Varicella Zoster Meningitis in a Pregnant Woman with Acquired Immunodeficiency Syndrome

Jayakrishnan, Asha; Vrees, Roxanne; Anderson, Brenna L.

doi:10.1055/s-0028-1085625

Cited by 4 publications

(5 citation statements)

References 2 publications

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“…Herpes zoster, or the reactivation of dormant varicella zoster, in pregnancy is exceedingly rare, as antibodies prevent transplacental viral transmission. VZV meningitis has been reported in an HIV-positive pregnant woman, presenting as a painful vesicular rash in an L3 dermatome and subsequently developing meningitis symptoms of headache, fever, neck stiffness, and photophobia ( Jayakrishnan et al, 2008 ).…”

Section: Virusesmentioning

confidence: 99%

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Neurologic infections during pregnancy

Curcio

Shekhawat

Reynolds

et al. 2020

Handbook of Clinical Neurology

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Neurologic infections during pregnancy represent a significant cause of maternal and fetal morbidity and mortality. Immunologic alterations during pregnancy increase the susceptibility of the premature brain to damage. This chapter summarizes the epidemiology, pathophysiology, and clinical manifestations in the pregnant woman and the infant, and the diagnosis, treatment, and prevention of the major viral, parasitic, and bacterial infections known to affect pregnancy. These organisms include herpes virus, parvovirus, cytomegalovirus, varicella, rubella, Zika virus, toxoplasmosis, malaria, group B streptococcus, listeriosis, syphilis, and tuberculosis. There is an emphasis on the important differences in diagnosis, treatment, and fetal outcome between trimesters. An additional overview is provided on the spectrum of neurologic sequelae of an affected infant, which ranges from developmental delay to hydrocephalus and seizures.

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Section: Virusesmentioning

confidence: 99%

“…In the rare cases of VZV meningoencephalitis, acyclovir has been used as treatment, including its use in one immunocompromised pregnant woman ( Jayakrishnan et al, 2008 ).…”

Section: Virusesmentioning

confidence: 99%

Neurologic infections during pregnancy

Curcio

Shekhawat

Reynolds

et al. 2020

Handbook of Clinical Neurology

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“…Though VZ is a self limiting and mild infection, it can be severe in adults and in individuals with cellular immunodeficiency such as that occasioned by infection with the HIV virus [21]. These individuals are at much higher risk of pneumonia [22] and disseminated disease [23] with visceral involvement though none was observed in this study.…”

Section: Prevalence Of Viral Skin Infectionsmentioning

confidence: 67%

Viral Skin Infections in Adult Patients with HIV/AIDS in a Tropical Rural Practice in Nigeria

Salami

Echekwube

2015

ISRR

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Background:The skin, like all organs in the body is affected by several diseases in patients with HIV/AIDS. This is particularly so with viral skin disorders where impaired cellular immunity seems to be a common pathway of susceptibility. There are however few documented studies of these conditions in Nigeria and some other neighbouring west African countries. This study aims to identify these skin disorders in patients attending the adult outpatient clinic in a rural/suburban health centre in the southern part of Nigeria and collate the differences and similarities to other related studies. Methods/Design: This was done among HIV infected adult patients in the outpatient HIV clinic. It was a prospective observational study done in Irrua Specialist Teaching Hospital Irrua Edo State Nigeria. The study was done over a 12 months period. All patients with skin complaints were included in the study while those without were excluded. Results: Nine thousand, four hundred and sixty patients were seen during this period including new and old patients returning for follow up visits. Four hundred and ninety had different

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“…The prior reported case in pregnancy has been in a woman with AIDS. 4 Authors believe the overall number of reported cases in the past has been low due to a possible under diagnosis of the condition as it can present with variable and mild symptoms. This case also was diagnosed only after the PCR test was done on the CSF and clinically there were no suggestive symptoms.…”

Section: Discussionmentioning

confidence: 99%

Varicella meningitis in pregnancy: a clinical conundrum

Gholkar¹,

Verghese

2020

Int J Reprod Contracept Obstet Gynecol

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Authors present this experience of managing a case of Varicella meningitis in pregnancy in a patient presenting with headache in the third trimester. There was no history of dermatomal pain or rash. After intracranial hemorrhage and thrombosis were ruled out by imaging, a decision to perform a lumbar puncture was taken. The diagnosis was made following a PCR analysis on the cerebro-spinal fluid. Retrospective testing revealed immunity to varicella at booking, thus confirming reactivation of the infection. Treatment was done using intravenous acyclovir with complete recovery. It also created a clinical dilemma for the best possible monitoring plan for the fetus to rule out affection. A fetal medicine scan revealed no structural defects in the fetus. The subsequent pregnancy period was uneventful. A well grown normal baby was born at term. This case highlights the significance of considering a lumbar puncture in cases of intractable headache and also highlights the dilemma for fetal monitoring in such rare presentations.

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Varicella Zoster Meningitis in a Pregnant Woman with Acquired Immunodeficiency Syndrome

Cited by 4 publications

References 2 publications

Neurologic infections during pregnancy

Neurologic infections during pregnancy

Viral Skin Infections in Adult Patients with HIV/AIDS in a Tropical Rural Practice in Nigeria

Varicella meningitis in pregnancy: a clinical conundrum

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