Variations in the size of focal nodular hyperplasia on magnetic resonance imaging

Ramírez-Fuentes, Cristina; Martí‐Bonmatí, Luis; Torregrosa, Asunción; Val, Adolfo del; Martínez, C.

doi:10.1016/j.rxeng.2011.12.003

Cited by 7 publications

(3 citation statements)

References 19 publications

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“…If any significant interval changes are observed, an increased index of suspicion should prompt a liver biopsy for diagnostic confirmation at this point in time. Of note, a recent Spanish study reported their experience with sequential FNH MRI and found that 80% (of 44) FNH tumours were stable in size over time, 16% decreased in size, and only 4% increased in size (by double) . Unfortunately, serial follow‐up US data post‐FNH diagnosis was missing in greater than 50% of the cases in our cohort.…”

Section: Discussionmentioning

confidence: 99%

The role of diagnostic imaging and liver biopsy in the diagnosis of focal nodular hyperplasia in children

Valentino

Ling

et al. 2013

Liver International

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Section: Discussionmentioning

confidence: 99%

The role of diagnostic imaging and liver biopsy in the diagnosis of focal nodular hyperplasia in children

Valentino

Ling

et al. 2013

Liver International

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“…FNH is thought to represent a proliferative cell response to an aberrant dystrophic artery [40] and may be associated with other conditions characterized by arterial damage, such as hereditary haemorrhagic telangiectasia [41] or previously treated solid tumours in children [42]. Pregnancy and OCPs have not been demonstrated to play a role in development or progression of FNH [43][44][45].…”

Section: Hepatic Haemangiomamentioning

confidence: 99%

EASL Clinical Practice Guidelines on the management of benign liver tumours

Reeves¹

2016

Journal of Hepatology

398

183

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“…Ramírez-Fuentes et al [16] studied 30 patients with 44 presumed FNHs and observed that all 8 patients who initially had pain symptoms had spontaneous resolution unrelated to changes in lesion size. Similarly, Dardenne et al [14] also observed complete resolution of pain in all patients undergoing conservative treatment who, at the time of study inclusion, reported mild and nonspecific symptoms.…”

Section: Discussion/conclusionmentioning

confidence: 99%

Should Focal Nodular Hyperplasia Still be Operated Upon? Analysis of a Case Series

Amico

Souza

Trigueiro

et al. 2019

Dig Dis

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Background: Focal nodular hyperplasia (FNH) is a frequent benign liver lesion. Its course is considered benign, and there is no recommendation for its treatment. Nevertheless, the literature presents a high incidence of surgery. Aim: To evaluate the results of conservative treatment in a series of patients with presumed FNH. Methods: The study included patients diagnosed with FNH from May 2007 to July 2017 based on conventional imaging or magnetic resonance imaging with liver-specific contrast (MRI-LSC) or lesion biopsy (histology/immunohistochemical analysis). Patients were followed clinically and using imaging exams. Results: In a total of 54 patients, the diagnosis was obtained by typical findings on computed tomography scan and gadolinium MRI in 48.1% of the patients, by MRI-LSC in 31.5%, and by histological examination in 20.4% of cases. The mean follow-up time was 35.5 months. The initially asymptomatic patients remained symptom-free, and none of those with HNF-related pain had to worsen of the initial symptom. Conservative treatment was effective in 94.4% of the cases. In only 3 cases, there was a need for some therapeutic approach (5.5%); 2 cases for pain and 1 case for lesion growth during follow-up. Conclusion: The present study suggests that it is safe to conservatively manage patients with FNH presumed by highly accurate imaging tests. Similar to hepatic hemangiomas, surgery for FNH should be an exception.

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Variations in the size of focal nodular hyperplasia on magnetic resonance imaging

Cited by 7 publications

References 19 publications

The role of diagnostic imaging and liver biopsy in the diagnosis of focal nodular hyperplasia in children

The role of diagnostic imaging and liver biopsy in the diagnosis of focal nodular hyperplasia in children

EASL Clinical Practice Guidelines on the management of benign liver tumours

Should Focal Nodular Hyperplasia Still be Operated Upon? Analysis of a Case Series

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