Variations in salicylamide glucuronide formation in normal and in G-6-PD-deficient children

Cassimos, Chr.; K, Malaka-Zafiriu; Tsiures, T.; Danielides, B

doi:10.1016/s0022-3476(74)80566-4

Cited by 11 publications

(3 citation statements)

References 2 publications

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“…The results of both methods were comparable. The reproducibility of our methods are mentioned in previous studies (Cassimos et al 1974, Cassimos et al 1974, Malaka-Zafiriu et al 1973, Malaka-Zafiriu et al 1975. 600 mg salicylamide was given by mouth followed by collection of urlne over a period of 30 hours.…”

Section: Methodssupporting

confidence: 61%

Pharmacology of Antibiotics

Molitor¹

1976

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Section: Methodssupporting

confidence: 61%

Pharmacology of Antibiotics

Molitor¹

1976

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“…Further studies [8] suggest that favism may be a multifactorial syndrome in which both intra-and extraerythrocytic factors concur. With regard to the latter, Cassimos et al [14] found that favic subjects had impaired liver capacity in the glucuronization of salicylamide. This aspect was confirmed by Cutillo et al [15] who showed a family incidence of the defect.…”

Section: Discussionmentioning

confidence: 99%

Favism and Hemolytic Anemia in Glucose-6-Phosphate Dehydrogenase-Deficient Subjects in North Sardinia

et al. 1983

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The present paper reports the incidence from 1965 to 1979 of acute hemolytic anemia for a total of 948 cases in G-6-PD-deficient subjects due to the ingestion of fresh or dried fava beans or certain drugs and to viral infections. The highest percentage of hemolytic crises was due to fresh fava beans (94.4%). No cases of favism were observed in breast-fed babies whose mothers had eaten fava beans or from pollen inhalation. The male sex proved to be the hardest hit. Hemoglobin values were lower than or equal to 7 g/dl in about 75% of males and 50% of females. Total bilirubin values were lower than 103 μmol/l (6 mg/dl) in about 75% of males and 85% of females. Both the hemoglobin and bilirubin values were statistically significant. Mean transaminase values (SGPT) were significantly higher than those of normal controls. No correlation between favism and blood groups was found.

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“…A reduced ability to form prothrombin has been observed by Vullo and Panizon [1], and a reduced ability to form salicylamide glucuronide has been demonstrated by Cassimos et al [2] and Cutillo et al [3], Liver histology revealed cloudy and vacuole de generation of the hepatocyte cytoplasm [1],…”

mentioning

confidence: 99%

Serum Glutamic Oxalacetic Transaminase, Glutamic Pyruvic Transaminase, Gamma-Glutamyl Transpeptidase and Glutamic Dehydrogenase Levels in Favism

Meloni¹,

Pilo²,

Gallisai³

et al. 1979

Acta Haematol

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Serum GOT, GPT, γ-GT and GLDH were determined in 15 G-6-PD-deficient subjects during a hemolytic crisis and hemoglobinuria due to ingestion of fresh fava beans. The same G-6-PD-deficient subjects were studied again 2 months after the crisis, when they were asymptomatic. 15 normal healthy children served as controls. A statistically significant increase, above normal, in serum GOT, GLDH and γ-GT was observed in the favic subjects during the crisis. All the values reverted to normal in the asymptomatic period.

show abstract

Variations in salicylamide glucuronide formation in normal and in G-6-PD-deficient children

Cited by 11 publications

References 2 publications

Pharmacology of Antibiotics

Pharmacology of Antibiotics

Favism and Hemolytic Anemia in Glucose-6-Phosphate Dehydrogenase-Deficient Subjects in North Sardinia

Serum Glutamic Oxalacetic Transaminase, Glutamic Pyruvic Transaminase, Gamma-Glutamyl Transpeptidase and Glutamic Dehydrogenase Levels in Favism

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