and oxidative stress changes due to sex hormones

Barp

Araújo

Fernandes

et al. 2002

Braz J Med Biol Res

154

116

View full text Add to dashboard Cite

The purpose of the present study was to examine myocardial antioxidant and oxidative stress changes in male and female rats in the presence of physiological sex hormone concentrations and after castration. Twenty-four 9-week-old Wistar rats were divided into four groups of 6 animals each: 1) sham-operated females, 2) castrated females, 3) sham-operated males, and 4) castrated males. When testosterone and estrogen levels were measured by radioimmunoassay, significant differences were observed between the castrated and control groups (both males and females), demonstrating the success of castration. Progesterone and catalase levels did not change in any group. Control male rats had higher levels of glutathione peroxidase (50%) and lower levels of superoxide dismutase (SOD, 14%) than females. Control females presented increased levels of SOD as compared to the other groups. After castration, SOD activity decreased by 29% in the female group and by 14% in the male group as compared to their respective controls. Lipid peroxidation (LPO) was assessed to evaluate oxidative damage to cardiac membranes by two different methods, i.e., TBARS and chemiluminescence. LPO was higher in male controls compared to female controls when evaluated by both methods, TBARS (360%) and chemiluminescence (46%). Castration induced a 200% increase in myocardial damage in females as determined by TBARS and a 20% increase as determined by chemiluminescence. In males, castration did not change LPO levels. These data suggest that estrogen may have an antioxidant role in heart muscle, while testosterone does not.

show abstract

“…In addition, the increased activities of GPx and CAT in erythrocytes were observed during extended use of oral contraceptives (Massafra et al 1993(Massafra et al , 1996. Healthy women with a normal ovulatory cycle manifested changes in the activity of GPx depending on the phase of the cycle, so the activity of this enzyme was higher in the late stage of the F phase in comparison to the earlier L phase (Massafra et al 1998(Massafra et al , 2000. There was a positive correlation between serum estradiol and changes in GPx activity relative to the phase of the menstrual cycle (Massafra et al 2000, Bednarek-Tupikowska et al 2001.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant status in women with uterine leiomyoma: relation with sex hormones

Pejić

Todorović

Stojiljković

et al. 2015

An. Acad. Bras. Ciênc.

View full text Add to dashboard Cite

Uterine leiomyomas are benign soft-tissues tumors that arise from uterine smooth muscle tissue. Etiopathogenesis of leiomyomas is not well understood. We aimed to examine whether antioxidant enzyme activities and lipid hydroperoxides level in patients with leiomyoma are influenced by changes in sex hormones and gonadotropins (estradiol (E2), progesterone, FSH, and LH) during menstrual cycle and in postmenopause. The material consisted of blood and uterine tissue specimens. Hormone concentrations were determined and assays for superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase activities and lipid hydroperoxides concentration were performed. In blood of examined women, a significant difference in catalase, glutathione peroxidase and glutathione reductase activity was recorded among the phases. There was also a positive correlation between the estradiol/progesterone concentration and the catalase activity. Progesterone negatively correlated with lipid hydroperoxides level. In myoma tissue, we recorded a phase-related difference in lipid hydroperoxides level and activities of superoxide dismutase, glutathione peroxidase activities, and glutathione reductase. Negative correlation was observed between FSH and glutathione peroxidase. The results suggest that antioxidant status in patients with uterine leiomyoma is influenced by the changes in sex hormones during the menstrual cycle and in postmenopause, indicating a role of the observed relationship in the leiomyoma etiology.

show abstract

Variations in erythrocyte antioxidant glutathione peroxidase activity during the menstrual cycle

Abstract: The findings support the hypothesis that physiological ovarian E2 production during the menstrual cycle may play an important role in regulating erythrocyte glutathione peroxidase activity.

Cited by 37 publications

References 20 publications

Effect of hormone replacement therapy on total serum anti-oxidant potential and oxidized LDL/.BETA.2-glycoprotein I complexes in postmenopausal women

Effect of hormone replacement therapy on total serum anti-oxidant potential and oxidized LDL/.BETA.2-glycoprotein I complexes in postmenopausal women

Myocardial antioxidant and oxidative stress changes due to sex hormones

Antioxidant status in women with uterine leiomyoma: relation with sex hormones

Contact Info

Product

Resources

About