Variations in Progression and Regression of Precancerous Lesions of the Uterine Cervix on Cytology Testing Among Women of Different Races

Martingano, Daniel; Renson, Audrey; Martingano, Alison Jane; Martingano, Francis X.

doi:10.7556/jaoa.2018.003

Cited by 3 publications

(6 citation statements)

References 33 publications

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“…16,17 Among various racial groups in the US, the black race was found to have the slowest expected times for lesion regression (49 months; 95% CI, 29.1-86.2). 18 The highest regression rate (62%) in our study was among women whose follow-up exam was more than one year after their initial exam, most of whom were followed up within two years. Our data indicate that less than 10% of VIA/VILI lesions regress within 90 days of examination.…”

Section: Discussionmentioning

confidence: 53%

<p>Factors Associated with Treatment Uptake Among Women with Acetic Acid/Lugol’s Iodine Positive Lesions of the Cervix in Cameroon</p>

Manga

Shi

Welty

et al. 2020

IJWH

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Purpose: Treatment of cervical precancer is the primary aim in secondary prevention of cervical cancer. The purpose of this study was to examine factors associated with treatment uptake among women with acetic acid/Lugol's iodine positive lesions identified by digital cervicography (DC) in a cervical cancer prevention program in Cameroon. Patients and Methods: We conducted a cross-sectional survey of medical records from 2013 to 2018 of 755 women in Cameroon who screened positive with acetic acid/Lugol's iodine in 2013. Results: Of the 755 women, 422 (55.9%) had treatment/biopsy on the same day or followed up later, but only 344 (45.6%) received treatment/biopsy and 333 (44.1%) were lost to follow-up. Overall, 180 (52.3%) of the 344 women were treated/biopsied the same day they were screened, and 164 (47.7%) were treated/biopsied after the initial visit. Women aged 30-49 and HIV-positive women were significantly more likely to have received treatment or returned for treatment than women less than 30 and HIV-negative women. Of the 266 women who followed up at a later date, the lesions of 78 (29.3%) women regressed spontaneously without treatment. Women with low-grade lesions, HIV-negative women and women who had follow-up more than a year after the initial exam were significantly more likely to have spontaneous regression with regression rates of 30.6%, 32.1% and 62.2%, respectively (p<0.001). Age was not a significant determinant of spontaneous regression (p=0.149). Conclusion: Efforts to increase treatment uptake are needed in this population, including adherence to same day "See and treat" policies.

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Section: Discussionmentioning

confidence: 53%

<p>Factors Associated with Treatment Uptake Among Women with Acetic Acid/Lugol’s Iodine Positive Lesions of the Cervix in Cameroon</p>

Manga

Shi

Welty

et al. 2020

IJWH

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“…Our results are consistent as we had a high proportion of biopsy-confirmed ASCUS progression in 47% of the cases. Additionally, our ASCUS results, in particular, showed a slow progression to LSIL in subsequent controls; this progression time could be affected by ethnicity, as Hispanic patients have shown a slower progression from ASCUS to LSIL than Asian, African-American and Caucasian patients [17].…”

Section: Discussionmentioning

confidence: 61%

“…Although there have been numerous previous national cohort study follow-ups on lesion of approximately 12 years [14][15][16][17], there have also been follow-up studies that have only looked at a limited fraction of accessible cytologies due to a lack of comprehensive data for a proper progression analysis [9,10]. Our analyses in a largest tertiary-care women's hospital in Peru have also focused on a group of cases (156/10,385 patients) with follow-up, similar to previous reports in Nepal (75/1,922 patients) and Italy (24/264 patients) [9,10].…”

Section: Discussionmentioning

confidence: 99%

“…However, Hispanics also demonstrated a faster progression rate from LSIL to HSIL compared to all other racial categories. The lowest regression rate from LSIL to ASCUS was also reported for Hispanics [17]. In the Latin American population, a 1% progression rate for HSIL has been reported [12], with a higher risk of CIN 3 in those over 60 years of age (42.8%) [20].…”

Section: Discussionmentioning

confidence: 99%

“…Patients with results of cytological alteration or monitored precancerous lesions were included in the study. Patients who underwent complete excisional surgeries were omitted since this might skew the results of actual precancerous lesion regression or progression [17]. Data included the date and type of diagnosis, the age of the patients, and subsequent test results within three months.…”

Section: Inclusion Of Patients and Variablesmentioning

confidence: 99%

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Evaluation of Three Models of Follow-up of Patients with Cervical Cytological Abnormalities in a Peruvian’s Largest Teaching Women’s Hospital

et al. 2022

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The follow-up of squamous intraepithelial lesions (SIL) allows us to understand their progression and regression, however squamous cell atypia (ASC) can generate confusing follow-up results. We aimed to describe the evolution of ASC and SIL during cyto-histopathological follow-up in a tertiary-care hospital.Materials and methods: we conducted a retrospective study during 2016 in 156 Papanicolaou test (PAP) results under three models: 1) with ≥1 PAP and biopsies, 2) 1 PAP followed by ≥1 biopsy, and 3) ≥1 PAP and a confirmatory biopsy. Progression was defined as ASCUS to low-grade SIL (LSIL) or higher, and LSIL to high-grade SIL (HSIL) or higher; and regression as HSIL to LSIL or lower; and LSIL to ASCUS or lower. Results:In PAP, 57 (36.5%) cases were ASC and in histopathology 56 (39.9%) cases of grade 1 cervical intraepithelial neoplasia. Twenty-nine (18.6%) results were followed: 8 (27.6%), 17 (58.6%), and 4 (13.8%) with models 1, 2, and 3, respectively. The progression of the lesions was reported in ~50% for models 2 and 3. ASCUS was the main cytological finding that indicated biopsies, and for all models, the mean progression and regression time was 4 and 3.1 months, respectively. Conclusions:The follow-up of cytological alterations in three models showed progression of lesions in half of the cases analyzed with a time of four months of evolution; ASCUS was the main finding that indicated histopathological study.

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Cervical Dysplasia

Sadlon¹,

Murray²

2020

Textbook of Natural Medicine

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Variations in Progression and Regression of Precancerous Lesions of the Uterine Cervix on Cytology Testing Among Women of Different Races

Abstract: Variations in precancerous lesions of the uterine cervix are not uniform across races.

Cited by 3 publications

References 33 publications

<p>Factors Associated with Treatment Uptake Among Women with Acetic Acid/Lugol’s Iodine Positive Lesions of the Cervix in Cameroon</p>

<p>Factors Associated with Treatment Uptake Among Women with Acetic Acid/Lugol’s Iodine Positive Lesions of the Cervix in Cameroon</p>

Evaluation of Three Models of Follow-up of Patients with Cervical Cytological Abnormalities in a Peruvian’s Largest Teaching Women’s Hospital

Cervical Dysplasia

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