Trace gases are important components for climate change process, and Earth's climate is sensitive to change in their atmospheric concentrations; therefore, proper assessment of trace gases is essential for ongoing global climate simulation. The spatio-temporal variations of four trace gases, namely carbon monoxide (CO), nitrogen dioxide (NO 2 ), ozone (O 3 ), and carbon dioxide (CO 2 ), over Bangladesh during the last decade are analysed using the remote-sensing data sets of the Atmospheric Infrared Sounder (AIRS) and Ozone Monitoring Instrument (OMI). Monthly, seasonal, and annual mean variations of trace gases were assessed. Higher CO, O 3 , and CO 2 concentrations show west-to-east gradient, indicating the impact of both local meteorology and emissions on variations in trace gases. On the other hand, total NO 2 concentration increases over Dhaka because of large population density, high traffic emission, larger industrial activities, and highly polluted air. The inter-annual variations of trace gases are mainly due to large-scale climatic phenomena such as El Niño and La Niña conditions. All the trace gases show strong seasonality, with higher levels during pre-monsoon season and lower levels during monsoon season, which are caused by the seasonal variations in biomass burning (BB), long-range transportation, and rainfall in South and Southeast Asia (S-SE Asia). However, O 3 concentration reveals minimum loading during winter season, associated with the reduction of O 3 formation in cold days due to insufficient heat. These findings are important to estimate regional climate variability due to trace gases.