Varicella Followed by Glomerulonephritis

Pedersen, F. K.; Petersen, Eskild A.

doi:10.1111/j.1651-2227.1975.tb03943.x

Cited by 21 publications

(5 citation statements)

References 10 publications

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“…Corticosteroids are one of the mainstays of treatment for IgA vasculitis. According to literature review, varicella-zoster virus associated IgA vasculitis is a rare condition reported previously [3][4][5][6][7] . Varicella was considered as a stimulus that could trigger IgA vasculitis in most of these cases.…”

Section: Discussionmentioning

confidence: 99%

Severe Hemorrhage Secondary To IgA Vasculitis With Varicella Infection: A Case Report

Jiang¹,

Liao²,

Guo³

2021

Preprint

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IgA vasculitis (IgAV), formerly named as Henoch Schönlein Purpura, is an IgA-mediated systemic small vessel vasculitis with skin, gastrointestinal tract, joints, and kidneys involvement. It is the most common vasculitis in childhood. Varicella-zoster virus-associated IgA vasculitis has been reported previously in few cases. However, IgA vasculitis complicated by chickenpox rarely occurred severe hemorrhagic manifestation and had not yet been reported. Herein, we present a case of an eight-year-old girl who developed IgA vasculitis complicated by disseminated intravascular coagulation and multiple organ dysfunction syndrome, including severe acute pancreatitis and acute liver failure secondary to varicella-zoster virus infection and finally underwent blood purification including hemoperfusion, plasmapheresis, and continuous renal replacement therapy. Tumors and other diseases affecting coagulation and platelet function, such as systemic lupus erythematosus, ANCA-associated vasculitis, primary thrombocytopenia, and secondary thrombotic microangiopathies, have been excluded during her hospitalization. Varicella was considered to be the cause of the severe complications. A possible mechanism for the occurrence of severe complications is that chickenpox infection induces the production of heparin-like substances disturbing normal coagulation function, and finally occurs uncontrolled hemorrhage manifestation including gastrointestinal hemorrhage, uncontrolled bleeding at the catheter placement and injection site. She eventually was discharged after undergoing 37 days of treatment by antibiotics, antiviral drugs, protamine neutralizing heparin therapy and various blood products transfusion including platelets, red cells, fresh frozen plasma, cryoprecipitate, fibrinogen, and prothrombin complex transfusions. At the end of a month follow-up, the patient showed the purpuric rashes had nearly faded and had no sign of complication including the gastrointestinal tract, liver, and pancreas. Renal function tests and routine analysis of blood were normal. Hematuria(3+~4+) and proteinuria(1+~2+) can be seen in her urinalyses. At the 5th month follow-up, her renal function test and her urinalysis were normal, and her oral steroids were stopped completely. On this occasion, we should reduce the dose of heparin or no heparin in blood purification for IgA vasculitis complicated by chickenpox to reduce the incidence of severe bleeding or death.

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Section: Discussionmentioning

confidence: 99%

Severe Hemorrhage Secondary To IgA Vasculitis With Varicella Infection: A Case Report

Jiang¹,

Liao²,

Guo³

2021

Preprint

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“…Morphologically documented case reports have shown acute proliferative glomerulonephritis, in some patients with numerous crescents (11)(12)(13)(14)(15). Glomerulonephritis in varicella infection is not common.…”

Section: Discussionmentioning

confidence: 99%

“…Although rare, there have been reports on hepatitis complicating varicella infection even in immunocompetent adults (9,10). Glomerulonephritis in varicella-infected renal transplant patients has to our knowledge not been reported previously, whereas case histories of glomerulonephritis in association with varicella infection in the immunocompetent patients have been described (11)(12)(13)(14)(15)(16).…”

mentioning

confidence: 98%

Varicella Infection in a Renal Transplant Recipient Associated with Abdominal Pain, Hepatitis, and Glomerulonephritis

Os¹,

Strøm²,

Stenehjem³

et al. 2001

Scandinavian Journal of Urology and Nephrology

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A 36-year-old renal transplant patient developed 9 years after a successful transplantation a fatal secondary varicella infection. The disseminated varicella infection was associated with hepatitis with liver necrosis, disseminated intravascular coagulation and fibrinolysis and glomerulonephritis. To our knowledge this is the first description of glomerulonephritis associated with varicella infection in a renal transplanted patient. The autopsy showed morphologically a mesangial glomerulonephritis with minor proliferative activity and extensive deposits by electronmicroscopy, mainly in the mesangium. The ongoing immunosuppression may have modified the mesangial cell response to the deposition of immune complexes.

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“…Es importante reseñar otras infecciones no estreptocócicas que cursan con un cuadro clínico y anatomopatológico similar con la GNPS como la neumonía neumocócica 8 , estafilococias 8 -20 , salmonelosis 25 así como en diversas virasis: mononucleosis infecciosa 11 , varicela 18 , coxsackie 2 , echo 29 y parasitosis como la toxoplasmosis 6 .…”

Section: Etiologíaunclassified