Varicella-zoster virus infection and autonomic dysfunction

Sakakibara, Ryuji; Sawai, Setsu; Ogata, Tsuyoshi

doi:10.1016/j.autneu.2022.103018

Cited by 6 publications

(5 citation statements)

References 69 publications

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“…Interestingly, a positive association was also found for bladder problems in the ME/CFS_S3 group but related to VZV antibody concentrations. Given that infections by VZV can also cause bladder dysfunction [ 60 ], we speculate that patients from this ME/CFS subgroup experienced a recent reactivation of the virus. Notwithstanding the recent observation of VZV reactivation after SARS-CoV-2 infections [ 61 ] or under stressful conditions [ 62 ], there is weak evidence for VZV reactivation in ME/CFS patients [ 26 , 63 ].…”

Section: Discussionmentioning

confidence: 99%

Association analysis between symptomology and herpesvirus IgG antibody concentrations in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and multiple sclerosis

Domingues¹,

Malato²,

Grabowska³

et al. 2023

Heliyon

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Section: Discussionmentioning

confidence: 99%

Association analysis between symptomology and herpesvirus IgG antibody concentrations in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and multiple sclerosis

Domingues¹,

Malato²,

Grabowska³

et al. 2023

Heliyon

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“…Therefore, the reactivation of VZV from both TSG and DRG, followed by the spread of the virus to the skin, could potentially result in virus-induced dysfunction of the autonomic nerves. 48 Previous studies have shown a close correlation between sympathetic nerves and the pathology of HN. 49 This can result in abnormal sensation and autonomic symptoms due to increased sympathetic outflow to the skin and collateral sprouting in the peripheral nerve fibers.…”

Section: Discussionmentioning

confidence: 96%

Analysis of the Risk Factors for Mechanical Allodynia in Herpetic Neuralgia: A Retrospective Cross-Sectional Study

Xu,

Gong,

Dong

et al. 2023

JPR

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Purpose Mechanical allodynia is reportedly common during herpetic neuralgia. The purpose of this study was to establish a risk prediction model to predict the individual risk of allodynia in herpetic neuralgia. Methods Three hundred and eighty-six patients with trunk herpetic neuralgia were divided into two regions, T2-5 and T6-11. The causality between allodynia and other factors was analyzed by a binary logistic regression model. Results 42.2% of subjects had allodynia, 137 suffered from dynamic allodynia, and 110 with dynamic allodynia experienced local sweating. The following 5 items as predictors determined this model: local sweating (Odd Ratio = 27.57, P<0.001), lesion location (Odd Ratio=2.46, P =0.017), pain intensity (Odd Ratio=1.38, P =0.020), pain duration (Odd Ratio=0.94, P =0.006), and local scars (Odd Ratio=0.07, P<0.001). The presence and development of allodynia are associated with local sweating. The positive proportion of the Iodine-starch test between the T2-5 (50.0%) with the T6-11 (23.7%) had a statistically significant difference ( χ 2 =5.36, P=0.021). 29.5% of patients at the T2-6 had obvious sweating, which was different from only sticky feelings at the T6-11 (70.5%, χ 2 =10.88, P=0.001). 19.2% of patients with residual scars and allodynia was significantly lower than 48.5% of patients without allodynia ( χ 2 =15.28, P<0.001). Conclusion This analysis suggests that local sweating is a concomitant symptom in dynamic allodynia, which imply the sympathetic nerves innervating the sweat glands of the skin were also involved during herpetic neuralgia. This may assist in the evaluation of dynamic allodynia and prove the role of sympathetic nerve intervention for herpetic neuralgia.

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“…In neurofibromatosis, greater autonomic flexibility predicted a better pain outcome, possibly as the disease does not affect the autonomic system but is more located near the skin. Contrary, in zoster infections, ECG‐derived measures could not predict pain, possibly because the zoster infections influence the functioning of the autonomic system (Sakakibara et al, 2022). Thus, even though these studies investigated different types of long‐term pain alterations, most conclude that a functioning autonomic system is needed and that a greater autonomic adaptivity is vital for preventing prolonged altered pain perception.…”

Section: Discussionmentioning

confidence: 99%

Prediction of pain using electrocardiographic‐derived autonomic measures: A systematic review

Wegeberg,

Sejersgaard‐Jacobsen,

Brock

et al. 2023

European Journal of Pain

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Background and ObjectivePain is a major clinical challenge, and understanding the pathophysiology is critical for optimal management. The autonomic nervous system reacts to pain stimuli, and autonomic dysfunction may predict pain sensation. The most used assessment of autonomic function is based on electrocardiographic measures, and the ability of such measures to predict pain was investigated.Databases and Data TreatmentEnglish articles indexed in PubMed and EMBASE were reviewed for eligibility and included when they reported electrocardiographic‐derived measures’ ability to predict pain response. The quality in prognostic studies (QUIPS) tool was used to assess the quality of the included articles.ResultsThe search revealed 15 publications, five on experimental pain, five on postoperative pain, and five on longitudinal clinical pain changes, investigating a total of 1069 patients. All studies used electrocardiographically derived parameters to predict pain assessed with pain thresholds using quantitative sensory testing or different scales. Across all study modalities, electrocardiographic measures were able to predict pain. Higher parasympathetic activity predicted decreased experimental, postoperative, and long‐term pain in most cases while changes in sympathetic activity did not consistently predict pain.ConclusionsMost studies demonstrated that parasympathetic activity could predict acute and chronic pain intensity. In the clinic, this may be used to identify which patients need more intensive care to prevent, for example postoperative pain and develop personalized chronic pain management.SignificancePain is a debilitating problem, and the ability to predict occurrence and severity would be a useful clinical tool. Basal autonomic tone has been suggested to influence pain perception. This systematic review investigated electrocardiographic‐derived autonomic tone and found that increased parasympathetic tone could predict pain reduction in different types of pain.

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Varicella-zoster virus infection and autonomic dysfunction

Cited by 6 publications

References 69 publications

Association analysis between symptomology and herpesvirus IgG antibody concentrations in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and multiple sclerosis

Association analysis between symptomology and herpesvirus IgG antibody concentrations in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and multiple sclerosis

Analysis of the Risk Factors for Mechanical Allodynia in Herpetic Neuralgia: A Retrospective Cross-Sectional Study

Prediction of pain using electrocardiographic‐derived autonomic measures: A systematic review

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