Varicella-Associated Purpura Fulminans: Chicken Pox Is Not Always Benign

Abdulmalik, A; Al-Ateeqi, W; Al-Khawari, M; Alosaimi, Saud G

doi:10.1159/000092188

Cited by 7 publications

(7 citation statements)

References 21 publications

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“…Moreover, a case study on a 6-year-old boy highlighted the association of chickenpox with complications of purpura fulminans. [ 25 ] The child presented with purpura of the legs that rapidly progressed to other parts of the limbs and the buttocks. The authors suggested an early and aggressive treatment of postchickenpox purpura fulminans might reduce the mortality and morbidity associated with this condition.…”

Section: Kuwaitmentioning

confidence: 99%

“…The authors suggested an early and aggressive treatment of postchickenpox purpura fulminans might reduce the mortality and morbidity associated with this condition. [ 25 ] Another study highlighted an outbreak of chickenpox among susceptible staff in an Intensive Care Unit (ICU). [ 26 ] A 4-year-old child diagnosed with chickenpox-associated encephalitis was admitted to the ICU and transferred 12 h later to Infectious Disease Hospital.…”

Section: Kuwaitmentioning

confidence: 99%

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Varicella infection in the Middle East: Prevalence, complications, and vaccination

Al-Turab

Chehadeh

2018

J Res Med Sci

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Varicella (chickenpox) is the primary infection of varicella-zoster virus (VZV), it is a mild self-limiting infection, but it is also highly contagious and can cause severe complications among high-risk group of individuals. It is usually a childhood infection providing lifelong immunity, but adults without varicella history are also susceptible to infection. High-risk group of individuals is more likely to develop serious complications. Varicella vaccine was introduced to protect this group of individuals and to prevent epidemic spread of VZV infection in a community. Thus, it was added to the recommended vaccination schedules for children in most developed countries. This review aimed to outline varicella status, seroprevalence, complications, and vaccination in the Middle East region. Based on our findings, children were the most affected age group, but there are also adult cases due to high number of expatriates, especially in Gulf Cooperation Council countries. Central nervous system involvements and skin diseases followed by varicella pneumonia were the most varicella-associated complications. Varicella vaccine was introduced in most Middle East countries, either mandatory by the Ministries of Health or optional in the private clinics. Few numbers of studies have reported an obvious reduction in varicella prevalence, hospitalizations, and deaths in the Middle East following varicella vaccination. A basic database about varicella infection before the initiation and implementation of a vaccination policy is essential to determine the target group of individuals. As far as our knowledge, this is the first review about varicella infection in the Middle East.

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Section: Kuwaitmentioning

confidence: 99%

Section: Kuwaitmentioning

confidence: 99%

Varicella infection in the Middle East: Prevalence, complications, and vaccination

Al-Turab

Chehadeh

2018

J Res Med Sci

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“…She responded to prolonged anticoagulant therapy [18]. Another case reported in a 6-year-old boy with purpura fulminans was treated with fresh frozen plasma, anticoagulants, immunoglobulins and steroids [19]. A role of hyperbaric oxygen as an adjunctive therapy in the management of acute thrombotic purpura complicating varicella has been described.…”

Section: Discussionmentioning

confidence: 99%

Rare complications of chickenpox in children

Sharma

Jora

et al. 2015

J Pediatr Infect Dis

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Chickenpox, caused by varicella-zoster virus, is a common infection of childhood, especially in developing countries like India, where immunization coverage is low. Fifty percent of children are infected by 5 years of age and 90% by 12 years of age. Though the disease usually runs a benign, self limited course, yet in severe infections life threatening complications may develop. Deep vein thrombosis and spreading infective necrotizing fascitis are very rare complications of this disease. We report here two cases of surgical emergencies associated with varicella and review the literature.

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“…More than 90% of chickenpox cases occur in children < 10 years of age. The disease usually runs a benign course in immunocompetent children although complications such as purpura fulminans necessating skin grafting has been rarely reported 1 . Increased morbidity is seen in adults and in patients who are immunocompromised.…”

Section: Discussionmentioning

confidence: 99%

Bullous chickenpox: an unusual clinical variant of varicella

et al. 2008

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A 9-year-old previously healthy boy presented with a 3-d history of progressive mildly itchy lesions over the whole body associated with low grade fever. Lesions initially started over the abdomen and then spread to involve the extremities and face with sparing of the mucosa. Physical examination revealed a generalized rash consisting of vesicles on erythematous bases as well as large tense and flaccid bullae on the lower extremities (Figs 1 and 2). Two biopsies were taken, one from a vesicle and the other from a tense bulla, which also included part of the normal skin (Fig. 3). Both specimens revealed

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Varicella-Associated Purpura Fulminans: Chicken Pox Is Not Always Benign

Cited by 7 publications

References 21 publications

Varicella infection in the Middle East: Prevalence, complications, and vaccination

Varicella infection in the Middle East: Prevalence, complications, and vaccination

Rare complications of chickenpox in children

Bullous chickenpox: an unusual clinical variant of varicella

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