Varicella vaccination of health-care workers

Burgess, Margaret; Cossart, Yvonne E.; Wilkins, Tracy D.; Botham, S J; Fearns, Grace; Chitour, Kerim

doi:10.1016/s0264-410x(98)00260-6

Cited by 14 publications

(4 citation statements)

References 24 publications

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“…This study also focuses on the trends of VZV seen in India in three states with different clinical presentations thus making differential clinical diagnosis difficult and critical. The need for the universal use of personal protective equipment by healthcare providers along with Varicella vaccination to prevent the infection amongst the healthcare providers has been highlighted based on observations in the fatal case of Rajasthan state which resulted in secondary infections in 11 healthcare providers including doctors, nurses and paramedical staff (Burgess et al., 1999). During an outbreak situation, it becomes difficult to manage with the shortage of beds and available healthcare staff.…”

Section: Discussionmentioning

confidence: 99%

Clinico-epidemiological investigation on Varicella Zoster Virus indicates multiple clade circulation in Maharashtra state, India

Sahay

Yadav

Majumdar

et al. 2018

Heliyon

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BackgroundVaricella Zoster Virus (VZV) is consistently in circulation and shows an increase in disease burden during the spring season. Due to a wide range of clinical presentation from a vesicular rash to bleeding or neurological complications, it makes the clinical diagnosis difficult. The present study aims to understand whether the same strain of virus is responsible for the increase in the seasonal outbreaks occurring in different parts of the country with reference to the samples from Maharashtra, Rajasthan and Gujarat states of India.Materials and methodsThis study reports the clinico-epidemiological and laboratory findings of suspected Varicella cases. To understand the circulating clade few representative real-time Polymerase Chain Reaction (PCR) positive were analyzed by conventional PCR and partial Open Reading Frame (ORF) 22, partial ORF 38 and partial ORF 54 were sequenced to identify single nucleotide polymorphisms responsible for clade determination. Further partial glycoprotein B gene was sequenced, and a phylogenetic tree was generated.ResultsA total of 50 cases from Maharashtra (Mumbai district) and referred clinical samples of Rajasthan (Barmer district; n = 12) and Gujarat States (Gandhi Nagar, Surat districts; n = 17) were tested for the presence of VZV. Vesicular rash with fever was a common clinical presentation with 82% cases having contact history with VZV positive cases, suggesting higher secondary attack rate. The vesicular fluid of all 50 cases from Mumbai revealed the presence of VZV by real-time PCR. Urine, serum and throat swab samples showed positivity by real-time PCR. Healthcare provider's samples from Rajasthan showed 36.4% [4/11] positivity. Clinical samples from Gujarat had positivity of 41.2% [7/17].ConclusionsThis study analyses the clade based circulation of VZV in three states in India and suggests different clades circulating in Maharashtra state. Health education amongst the general population is suggested to reduce the secondary cases by early diagnosis, effective isolation policies and vaccination to reduce the burden of disease.

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Section: Discussionmentioning

confidence: 99%

Clinico-epidemiological investigation on Varicella Zoster Virus indicates multiple clade circulation in Maharashtra state, India

Sahay

Yadav

Majumdar

et al. 2018

Heliyon

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“…In adolescents and adults, eligibility for varicella vaccine should be based on both a negative history of previous varicella infection and negative serology 1 . This recommendation is supported by the finding that up to 60% of adolescents/adults with no history of varicella have IgG to varicella on conventional tests 17 . However, the receipt of varicella vaccine in previously immune persons has not been associated with any side‐effects 1…”

Section: Varicella Vaccinementioning

confidence: 97%

“…1 This recommendation is supported by the finding that up to 60% of adolescents/adults with no history of varicella have IgG to varicella on conventional tests. 17 However, the receipt of varicella vaccine in previously immune persons has not been associated with any side-effects. 1…”

Section: Adolescents Aged 14 Years and Older And Adultsmentioning

confidence: 99%

Varicella vaccination in Australia

Beutels

McIntyre

et al. 2005

J Paediatrics Child Health

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Varicella zoster virus (VZV) causes both chickenpox and herpes zoster and is responsible for a significant disease burden, including hospitalizations and deaths, in Australian children and adults. Varicella vaccine has been available in Australia for 5 years; however, from November 2005, it will be funded for use in all susceptible children at 18 months and 10-13 years of age under the National Immunisation Program. Experience with universal varicella vaccination of children in the USA over the last 10 years has shown that the vaccine is safe and highly effective in reducing varicella-related disease. This review summarizes the epidemiology of VZV-related disease in Australia, the use of varicella vaccine and the international experience with vaccine efficacy and safety. The potential impact of varicella vaccination on the incidence of herpes zoster is also discussed.

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“…48 Vaccine-mediated immunity is less robust than natural immunity and may decrease after 10 to 20 years. 49 Serologic Evidence of Immunity. As with MMR, commercially available EIAs are somewhat insensitive to varicella vaccineinduced antibodies.…”

Section: Varicella Vaccinementioning

confidence: 99%

Vaccines for Health Care Personnel

Swift

Behrman²

2019

Mayo Clinic Proceedings

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Medical Center Occupational Health (MCOH) programs must protect health care personnel (HCP) against the occupational risk of vaccine-preventable diseases. This thematic review outlines the rationale for the use of recommended vaccines in HCP; summarizes the available evidence regarding vaccine effectiveness, administration, and assessment of immunity; and provides guidance for MCOH programs navigating challenging situations.

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Varicella vaccination of health-care workers

Cited by 14 publications

References 24 publications

Clinico-epidemiological investigation on Varicella Zoster Virus indicates multiple clade circulation in Maharashtra state, India

Clinico-epidemiological investigation on Varicella Zoster Virus indicates multiple clade circulation in Maharashtra state, India

Varicella vaccination in Australia

Vaccines for Health Care Personnel

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