Variations of 1-deoxyglucose(1,5-anhydroglucitol) content in plasma from patients with insulin-dependent diabetes mellitus.

Yoshioka, Shoichi; Saitoh, S; Negishi, Chie; Fujisawa, Tomomi; Fujimori, A; Takatani, Osamu; Imura, Mitsuo; Funabashi, Masuo

doi:10.1093/clinchem/29.7.1396

Cited by 32 publications

(7 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…But further researches need to be carried out, and more evidence needs to be investigated to confirm this hypothesis. Plasma concentration of 1,5-anhydroglucitol decreased in diabetic patients has been confirmed [ 11 , 12 ]. In order to eliminate interferences, diabetes patients were excluded in our research.…”

Section: Discussionmentioning

confidence: 94%

Metabolomics-Based Study of Clinical and Animal Plasma Samples in Coronary Heart Disease with Blood Stasis Syndrome

Zhao

Chen

Shi

et al. 2012

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

The aim of this study is to explore a bridge connecting the mechanism basis and macro syndromes of coronary heart disease with experimental animal models. GC-MS technique was used to detect the metabolites of plasma samples in mini swine models with myocardial infarction (MI) and patients with unstable angina (UA). 30 metabolites were detected in the plasma samples of more than 50 percent of model group and control group in swine, while 37 metabolites were found in the plasma samples of UA patients and healthy control group. 21 metabolites in the plasma samples of swine model and 20 metabolites in patients with UA were found of significant value. Among which, 8 shared metabolites were found of low level expression in both swine model and UA patients. Independent Student's t-test, principal component analysis (PCA), and hierarchicalcluster analysis (HCA) were orderly applied to comprehend inner rules of variables in the data. The 8 shared metabolites could take place of the 21 or 20 metabolites in classification of swine model with MI and UA patients, which could be considered as a bridge connecting the mechanism basis and macrosyndromes of swine model with MI and UA patients.

show abstract

Section: Discussionmentioning

confidence: 94%

Metabolomics-Based Study of Clinical and Animal Plasma Samples in Coronary Heart Disease with Blood Stasis Syndrome

Zhao

Chen

Shi

et al. 2012

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Based on these data, Japanese research groups in their studies have demonstrated a decrease in the concentration of 1,5-AG in serum in patients with hyperglycemia compared to patients in an euglycemic state. Studies have shown that measurements of 1,5-AG reflect glycemic status during the previous 48 h -2 weeks [15,16]. In addition, a gradual normalization of 1,5-AG values was demonstrated for patients responding to glucose lowering drug therapy [17].…”

Section: Introductionmentioning

confidence: 99%

1,5-Anhydroglucitol in type 2 diabetes mellitus patients with ST elevation myocardial infarction.

Sheryazdanova

Laryushina

2021

J CLIN MED KAZ

View full text Add to dashboard Cite

The study aimed to investigate the potential association of 1,5-AG and cardiovascular events in patients with type 2 diabetes mellitus.Material and methods: The study was an observational nonmatched case-control study. The study included 114 patients with type 2 diabetes mellitus; 42 were with STEMI (STEMI group) and 72 without STEMI (non-STEMI group). Clinical data, fasting blood glucose, HbA1c, and 1,5 Anhydro-D-glucitol were analyzed. The Mann-Whitney U-test and the χ2 test was used for categorical variables to assess the significance of differences between the groups. The binary logistic regression was used to determine the association of 1,5-AG and STEMI.Results: There were 43.86% men and 56.14% women among the investigated patients. The median age of patients in the STEMI and non-STEMI groups were 61 (Q25-75 54-71) and 53 (Q25-15 75 57-60) years of age, р=0.027. Median fasting plasma glycemia in the STEMI group was 9.81 mmol/l (Q25-75 7.7-14.8), in the non-STEMI group (8.55 mmol/l, Q25-75 6.72-10.07, р=0.012). 1,5-AG was significantly lower in the STEMI group than in the non-STEMI (the STEMI group: Ме=215.85, Q25-75 186.35-19 280.77; the non-STEMI group Ме=314.64, Q25-75 250.83-415.08, р=0.000). No significant difference in concentration of HbA1c was found between the groups. The logistic regression model adjusted on confounders demonstrated that low plasma 1,5-AG concentration increases the odds ratio of STEMI in diabetic patients [OR 3,217 (95% CI 2,732), p = 0,002]. Conclusion:The association between 1,5-AG and STEMI in patients with T2DM suggests the potential beneficial role of 1,5-AG as a cardiovascular risk marker in patients with type 2 diabetes mellitus.

show abstract

“…1,5-anhydro-D-glucitol (1,5AG) is one of the main polyols in the human body [18,27,32]. 1,5AG is produced from 1,5-anhydro-D-fructose (1,5AF) by a 1,5AF-specific NADPH-dependent reductase [2,19], and it is involved in carbon starvation signaling in the regulation of glycogen metabolism [10,19,21,24,33].…”

mentioning

confidence: 99%

Evaluation of Serum and Urine 1,5-Anhydro-D-Glucitol and Myo-Inositol Concentrations in Healthy Dogs

Miki

Mori

Hayakawa

et al. 2011

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

1,5-anhydro-D-glucitol (1,5AG) is a pyranoid polyol compound found in human circulating blood. Myo-inositol (MI) is a stereoisomer of inositol and serves as a precursor of inositol phospholipids. 1,5AG and MI are filtered by the glomerulus and almost completely reabsorbed through the renal tubules. However, under hyperglycemic conditions, reabsorption through the renal tubules is competitively inhibited because the structures of 1,5AG and MI resemble that of glucose. In this study, we investigated the kinetics of serum and urine 1,5AG and MI levels in healthy dogs. We demonstrated that 1,5AG and MI exist in canine serum and urine by gas chromatography-mass spectrometry. Under continuous hyperglycemic conditions, the serum 1,5AG concentration in healthy dogs decreased while the serum MI concentration remained unchanged. Urinary excretion of 1,5AG and MI increased significantly after blood glucose concentrations reached 200 to 220 mg/dl. A significant negative correlation was observed between serum 1,5AG and glucose concentrations during hyperglycemia. However, no significant correlation was observed between serum MI and glucose concentrations. In this study, we demonstrated that serum and urine 1,5AG and MI levels were changed by blood glucose concentrations. The serum 1,5AG concentration was decreased by continuous hyperglycemia. However, the serum MI concentration does not reflect hyperglycemia.

show abstract

Variations of 1-deoxyglucose(1,5-anhydroglucitol) content in plasma from patients with insulin-dependent diabetes mellitus.

Cited by 32 publications

References 2 publications

Metabolomics-Based Study of Clinical and Animal Plasma Samples in Coronary Heart Disease with Blood Stasis Syndrome

Metabolomics-Based Study of Clinical and Animal Plasma Samples in Coronary Heart Disease with Blood Stasis Syndrome

1,5-Anhydroglucitol in type 2 diabetes mellitus patients with ST elevation myocardial infarction.

Evaluation of Serum and Urine 1,5-Anhydro-D-Glucitol and Myo-Inositol Concentrations in Healthy Dogs

Contact Info

Product

Resources

About