Variations in normal coronary vasodilatory reserve stratified by artery, gender, heart transplantation and coronary artery disease

Kern, Morton J.; Bach, Richard G.; Mechem, Carol; Caracciolo, Eugene A.; Aguirre, Frank V.; Miller, Leslie W.; Donohue, Thomas J.

doi:10.1016/s0735-1097(96)00327-0

Cited by 162 publications

(91 citation statements)

References 30 publications

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“…Stratification of coronary flow impairments according to relative CFVR results assumes a uniform microcirculatory function. 16 However, this might not be the case even in patients with single-vessel disease. 17 …”

Section: Impaired Cfvr After Angioplasty In Relation To Clinical Outcomementioning

confidence: 99%

Coronary Flow Velocity Reserve After Percutaneous Interventions Is Predictive of Periprocedural Outcome

et al. 2002

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Background-Because heterogeneous results have been reported, we assessed coronary flow velocity changes in individuals who underwent percutaneous transluminal coronary angioplasty (PTCA) and examined their impact on clinical outcome. Methods and Results-As part of the Doppler Endpoints Balloon Angioplasty Trial Europe (DEBATE) II study, 379 patients underwent Doppler flow-guided angioplasty. All patients were evaluated according to their coronary flow velocity reserve (CFVR) results (Ն2.5 or Ͻ2.5) at the end of the procedure. A CFVR Ͻ2.5 after angioplasty was associated with an elevated baseline blood flow velocity in both the target artery and reference artery. CFVR before PTCA and CFVR in the reference artery were independent predictors of an optimal CFVR after balloon angioplasty (CFVR

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Section: Impaired Cfvr After Angioplasty In Relation To Clinical Outcomementioning

confidence: 99%

Coronary Flow Velocity Reserve After Percutaneous Interventions Is Predictive of Periprocedural Outcome

et al. 2002

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“…4 -6 The basal flow velocities in both LAD and RCA in this study are lower than what has been reported in previous studies in children of comparable age and in adults, and this speaks strongly against increased coronary blood flow at rest. 8,10,14 The peak systolic flow velocity was higher in the RCA than in the LAD (22.0 cm/s versus 15.0 cm/s) in our subjects. This agrees well with earlier animal studies, and may be explained by lower systolic pressure and lower intramyocardial resistance against coronary flow in the right ventricle.…”

Section: Discussionmentioning

confidence: 51%

“…8,10,14,15 PET studies have indicated that myocardial blood flow at rest may be increased in subjects operated for TGA with the ASO. 4 -6 The basal flow velocities in both LAD and RCA in this study are lower than what has been reported in previous studies in children of comparable age and in adults, and this speaks strongly against increased coronary blood flow at rest.…”

Section: Discussionmentioning

confidence: 99%

“…4,6,17,20 It is well established that the normal adult heart can increase coronary flow/myocardial perfusion maximally by 2.5 to 4 times the resting value, but normal CFR values are different for each method and vasodilator used. 4,10,20,21 Cardiac sympathetic nerves play a part in modulating the function of the coronary arteries. 22 The ASO causes a loss of coronary adrenergic nerve supply, and it is conceivable that this might affect coronary vasoreactivity.…”

Section: Discussionmentioning

confidence: 99%

“…Adenosine has been shown to be superior to dipyridamole in inducing true maximal coronary flow, and normal values for CFR after adenosine injection are well established in adults. 3,10,21,28 The dose given (0.5 g adenosine/kg in both LAD and RCA) was estimated to be equivalent to the 12-and 18-g doses used for respective vessels in adults. We took care to be sure that we were achieving true maximal flow velocity by administrating double adenosine doses in the first patients, and this did not result in a higher CFR than the dose of 0.5 g/kg.…”

Section: Methodsmentioning

confidence: 99%

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Normal Coronary Flow Reserve After Arterial Switch Operation for Transposition of the Great Arteries

et al. 2002

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Background-Recent studies performed with positron emission tomography have suggested that coronary flow reserve (CFR) is moderately to severely reduced after the arterial switch operation (ASO). These findings are of great concern but have not been confirmed by other methods. Methods and Results-Eleven symptom-free children were studied between 4 and 11 (median 6.0) years after the ASO.Flow velocity in the left anterior descending (LAD) and right coronary arteries (RCA) was measured with a 0.014-inch Doppler FloWire (Cardiometrics) before and after intracoronary injection of adenosine (0.5 g/kg) and nitroglycerin (5 g/kg). CFR was defined as the ratio of hyperemic to basal average peak velocity (APV). The median (range) CFR in the LAD was 3.7 (3.0 to 4.8) and 3.4 (2.9 to 4.8) in the RCA. The increase in APV after intracoronary injection of nitroglycerin was 300% (240% to 420%) in the LAD and 260% (190% to 460%)

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Hemodynamic rounds series II: Coronary hemodynamics for angioplasty and stenting after myocardial infarction: Use of absolute, relative coronary velocity and fractional flow reserve

Kern

Puri

Craig

et al. 1998

Cathet. Cardiovasc. Diagn.

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Variations in normal coronary vasodilatory reserve stratified by artery, gender, heart transplantation and coronary artery disease

Abstract: These findings identify a normal reference range for studies assessing the coronary circulation and post-stenotic coronary vasodilatory reserve in patients with and without coronary artery disease encountered in the cardiac catheterization laboratory.

Cited by 162 publications

References 30 publications

Coronary Flow Velocity Reserve After Percutaneous Interventions Is Predictive of Periprocedural Outcome

Coronary Flow Velocity Reserve After Percutaneous Interventions Is Predictive of Periprocedural Outcome

Normal Coronary Flow Reserve After Arterial Switch Operation for Transposition of the Great Arteries

Hemodynamic rounds series II: Coronary hemodynamics for angioplasty and stenting after myocardial infarction: Use of absolute, relative coronary velocity and fractional flow reserve

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