Variations in the Gut Microbiota in Breast Cancer Occurrence and Bone Metastasis

Yu, Weikuan; Xie, Zhen; Chen, Kai; Cai, Zhaopeng; Jinteng, Li; Mengjun, Ma; Zepeng, Su; Yunshu, Che; Wang, Peng; Wu, Yanfeng; Shen, Huiyong

doi:10.3389/fmicb.2022.894283

Cited by 22 publications

(18 citation statements)

References 52 publications

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“…Consistent with this, the gut microbiota is different between individuals with cancer, including breast cancer, and those who are cancer free 97,98 . A recent study reported a lack of Megamonas and Akkermansia in the gut microbiota in metastatic breast cancer patients, compared with non‐metastatic patients 99 . In the same study, it was also reported that the gut microbiota composition in metastatic breast cancer patients was predictive of changes in lipid transportation and metabolism and folate biosynthesis 99 .…”

Section: Gut Microbiota and Breast Cancermentioning

confidence: 81%

“… 99 In the same study, it was also reported that the gut microbiota composition in metastatic breast cancer patients was predictive of changes in lipid transportation and metabolism and folate biosynthesis. 99 However, these differences mostly reflect cancer‐induced changes in the microbiota rather than changes, which cause cancer.…”

Section: Gut Microbiota and Breast Cancermentioning

confidence: 93%

“…A recent study reported a lack of Megamonas and Akkermansia in the gut microbiota in metastatic breast cancer patients, compared with non‐metastatic patients 99 . In the same study, it was also reported that the gut microbiota composition in metastatic breast cancer patients was predictive of changes in lipid transportation and metabolism and folate biosynthesis 99 . However, these differences mostly reflect cancer‐induced changes in the microbiota rather than changes, which cause cancer.…”

Section: Gut Microbiota and Breast Cancermentioning

confidence: 99%

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Maternal obesity and resistance to breast cancer treatments among offspring: Link to gut dysbiosis

2022

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Background: About 50 000 new cases of cancer in the United States are attributed to obesity. The adverse effects of obesity on breast cancer may be most profound when affecting the early development; that is, in the womb of a pregnant obese mother. Maternal obesity has several long-lasting adverse health effects on the offspring, including increasing offspring's breast cancer risk and mortality. Gut microbiota is a player in obesity as well as may impact breast carcinogenesis. Gut microbiota is established early in life and the microbial composition of an infant's gut becomes permanently dysregulated because of maternal obesity. Metabolites from the microbiota, especially short chain fatty acids (SCFAs), play a critical role in mediating the effect of gut bacteria on multiple biological functions, such as immune system, including tumor immune responses.Recent Findings: Maternal obesity can pre-program daughter's breast cancer to be more aggressive, less responsive to treatments and consequently more likely to cause breast cancer related death. Maternal obesity may also induce poor response to immune checkpoint inhibitor (ICB) therapy through increased abundance of inflammation associated microbiome and decreased abundance of bacteria that are linked to production of SCFAs. Dietary interventions that increase the abundance of bacteria producing SCFAs potentially reverses offspring's resistance to breast cancer therapy. Conclusion:Since immunotherapies have emerged as highly effective treatments for many cancers, albeit there is an urgent need to enlarge the patient population who will be responsive to these treatments. One of the factors which may cause ICB refractoriness could be maternal obesity, based on its effects on the microbiota markers of ICB therapy response among the offspring. Since about 40% of children are born to obese mothers in the Western societies, it is important to determine if maternal obesity impairs offspring's response to cancer immunotherapies.

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Section: Gut Microbiota and Breast Cancermentioning

confidence: 81%

Section: Gut Microbiota and Breast Cancermentioning

confidence: 93%

Section: Gut Microbiota and Breast Cancermentioning

confidence: 99%

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Maternal obesity and resistance to breast cancer treatments among offspring: Link to gut dysbiosis

2022

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“…Wenhui and colleagues [ 166 ] compared the GM profiles from breast cancer patients with no metastasis (w/oBMs) , breast cancer patients with bone metastasis (BMs) and control individuals (Cs). They found that the community diversity was the lowest in patients with BMs.…”

Section: The Relationship Between Gut Microbiome and Bone-related Dis...mentioning

confidence: 99%

Roles of Gut Microbiome in Bone Homeostasis and Its Relationship with Bone-Related Diseases

Zemanová

Omelka

Mondockova

et al. 2022

Biology

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The extended microbial genome—the gut microbiome (GM)—plays a significant role in host health and disease. It is able to influence a number of physiological functions. During dysbiosis, GM is associated with the development of various chronic diseases with impaired bone quality. In general, GM is important for bone homeostasis and can affect it via several mechanisms. This review describes the roles of GM in bone homeostasis through influencing the immune and endocrine functions, short-chain fatty acids production, calcium absorption and the gut–brain axis. The relationship between GM composition and several bone-related diseases, specifically osteoporosis, osteoarthritis, rheumatoid arthritis, diabetes mellitus, obesity and bone cancer, is also highlighted and summarized. GM manipulation may become a future adjuvant therapy in the prevention of many chronic diseases. Therefore, the beneficial effects of probiotic therapy to improve the health status of individuals with aforementioned diseases are provided, but further studies are needed to clearly confirm its effectiveness. Recent evidence suggests that GM is responsible for direct and indirect effects on drug efficacy. Accordingly, various GM alterations and interactions related to the treatment of bone-related diseases are mentioned as well.

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“…Cultivable bacteria with broad microbial viability have been found in mammary tumor tissues, and depletion of intratumor bacteria reduces breast cancer metastasis ( 11 – 13 ). Moreover, the complex interaction of microbiota and steroid hormone has a influence on bone metastasis of breast cancer ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

Integrating bulk and single-cell RNA sequencing data reveals the relationship between intratumor microbiome signature and host metabolic heterogeneity in breast cancer

et al. 2023

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IntroductionNowadays, it has been recognized that gut microbiome can indirectly modulate cancer susceptibility or progression. However, whether intratumor microbes are parasitic, symbiotic, or merely bystanders in breast cancer is not fully understood. Microbial metabolite plays a pivotal role in the interaction of host and microbe via regulating mitochondrial and other metabolic pathways. And the relationship between tumor-resident microbiota and cancer metabolism remains an open question.Methods1085 breast cancer patients with normalized intratumor microbial abundance data and 32 single-cell RNA sequencing samples were retrieved from public datasets. We used the gene set variation analysis to evaluate the various metabolic activities of breast cancer samples. Furthermore, we applied Scissor method to identify microbe-associated cell subpopulations from single-cell data. Then, we conducted comprehensive bioinformatic analyses to explore the association between host and microbe in breast cancer.ResultsHere, we found that the metabolic status of breast cancer cells was highly plastic, and some microbial genera were significantly correlated with cancer metabolic activity. We identified two distinct clusters based on microbial abundance and tumor metabolism data. And dysregulation of the metabolic pathway was observed among different cell types. Metabolism-related microbial scores were calculated to predict overall survival in patients with breast cancer. Furthermore, the microbial abundance of the specific genus was associated with gene mutation due to possible microbe-mediated mutagenesis. The infiltrating immune cell compositions, including regulatory T cells and activated NK cells, were significantly associated with the metabolism-related intratumor microbes, as indicated in the Mantel test analysis. Moreover, the mammary metabolism-related microbes were related to T cell exclusion and response to immunotherapy.ConclusionsOverall, the exploratory study shed light on the potential role of the metabolism-related microbiome in breast cancer patients. And the novel treatment will be realized by further investigating the metabolic disturbance in host and intratumor microbial cells.

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Variations in the Gut Microbiota in Breast Cancer Occurrence and Bone Metastasis

Cited by 22 publications

References 52 publications

Maternal obesity and resistance to breast cancer treatments among offspring: Link to gut dysbiosis

Maternal obesity and resistance to breast cancer treatments among offspring: Link to gut dysbiosis

Roles of Gut Microbiome in Bone Homeostasis and Its Relationship with Bone-Related Diseases

Integrating bulk and single-cell RNA sequencing data reveals the relationship between intratumor microbiome signature and host metabolic heterogeneity in breast cancer

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