Variations in strength of vertebrae with age and their relation to osteoporosis

Bell, G. H.; Dunbar, Olive; Beck, J. Swanson; Gibb, Andrew

doi:10.1007/bf02008077

Cited by 326 publications

(101 citation statements)

References 12 publications

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“…The conventional view is that a compressive load on vertebrae is mainly carried by the vertical trabeculae, whereas the horizontal trabeculae serve to prevent buckling of the vertical trabeculae [34,35] . This view is reinforced by finite element analyses of human vertebral bone specimens, which demonstrates that vertical trabeculae are more highly strained than horizontal ones under normal compressive loading, the [14,36] .…”

Section: Vertebramentioning

confidence: 99%

Bone three-dimensional microstructural features of the common osteoporotic fracture sites

Chen

Kubo

2014

WJO

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Osteoporosis is a common metabolic skeletal disorder characterized by decreased bone mass and deteriorated bone structure, leading to increased susceptibility to fractures. With aging population, osteoporotic fractures are of global health and socioeconomic importance. The three-dimensional microstructural information of the common osteoporosis-related fracture sites, including vertebra, femoral neck and distal radius, is a key for fully understanding osteoporosis pathogenesis and predicting the fracture risk. Low vertebral bone mineral density (BMD) is correlated with increased fracture of the spine. Vertebral BMD decreases from cervical to lumbar spine, with the lowest BMD at the third lumbar vertebra. Trabecular bone mass of the vertebrae is much lower than that of the peripheral bone. Cancellous bone of the vertebral body has a complex heterogeneous three-dimensional microstructure, with lower bone volume in the central and anterior superior regions. Trabecular bone quality is a key element to maintain the vertebral strength. The increased fragility of osteoporotic femoral neck is attributed to low cancellous bone volume and high compact porosity. Compared with age-matched controls, increased cortical porosity is observed at the femoral neck in osteoporotic fracture patients. Distal radius demonstrates spatial inhomogeneous characteristic in cortical microstructure. The medial region of the distal radius displays the highest cortical porosity compared with the lateral, anterior and posterior regions. Bone strength of the distal radius is mainly determined by cortical porosity, which deteriorates with advancing age. Key words: Osteoporosis; Fracture; Microstructure; Trabecular bone; Cortical bone; Vertebra; Femoral neck; Distal radius Core tip: The most common sites of the osteoporotic fractures include the vertebra, femoral neck and distal radius, where the microstructural information is a key for fully understanding osteoporosis pathogenesis and improving the prediction of fracture risk. Vertebral strength is mostly preserved by trabecular bone, which is microstructurally inhomogeneous, with lower bone volume in the central and anterior superior regions. Increased fragility of osteoporotic femoral neck is attributed to low cancellous bone volume and high compact porosity. Distal radius shows significant variations in cortical porosity, which is the major element attributed to bone strength of the distal radius.

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Section: Vertebramentioning

confidence: 99%

Bone three-dimensional microstructural features of the common osteoporotic fracture sites

Chen

Kubo

2014

WJO

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“…A close positive linear relationship has been found between the axial compressive strength and the amount ofbone mineral in human lumbar vertebrae (Bartley et al 1966, Bell et al 1967, Galante et al 1970, Hansson etal. 1980.Comparisons betweeninvi-.…”

Section: Granhed Ragnar Jonson and Tommy Hanssonmentioning

confidence: 99%

Mineral content and strength of lumbar vertebrae A cadaver study

Granhed

Jonson

Hansson

1989

Acta Orthopaedica Scandinavica

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“…For trabecular bone, the number and thickness of the trabeculae are decreased, and the size of the intertrabecular spaces increase (113)(114)(115)(116). As transverse struts of the trabecular become thinner and fail, the anisotropy increases with age (112,117), and the longitudinal struts become more likely to buckle (118). In addition, the mechanical integrity of the collagen network also degrades with aging (90).…”

Section: Mechanical Behaviour Of Trabecular Bonementioning

confidence: 99%

Experimental validation of finite element predicted bone strain in the human metatarsal

Fung

Loundagin

Edwards

2017

Journal of Biomechanics

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The objective of this study was to verify and validate a finite element modeling routine for the human metatarsal, which is a common location for stress fractures. Experimental strain measurements on 33 human cadaveric metatarsals subject to cantilever bending were compared with strain predictions from finite element (FE) models generated from computed tomography images. For the material property assignment of the FE models, a published density-elasticity relationship was compared with density-elasticity equations developed using optimization techniques. The correlations between the measured and predicted and predicted strains were very high (r 2 ≥0.94) for all of the density-elasticity equations. However, the utilization of an optimized density-elasticity equation improved the accuracy of the finite element models, reducing the maximum error between measured and predicted strains by 10% to 20%. The finite element modeling routine could be used for investigating potential interventions to minimize metatarsal strains and the occurrence of metatarsal stress fractures.iii

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Variations in strength of vertebrae with age and their relation to osteoporosis

Cited by 326 publications

References 12 publications

Bone three-dimensional microstructural features of the common osteoporotic fracture sites

Bone three-dimensional microstructural features of the common osteoporotic fracture sites

Mineral content and strength of lumbar vertebrae A cadaver study

Experimental validation of finite element predicted bone strain in the human metatarsal

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