Varicella Zoster Virus-Induced Complete Heart Block

Singhal, Ruchi; Jin, Phoebe; Nassereddin, Ali T; Lopez, Jonathan E; Keeley, Ellen C.

doi:10.1016/j.amjmed.2022.12.013

Cited by 3 publications

(4 citation statements)

References 5 publications

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“…Clinical evaluation may include a thorough physical examination to assess for symptoms of heart block, such as syncope, dizziness, palpitations, and shortness of breath. 7 The most common type of heart block seen in VZV-related heart block is the Mobitz type II or third-degree AV block, which is characterized by a complete blockage of electrical impulses between the atria and ventricles. Other ECG findings may include bundle branch block, premature ventricular contractions, and ventricular tachycardia.…”

Section: Discussionmentioning

confidence: 99%

“…Varicella-zoster virus (VZV)-related heart block is an infrequent but potentially serious complication of VZV infection. 7 The incidence of VZV-related heart block was estimated to be less than 1% of all VZV infections. However, the risk of developing this complication is increased in immunocompromised patients, such as those with HIV or undergoing chemotherapy, as well as in elderly individuals.…”

Section: Introductionmentioning

confidence: 99%

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Not Just a Rash: Herpes Zoster-induced Progressive Cardiac Block

Mahdi

Nassim

Mahdi

et al. 2023

kjm

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Not Just a Rash: Herpes Zoster-induced Progressive Cardiac Block

Mahdi

Nassim

Mahdi

et al. 2023

kjm

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“…VZV has been documented to necessitate permanent pacemaker placement due to complete heart block [ 111 , 112 , 113 ] and lead to second-degree atrioventricular block [ 114 ]. The development of a complete heart block is believed to result directly from the reactivation of the virus within the cardiac sympathetic/parasympathetic ganglia [ 111 ].…”

Section: Herpes Zoster-related Cardiovascular Diseasesmentioning

confidence: 99%

Herpes Zoster and Cardiovascular Disease: Exploring Associations and Preventive Measures through Vaccination

Yamaoka-Tojo,

Tojo

2024

Vaccines

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Herpes zoster, induced by the reactivation of the varicella-zoster virus (VZV), is a unilaterally distributed vesicular rash that can cause multiple complications. VZV not only causes neurological problems, including postherpetic neuralgia and ocular zoster, but also causes inflammatory vasculopathy and increases the incidence of hemorrhagic or ischemic complications. Therefore, understanding the association between the development of herpes zoster and the subsequent occurrence of acute stroke or cardiovascular diseases, including myocardial infarction and heart failure, is of great interest. Conversely, many risk factors are involved in the development of herpes zoster. Recently, it has become clear that aging, insufficient immune function, and diseases related to lifestyle habits (for example, stroke and cardiovascular disease), can trigger the onset of herpes zoster. Preventing the onset of herpes zoster, which substantially reduces quality of life, will lead to lower medical costs for countries and extend healthy life expectancy for general populations. Thus, because herpes zoster is a vaccine-preventable disease, active vaccination is recommended for high-risk groups. This review summarizes the association between herpes zoster and cardiovascular disease and vaccination against herpes zoster as a useful disease management and prevention measure for cardiovascular disease.

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“…The cause identified by most prominent study in this regard, published by Yang et al [ 255 ], identified the cause of cardiac concerns during VZV infection to be associated with the migration of viral particles from neural cells to vascular cells of the brain and heart, thus inducing an inflammatory response that could end up with occlusion in the bloodstream, ischemia, and infarction, or an autoimmune response with the formations of auto-IgM/IgG antibodies directed against lupus anticoagulant and cardiolipin molecules [ 256 ].…”

Section: Varicella Zoster Virus Cardiopathymentioning

confidence: 99%

Autoimmune Heart Disease: A Comprehensive Summary for Forensic Practice

et al. 2023

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Autoimmune heart disease is a non-random condition characterised by immune system-mediated aggression against cardiac tissue. Cardiac changes often exhibit nonspecific features and, if unrecognised, can result in fatal outcomes even among seemingly healthy young individuals. In the absence of reliable medical history, the primary challenge lies in differentiating between the various cardiopathies. Numerous immunohistochemical and genetic studies have endeavoured to characterise distinct types of cardiopathies, facilitating their differentiation during autopsy examinations. However, the presence of a standardised protocol that forensic pathologists can employ to guide their investigations would be beneficial. Hence, this summary aims to present the spectrum of autoimmune cardiopathies, including emerging insights such as SARS-CoV-2-induced cardiopathies, and proposes the utilisation of practical tools, such as blood markers, to aid forensic pathologists in their routine practice.

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Varicella Zoster Virus-Induced Complete Heart Block

Cited by 3 publications

References 5 publications

Not Just a Rash: Herpes Zoster-induced Progressive Cardiac Block

Not Just a Rash: Herpes Zoster-induced Progressive Cardiac Block

Herpes Zoster and Cardiovascular Disease: Exploring Associations and Preventive Measures through Vaccination

Autoimmune Heart Disease: A Comprehensive Summary for Forensic Practice

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