Variations in T2-Mapping-Assessed Area at Risk After Experimental Ischemia/Reperfusion

Gómez-Talavera, Sandra; Fernández‐Jiménez, Rodrigo; Galán‐Arriola, Carlos; Agüero, Jaume; López-Martín, Gonzalo J.; González, Manuel Lobo; López-Ayala, Pedro; Vílchez-Tschischke, Jean Paul; Sánchez‐González, Javier; Ibáñez, Borja

doi:10.1007/s12265-021-10120-0

Cited by 2 publications

(2 citation statements)

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“…The current methods for evaluating the area at risk following I/R injury, which mainly include positron emission tomography /computed tomography with radionuclides such as sodium [18F] fluoride, [ 30 ] radionuclides labeled molecules with injured related phospholipids binding activities, [ 31 ] and T2‐weighted cardiac magnetic resonance imaging (T2‐CMR). [ 32 ] Major limitations of the first two methodologies include adverse effects to hazardous ionizing radiation, intrinsically limited spatial resolutions, reconstruction‐dependent poor temporal resolution, high cost and lack of both exogenous and endogenous probes for molecular or functional imaging. [ 33 ] The T2‐CMR is based on the edema at the injured sites.…”

Section: Discussionmentioning

confidence: 99%

Pharmaceutical Manipulation of Mitochondrial F0F1‐ATP Synthase Enables Imaging and Protection of Myocardial Ischemia/Reperfusion Injury Through Stress‐induced Selective Enrichment

Chen,

Tan,

Jin

et al. 2023

Advanced Science

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To rescue ischemic myocardium from progressing to myocardial infarction, timely identification of the infarct size and reperfusion is crucial. However, fast and accurate identification, as well as the targeted protection of injured cardiomyocytes following ischemia/reperfusion (I/R) injury, remain significantly challenging. Here, a near infrared heptamethine dye IR‐780 is shown that has the potential to quickly monitor the area at risk following I/R injury by selectively entering the cardiomyocytes of the at‐risk heart tissues. Preconditioning with IR‐780 or timely IR‐780 administration before reperfusion significantly protects the heart from ischemia and oxidative stress‐induced cell death, myocardial remodeling, and heart failure in both rat and pig models. Furthermore, IR‐780 can directly bind to F0F1‐ATP synthase of cardiomyocytes, rapidly decrease the mitochondrial membrane potential, and subsequently slow down the mitochondrial energy metabolism, which induces the mitochondria into a “quiescent state” and results in mitochondrial permeability transition pore inhibition by preventing mitochondrial calcium overload. Collectively, the findings show the feasibility of IR‐780‐based imaging and protection strategy for I/R injury in a preclinical context and indicate that moderate mitochondrial function depression is a mode of action that can be targeted in the development of cardioprotective reagents.

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Section: Discussionmentioning

confidence: 99%

Pharmaceutical Manipulation of Mitochondrial F0F1‐ATP Synthase Enables Imaging and Protection of Myocardial Ischemia/Reperfusion Injury Through Stress‐induced Selective Enrichment

Chen,

Tan,

Jin

et al. 2023

Advanced Science

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“…Native T1 mapping can identify myocardial fibrosis and quantify IS without utilizing gadolinium agents ( 13 – 15 ), which gives an estimate of IS for particular patient groups. A high T2 signal reflects an increased myocardial water content; T2 mapping is confirmed effective in assessing myocardial edema, which is considered as AAR in AMI ( 16 ). Comparing and quantifying T1 and T2 mapping ideally provide MSI and assess reperfusion efficacy.…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of myocardial salvage assessed by cardiac magnetic resonance in reperfused ST-segment elevation myocardial infarction

Wang

et al. 2022

Front. Cardiovasc. Med.

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AimsMyocardial salvage index (MSI) is attracting increasing attention for predicting prognosis in acute myocardial infarction (AMI); however, the evaluation of MSI is mainly based on contrast agent-dependent cardiac magnetic resonance (CMR) scanning sequences. This study aims to investigate the prognostic value of MSI in reperfused ST-segment elevation myocardial infarction (STEMI) through the contrast agent-free CMR technique.Methods and resultsNighty-two patients with acute STEMI, who underwent CMR after primary percutaneous coronary intervention (PPCI), were finally enrolled. Patients were subcategorized into two groups according to median MSI. T1 and T2 mapping were conducted for measuring infarct size (IS) and area at risk (AAR). IS was significantly larger in < median MSI group than ≥ median MSI group (P < 0.001). AAR between the two groups showed no obvious differences (P = 0.108). Left ventricular ejection fraction (LVEF) was lower in < median MSI group than ≥ median MSI group (P = 0.014). There was an obvious inverse correlation between MSI and reperfusion time (R = –0.440, P < 0.001) and a strong inverse correlation between MSI and IS (R = –0.716, P = 0.011). As for the relationship LVEF, MSI showed positive but weak correlation (R = 0.2265, P < 0.001). Over a median follow-up period of 263 (227–238) days, prevalence of MACEs was significantly higher in the < median MSI group [HR: 0.15 (0.04–0.62); Log-rank P = 0.008]. The univariate Cox regression analysis revealed that LVEF, IS, and MSI were significant predictors for major adverse cardiovascular events (MACEs) (all P < 0.05). In the stepwise multivariate Cox regression analysis, LVEF and MSI were identified as independent parameters for predicting MACEs (both P < 0.05). In the receiver-operating characteristic analysis, LVEF, IS, and MSI showed prognostic value in predicting MACEs with AUCs of 0.809, 0.779, and 0.896, respectively, all (P < 0.05). A combination of MSI with LVEF showed the strongest prognostic value of MACEs (AUC: 0.901, sensitivity: 77.78%, specificity: 98.80%, P < 0.001). Delong’s test showed that the combination of LVEF with MSI had an incremental value than LVEF itself in predicting MACEs (P = 0.026).ConclusionContrast agent-free CMR technique provides a reliable evaluation of MSI, which contributes to assessing the efficacy of reperfusion therapy and predicting the occurrence of MACEs.

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Variations in T2-Mapping-Assessed Area at Risk After Experimental Ischemia/Reperfusion

Cited by 2 publications

References 5 publications

Pharmaceutical Manipulation of Mitochondrial F0F1‐ATP Synthase Enables Imaging and Protection of Myocardial Ischemia/Reperfusion Injury Through Stress‐induced Selective Enrichment

Pharmaceutical Manipulation of Mitochondrial F0F1‐ATP Synthase Enables Imaging and Protection of Myocardial Ischemia/Reperfusion Injury Through Stress‐induced Selective Enrichment

Prognostic significance of myocardial salvage assessed by cardiac magnetic resonance in reperfused ST-segment elevation myocardial infarction

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