1996
DOI: 10.1046/j.1365-2249.1996.36742.x
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Variations in immunoglobulins and IgA subclasses of human uterine cervical secretions around the time of ovulation

Abstract: SUMMARYThe quantity and subclass distribution of IgA produced by the human uterine cervix may have a significant impact on the defence against sexually transmitted diseases as well as the regulation of fertility. Cervical mucus was obtained from 15 normal ovulating women around the time of ovulation. The total amounts of secreted IgA (including IgA1 and IgA2), IgG, and IgM were determined by ELISA. IgA was detected at high levels in all samples of cervical mucus. When ovulation was ascertained by daily urinary… Show more

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Cited by 144 publications
(109 citation statements)
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“…These results indicate that use of CpG ODN as a mucosal adjuvant may induce sufficient levels of specific IgA in the genital tract to protect from infection throughout the murine reproductive cycle. Because similar fluctuations in Ab levels have been associated with the menstrual cycle (37)(38)(39), these results may also extend to primates and humans.…”
Section: Discussionsupporting
confidence: 53%
“…These results indicate that use of CpG ODN as a mucosal adjuvant may induce sufficient levels of specific IgA in the genital tract to protect from infection throughout the murine reproductive cycle. Because similar fluctuations in Ab levels have been associated with the menstrual cycle (37)(38)(39), these results may also extend to primates and humans.…”
Section: Discussionsupporting
confidence: 53%
“…The presence of IgA in the vaginal secretions is expected because of the overlap among tissue sites in the common mucosal immune system (26,70,71). Although IgA in the vaginal secretions was likely to be locally produced, the IgG was likely to be from the circulation because as much as 50% of the IgG in cervicovaginal secretions originates from systemic sources (72).…”
Section: Discussionmentioning
confidence: 99%
“…Urine and genital tract secretions contain equal or higher levels of IgG than IgA. Furthermore, in female genital tract secretions, IgA is represented by SIgA, pIgA, and monomeric IgA (mIgA), with a slight excess of IgA2 (7,8). These marked differences in Ig isotype distribution in female genital tract secretions are partly due to the pronounced influence of sex hormones on the regulation of the distribution and selectivity of Ig transport during the menstrual cycle (9).…”
mentioning
confidence: 99%