Variations in the oral microbiome are associated with depression in young adults

Wingfield, Benjamin; Lapsley, Coral; McDowell, Andrew; Miliotis, Georgios; McLafferty, Margaret; O’Neill, Siobhan; Coleman, Sonya; McGinnity, TM; Bjourson, Anthony J.; Murray, Elaine

doi:10.1038/s41598-021-94498-6

Cited by 65 publications

(52 citation statements)

References 51 publications

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“… 281 In a depression-related study, 1S rRNA gene-based next-generation sequencing was used to profile the bacterial composition of saliva in depressed patients compared with young adults; it has shown diversification but importantly, increased Prevotella nigrescens and Neisseria was observed in depressed individuals. 282 Smoking and alcohol consumption are two major factors that induce dysbiosis in oral microbiota and promote growth of pathogenic bacteria. 280 A meta-analysis study has revealed that drinking alcohol is associated with pathogenesis of AD and also with significantly decreased level in Firmicutes phyla and an increased level in Bacteroides phyla in these patients.…”

Section: Microbiota In the Development Of Diseasesmentioning

confidence: 99%

Microbiota in health and diseases

Hou

Chen

et al. 2022

Sig Transduct Target Ther

1,164

426

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The role of microbiota in health and diseases is being highlighted by numerous studies since its discovery. Depending on the localized regions, microbiota can be classified into gut, oral, respiratory, and skin microbiota. The microbial communities are in symbiosis with the host, contributing to homeostasis and regulating immune function. However, microbiota dysbiosis can lead to dysregulation of bodily functions and diseases including cardiovascular diseases (CVDs), cancers, respiratory diseases, etc. In this review, we discuss the current knowledge of how microbiota links to host health or pathogenesis. We first summarize the research of microbiota in healthy conditions, including the gut-brain axis, colonization resistance and immune modulation. Then, we highlight the pathogenesis of microbiota dysbiosis in disease development and progression, primarily associated with dysregulation of community composition, modulation of host immune response, and induction of chronic inflammation. Finally, we introduce the clinical approaches that utilize microbiota for disease treatment, such as microbiota modulation and fecal microbial transplantation.

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Section: Microbiota In the Development Of Diseasesmentioning

confidence: 99%

Microbiota in health and diseases

Hou

Chen

et al. 2022

Sig Transduct Target Ther

1,164

426

View full text Add to dashboard Cite

show abstract

“…Wingfield et al compared the salivary microbiome of adolescents with MDD and HCs and found that a total of 21 taxa of bacteria were more abundant and 19 others were less abundant in MDD patients. The most abundant genera in the patient group were Prevotella nirescens and Neisseria [99]. Another study focused on the diversity of bacterial taxa, but the results showed that the composition, rather than diversity, mattered when associating with depression or anxiety symptoms in young adults.…”

Section: Gi Biomarkers and Pediatric Depressive Disordermentioning

confidence: 99%

Molecular Biomarkers for Pediatric Depressive Disorders: A Narrative Review

Lee

Chi

Lee

2021

IJMS

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Depressive disorder in childhood and adolescence is a highly prevalent mood disorder that tends to recur throughout life. Untreated mood disorders can adversely impact a patient’s quality of life and cause socioeconomic loss. Thus, an accurate diagnosis and appropriate treatment is crucial. However, until now, diagnoses and treatments were conducted according to clinical symptoms. Objective and biological validation is lacking. This may result in a poor outcome for patients with depressive disorder. Research has been conducted to identify the biomarkers that are related to depressive disorder. Cumulative evidence has revealed that certain immunologic biomarkers including brain-derived neurotrophic factor (BDNF) and cytokines, gastrointestinal biomarkers, hormones, oxidative stress, and certain hypothalamus-pituitary axis biomarkers are associated with depressive disorder. This article reviews the biomarkers related to the diagnosis and treatment of pediatric depressive disorders. To date, clinical biomarker tests are not yet available for diagnosis or for the prediction of treatment prognosis. However, cytokines such as Interleukin-2, interferon-gamma, tumor necrosis factor-alpha, and BDNF have shown significant results in previous studies of pediatric depressive disorder. These biomarkers have the potential to be used for diagnosis, prognostic assessment, and group screening for those at high risk.

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“…( 102 ), suggesting that oral microbiome composition can be associated with adolescent anxiety and depression symptoms. In addition, Wingfield et al ( 103 ), detecting the structure and composition of the salivary microbiome in young MDD adults as compared with control subjects, evidenced that a total of 21 bacterial taxa were differentially abundant in the depressed cohort, including increased Neisseria spp. and Prevotella nigrescens , while 19 taxa had a decreased abundance.…”

Section: Introductionmentioning

confidence: 99%

The Complex Molecular Picture of Gut and Oral Microbiota–Brain-Depression System: What We Know and What We Need to Know

et al. 2021

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Major depressive disorder (MDD) is a complex mental disorder where the neurochemical, neuroendocrine, immune, and metabolic systems are impaired. The microbiota-gut-brain axis is a bidirectional network where the central and enteric nervous systems are linked through the same endocrine, immune, neural, and metabolic routes dysregulated in MDD. Thus, gut-brain axis abnormalities in MDD patients may, at least in part, account for the symptomatic features associated with MDD. Recent investigations have suggested that the oral microbiome also plays a key role in this complex molecular picture of relationships. As on one hand there is a lot of what we know and on the other hand little of what we still need to know, we structured this review focusing, in the first place, on putting all pieces of this complex puzzle together, underlying the endocrine, immune, oxidative stress, neural, microbial neurotransmitters, and metabolites molecular interactions and systems lying at the base of gut microbiota (GM)–brain-depression interphase. Then, we focused on promising but still under-explored areas of research strictly linked to the GM and potentially involved in MDD development: (i) the interconnection of GM with oral microbiome that can influence the neuroinflammation-related processes and (ii) gut phageome (bacteria-infecting viruses). As conclusions and future directions, we discussed potentiality but also pitfalls, roadblocks, and the gaps to be bridged in this exciting field of research. By the development of a broader knowledge of the biology associated with MDD, with the inclusion of the gut/oral microbiome, we can accelerate the growth toward a better global health based on precision medicine.

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Variations in the oral microbiome are associated with depression in young adults

Cited by 65 publications

References 51 publications

Microbiota in health and diseases

Microbiota in health and diseases

Molecular Biomarkers for Pediatric Depressive Disorders: A Narrative Review

The Complex Molecular Picture of Gut and Oral Microbiota–Brain-Depression System: What We Know and What We Need to Know

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