Varicella Outbreaks in Army Recruits From Puerto Rico

Longfield, Jenice N.

doi:10.1001/archinte.1990.00390170032008

Cited by 75 publications

(10 citation statements)

References 21 publications

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“…Adults who develop varicella should receive routine treatment with acyclovir to reduce the duration and severity of the illness and the risk of complications. The higher levels of varicella susceptibility found among these Mexican-born adults working in the United States support earlier studies that have reported higher levels of susceptibility among adults from some tropical areas, compared with those from temperate climates [5][6][7][8][9]. In the United States, high rates of varicella-related hospitalization among Hispanic persons have previously been reported [22].…”

Section: Discussionsupporting

confidence: 81%

“…Before varicella vaccine was introduced in the United States in 1995, an estimated 4 million cases, 11,000 hospitalizations, and 100 deaths occurred annually as a result of varicella [2][3][4], with ∼90% of cases occurring among children aged р15 years. In tropical climates, VZV infection is less common in childhood, resulting in higher susceptibility among adults [5][6][7][8][9]. Infected adults are at higher risk for complications than are children [4,10]; in the United States, adults are 9-15 times more likely to be hospitalized for varicella and 25-30 times more likely to die from it than are children [3,4,11].…”

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confidence: 99%

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High Rate of Varicella Complications among Mexican‐Born Adults in Alabama

Danovaro-Holliday

Gordon²,

Jumaan

et al. 2004

CLIN INFECT DIS

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Section: Discussionsupporting

confidence: 81%

mentioning

confidence: 99%

High Rate of Varicella Complications among Mexican‐Born Adults in Alabama

Danovaro-Holliday

Gordon²,

Jumaan

et al. 2004

CLIN INFECT DIS

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“…No Brasil e na maioria dos outros países latinoamericanos existem somente dados empíricos sobre a epidemiologia da varicela, prevalência de anticorpos anti-VZV na população e sobre surtos da doença 15,16,22,23 . Esta escassez de dados, associada à disponibilidade de uma vacina efetiva, estimularam o início deste estudo soroepidemiológico, prospectivo, transversal e baseado na população.…”

Section: Discussionunclassified

Soroepidemiology of Varicella in Brazil - results of a prospective cross-sectional study

Clemens¹,

Azevedo²,

Fonseca³

et al. 1999

J Pediatr (Rio J)

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ResumoObjetivos: A varicela tem conseqüências mais graves em adolescentes e adultos. Recentes relatos da Europa e da Ásia mostram um número crescente de adolescentes e adultos jovens soronegativos. Como são poucos os dados sobre a prevalência de anti-VZV no Brasil e com o objetivo de definir estratégias para a imunização contra a varicela, realizamos um estudo de soroprevalência para o VZV (vírus varicela zoster) em diferentes partes do Brasil.Métodos: Este estudo soroepidemiológico, transversal e populacional foi realizado em quatro diferentes regiões do Brasil. A população estudada foi estratificada por sexo, idade e situação socioeconômica. Anticorpos Ig G, anti-VZV foram analisados pelo método ELISA.Resultados: Foram incluídos no estudo 3.879 indivíduos de 1 a 40 anos. A taxa de soropositividade do anti-VZV em todos os grupos etários e centros no Brasil foi de 85,4 %. Evidenciou-se uma forte correlação com a idade. Especialmente no Sudeste e Sul, a soroprevalência foi menor no grupo etário de 1-5 anos (44,5% e 57,8%, respectivamente). Na região Norte esta taxa foi de 88,9%. No geral, a infecção pelo VZV foi independente do nível socioeconômico, entretanto nos grupos etários jovens (1-10 anos) a soroprevalência foi significativamente menor nas classes alta/média, na maioria das regiões. A história clínica de varicela se correlacionou com a soropositividade anti-VZV, tendo um valor preditivo de 95,1%.Conclusões: Na pré-adolescência, uma proporção substancial da população brasileira é susceptível à varicela e uma parcela considerável de adolescentes e adultos jovens permanecem soronegativos e, conseqüentemente, em risco. AbstractObjectives: Varicella has more serious consequences in adolescents and adults. Recent reports from Europe and Asia show an increasing number of adolescents and young adults being seronegative. As there is only limited data on varicella zoster virus (VZV) seroprevalence in Brazil and to facilitate the strategy for varicella vaccination we conducted a VZV seroprevalence study in Brazil.Methods: This population-based, cross sectional seroepidemiology study was performed in 4 different regions of Brazil. The studied population was stratified according to gender, age and socioeconomic status. VZV IgG antibodies were analyzed by ELISA.Results: 3,879 subjects aged 1-40 years were included into the study. The overall anti-VZV seropositivity rate across all age groups and centers in Brazil was 85.4%. There was a strong age relationship. Especially in the South East and South seroprevalence was low in the age group 1-5 years (44.5% and 57.8%, respectively) while in the North the rate was 88.9%. Overall, Varicella infection was independent of the socioeconomic level, but in the youngest age groups (1-10 years) seroprevalence rates were significantly lower in the high/medium socioeconomic class for most regions. Clinical history of chickenpox correlates well with anti-VZV seropositivity with a predictive value of 95.1%Conclusions: In preadolescence a substantial proportion of the Brazilian populat...

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“…(A similar trend was also observed pre immunisation in the USA.) 3,4 However differing conclusions have been reached from other studies. 5e8 The seroepidemiological data will depend on the population being studied; with increasing numbers of persons originating from countries where varicella in adults is relatively more common (amongst immigrants and asylum seekers), the number of susceptible women of childbearing age will increase.…”

Section: Introductionmentioning

confidence: 91%