Variations in native protein glycation and plasma antioxidants in several birds of prey

Ingram, Tana Dawn; Zuck, Jessica; Borges, Chad R.; Redig, Patrick T.; Sweazea, Karen L.

doi:10.1016/j.cbpb.2017.05.004

Cited by 7 publications

(2 citation statements)

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“…We should therefore tale into account other important antioxidants such as vitamin E, vitamin A and carotenoids, which may be less abundant in the diets of terrestrial carnivores (e.g. [90], but see [49]). The question of whether the diet of aquatic carnivores provides a better intake of antioxidants would therefore requires a more detailed description of dietary habits.…”

Section: Terrestrial Carnivores Show a Paradoxically Increased Albumi...mentioning

confidence: 99%

“…To date, several studies have measured protein glycation levels in birds, but these have included a reduced number of species and are merely descriptive [43][44][45][46][47][48][49][50][51]. Additionally, many of these studies employ commercial kits that were not specifically designed for avian species, making it challenging to interpret the results [50].…”

Section: Introductionmentioning

confidence: 99%

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Variation in albumin glycation rates in birds suggests resistance to relative hyperglycaemia rather than conformity to the pace of life syndrome hypothesis

Moreno-Borrallo,

Jaramillo-Ortiz,

Schaeffer-Reiss

et al. 2024

Preprint

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The pace of life hypothesis (POL) suggests that organisms’ life history, physiological and behavioural traits should co-evolve. In this context, glycaemia (i.e., blood glucose levels) and its consequences to ageing through its reaction with proteins and other compounds (i.e. glycation) constitute physiological traits which remain under-investigated in an evolutionary comparative framework, notably in relation to life history traits and ecological factors. Although their blood glucose levels are twice as high as in mammals, birds live longer when accounting for their body mass. We thus performed a comparative analysis on glucose and albumin glycation rates on 87 bird species from 22 orders, in relation to life history traits (body mass, clutch mass, maximum lifespan and developmental time) and diet. Glucose levels correlated positively with albumin glycation rates in a non-linear fashion, suggesting resistance to glycation in species with higher glucose levels. Plasma glucose levels decreased with increasing body mass and increased with maximum lifespan before reaching a plateau. Finally, terrestrial carnivores showed higher albumin glycation compared to omnivores. Our results open an important new avenue of research to help us to better understand the striking condition of hyperglycaemic yet long-lived birds.

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Section: Terrestrial Carnivores Show a Paradoxically Increased Albumi...mentioning

confidence: 99%