The present study exhibits a critical outlook on the poverty and livelihood vulnerability of the fisherman community in the context of persistent water pollution of the Churni River. The logistic regression model has identified eight factors influencing the poverty of the study area while the entropy weight method identifies the livelihood vulnerability of the fishermen. The livelihood vulnerability index of the upper stretch of the river is higher (0.65-0.67) compared to that of the lower stretch (0.46-0.57). The typical spatiality in poverty and livelihood vulnerability is triggered by the fragility of fishing livelihoods in the wake of lower concentrations of dissolved oxygen (DO), and higher BOD, COD, ammonia, nitrate and phosphate mainly due to industrial water pollution. For example, average DO ranges from 1.65 mg/l (upper stretch) to 2.50 mg/l (lower stretch) while the average BOD ranges from 5.44 mg/l (lower stretch) to 9.42 mg/l (upper stretch). This pollution induces acute ecological stress concerning declining fish diversity (from 41 to 16 fish species at the upper stretch and 41 to 23 fish species at the lower stretch during 1980-2018) as well as productivity of the existing fish species. Therefore, paralysed fishing economy and high dependency of the fishermen on the Churni River have forced them to revolve into the vicious cycle of poverty and enduring fragile livelihoods. Thus, the fishermen adopt few coping strategies like access to the nearby wetland for fishing, diversity in earning strategy and environmental movements against pollution to reduce the intensity of vulnerability. The present study would help the regional planners to frame the participatory plans for the sustainability of the riverine ecology and economy.