Variations of plasma digoxin concentrations in the equilibrium state after multiple dosing.

Johnston, G D; McDevitt, DG

doi:10.1111/j.1365-2125.1978.tb01606.x

Cited by 10 publications

(4 citation statements)

References 4 publications

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“…Most of the infants had stable steady-state digoxin concentrations with a mean coefficient of variation of 9.4% which is comparable to that in adults [9], The effect of gestational age and body weight on steady-state digoxin level was examined by dividing the average steady-state digoxin level by the dose and plotting it against gestational age and body weight. An improve ment (25-30% in r2) in the correlation between the dose-normalized, steady-state level and gestational age/body weight was obtained when the dose was converted from mg/kg/day to mg/m2/day.…”

Section: Discussionmentioning

confidence: 99%

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Total Body Digoxin Clearance and Steady-State Concentrations in Low Birth Weight Infants

Rl¹,

Pk²,

Ma³

et al. 1982

Dev Pharmacol Ther

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Serial serum digoxin concentrations were measured over a 10-day period in 15 low birth weight infants requiring digoxin therapy. The calculated total body digoxin clearance (TBDC) was found to be highly dependent on gestational age and body weight, with dose-normalized, steady-state digoxin concentrations inversely related to the same factors. Because of the decreased TBDC in low birth weight infants, our data support the recent recommendations in the literaure to reduce maintenance doses of digoxin in these infants. Our study has further demonstrated that the reduction should be proportional to both gestational age and body weight.

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Section: Discussionmentioning

confidence: 99%

“…If the coefficient of variation was equal to or greater than 18%, the data of the infant were excluded from the final data analysis because a high coefficient of variation would denote a significant change in the overall digoxin clearance from day to day throughout the study [9].…”

Section: Methodsmentioning

confidence: 99%

Total Body Digoxin Clearance and Steady-State Concentrations in Low Birth Weight Infants

Rl¹,

Pk²,

Ma³

et al. 1982

Dev Pharmacol Ther

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“…We have previously shown that variations in steady-state plasma digoxin concentrations of greater than 0.5 nmol/1 (0.4 ng/ml) represent real changes in drug concentration provided they are not accompanied by changes in serum creatinine concentration of more than 32.2 ,tmol/1 (0.4 mg/100 ml) Johnston & McDevitt, 1978b). Changes in plasma digoxin concentrations of greater than 0.5 nmol/1 (0.4 Number of tablets prescribed ng/ml) in patients taking maintenance digoxin have been taken as evidence of non-compliance (Johnston & McDevitt, 1978a, b).…”

Section: Methodsmentioning

confidence: 99%

Does the frequency of daily dosage influence compliance with digoxin therapy?

Taggart¹,

Johnston²,

McDevitt³

1981

Brit J Clinical Pharma

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1 The influence of daily dosage frequency on drug compliance has been studied in 80 outpatients for whom maintenance digoxin 0.25 mg daily had been prescribed. 2 Each patient took one tablet (0.25 mg) daily, two tablets (0.125 mg) daily and four tablets (0.0625 mg) daily in randomised order for 2 month periods. 3 Compliance was assessed by tablet counting and by serial measurement of the plasma digoxin concentration.4 Of the 67 patients (100%) who could have completed the study, 19 (28.4%) were withdrawn for a variety of reasons; in the majority these were consistent with gross non-compliance. 5 The remaining 48 patients (71.6%) took significantly more tablets when prescribed once daily (98.5 + 1.0% of the total) or twice daily (96.4 + 1.6%) than when given four times daily (92.2 + 1.9%). However, there were no significant differences between the plasms digoxin levels obtained at the three dosage frequencies. 6 We conclude that the small improvement in compliance with once or twice daily dosage was clinically unimportant. Dosage frequency did not appear to have a major influence on the grossly non-compliant patients.

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“…From day 1 to day 8 these measurements indicated that the patients were in the equilibrium state with regard to digoxin therapy and renal function according to previously defined criteria (Johnston & McDevitt, 1978). Therefore, 'steady-state' plasma digoxin and serum creatinine concentrations were taken as the mean of those obtained on day 1 and day 8.…”

mentioning

confidence: 99%

Digoxin dosage regimens‐a comparison of intuitive and predicted digoxin prescribing [proceedings]

Johnston¹,

McDevitt²

1979

Brit J Clinical Pharma

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Variations of plasma digoxin concentrations in the equilibrium state after multiple dosing.

Cited by 10 publications

References 4 publications

Total Body Digoxin Clearance and Steady-State Concentrations in Low Birth Weight Infants

Total Body Digoxin Clearance and Steady-State Concentrations in Low Birth Weight Infants

Does the frequency of daily dosage influence compliance with digoxin therapy?

Digoxin dosage regimens‐a comparison of intuitive and predicted digoxin prescribing [proceedings]

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