Varicocele

Afshar, Kouroush; Domes, Trustin

doi:10.5489/cuaj.5231

Cited by 7 publications

(4 citation statements)

References 15 publications

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“…Varicocele (VC) is the dilatation and tortuosity of the pampaniform plexus that drains the testicles (2). VC is a common type of male genital disease and can occur in men of any age, especially young people (3). It affects roughly 15% of the overall male population, up to 35% of men with primary infertility and up to 75% of men with secondary infertility.…”

Section: Introductionmentioning

confidence: 99%

Microsurgical and Varicocelectomy Compersion With and Without Testicular Delivery for Treatment of Varicocele: A Randomize Control Trial

Jan¹,

Khan²,

Tariq³

et al. 2022

AJHMN

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Purpose: Varicocele is a common type of male genital disease and can occur in men of any age, especially young people. Clinically venous enlargement or varicocele are found in about 15% of the general male population, up to 35% of men with primary fertility, and 75% of men with secondary fertility dysfunction. Varicoceles are known to be the most common cause of male infertility and can be corrected surgically, but the exact mechanism of sperm formation caused by varicocele-induced impairment remains controversial. Most men with varicocele are asymptomatic and infertile, with only 15% – 20% suffering from physical discomfort or other fertility-related problems. With therefore systematically evaluated the RCTs published together and summarized evidence evaluating the benefits of testicular delivery and ligation of gubernacular vein in microsurgical varicocelectomy. Methodology: Comprehensive electronic search using the keywords "microsurgical varicocelectomy", "gubernacular vein", "testicular delivery", "infertility" and "varicocele" was done in databases of Cochrane, PubMed, Embase, CINAHL and Web of Science databases. English language used to search databases. Some studies were taken from studies references. Result: Two studies reported grade II and III of varicoceles in patients that participated in the study. Overall sperm count in microsurgical resection with testicular delivery compared to microsurgical resection without testicular delivery, increased significantly (SMD = 0.23, 95% CI = 0.07-0.39, p =<.05), but sperm motility, sperm concentration and gradual increase have no difference in between the two microsurgical methods (p> 0.05). Conclusion: In conclusion, as a result of this systematic review and meta-analysis, compared with microsurgical varicocelectomy without testicular delivery, delivery of the testicles during microsurgical varicocelectomy to further to further ligate the gonadal veins leads to epidydemo orchitis and oedema, and longer surgery. In addition, testicular delivery may not improve parameters of sperm, serum testosterone, and incidence of varicose veins, wound inflammation and spontaneous pregnancy compared to non-delivered testicles. However, a higher level of research is needed to determine if testicular delivery is an important surgery in microsurgical venous ligation.

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Section: Introductionmentioning

confidence: 99%

Microsurgical and Varicocelectomy Compersion With and Without Testicular Delivery for Treatment of Varicocele: A Randomize Control Trial

Jan¹,

Khan²,

Tariq³

et al. 2022

AJHMN

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“…The pathophysiology of varicocele is not completely explained. The hypotheses assume that the causes may include hypoplasia of the developing male gonad in adolescence, congenital/acquired valve defects, venous obstruction, and anatomical variations [ 8 , 18 , 19 ]. Varicocele-related infertility is an effect of changes in testicular blood flow, including blood reflux and venous pressure, leading to scrotal hyperthermia, testicular hypoxia, endocrine disturbance, reflux and accumulation of toxic metabolites of adrenal or renal origin and testicular atrophy [ 7 , 8 , 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

The Negative Impact of Varicocele on Basic Semen Parameters, Sperm Nuclear DNA Dispersion and Oxidation-Reduction Potential in Semen

Gill

Kupś

Harasny

et al. 2021

IJERPH

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Since varicocele is so common in infertile men, this study intends to analyse the relationships between varicocele and conventional semen characteristics, sperm nuclear DNA dispersion and oxidation-reduction potential (ORP) in semen. Varicocele-positive and varicocele-negative infertile men (study groups) showed significantly lower standard sperm parameters and higher sperm DNA fragmentation (SDF) and ORP in semen than healthy volunteers and subjects with proven fertility (control groups). A lower proportion of low SDF levels (0–15% SDF) and higher incidence of high SDF levels (>30% SDF), as well as a higher prevalence of high ORP values (>1.37 mV/106 sperm/mL), were found in the study groups vs. the control groups. Moreover, infertile men had significantly lower odds ratios (ORs) for low SDF levels and significantly higher ORs for high SDF levels and high ORP. SDF and ORP were negatively correlated with sperm number, morphology, motility and vitality. Furthermore, a significant positive correlation was found between SDF and ORP. The obtained results suggest that disorders of spermatogenesis may occur in varicocele-related infertility. These abnormalities are manifested not only by reduced standard semen parameters but also by decreased sperm DNA integrity and simultaneously increased oxidative stress in semen.

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“…Varicocele (VC) is the dilation and tortuosity of the veins of the pampiniform plexus draining of the testicle (Zhang et al, 2017). VC is a kind of common male reproductive system disease, which could occur in males at any age, especially in young adults (Afshar & Domes, 2018). The impact of VC on semen parameters was firstly described at 1965 by Macleod, which caused 21%–41% of men with primary infertility and 75%–81% of men with secondary infertility, and it is a correctable cause of male infertility (Hou, Zhang, Zhang, Huo, & Li, 2015; Liao et al, 2019; Marmar, 2016; Pagani, Ohlander, & Niederberger, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…

Varicocele (VC) is the dilation and tortuosity of the veins of the pampiniform plexus draining of the testicle (Zhang et al, 2017).VC is a kind of common male reproductive system disease, which could occur in males at any age, especially in young adults (Afshar & Domes, 2018). The impact of VC on semen parameters was firstly described at 1965 by Macleod, which caused 21%-41% of men with primary infertility and 75%-81% of men with secondary infertility, and it is a correctable cause of male infertility (Hou, Zhang, Zhang,

…”

mentioning

confidence: 99%

Evaluation of clinical effects of microsurgical subinguinal varicocelectomy with and without testicular delivery

et al. 2020

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The aim of this study was to access whether microsurgical subinguinal varicocelectomy (MSV) with testicular delivery has a better therapeutic effect than MSV without testicular delivery, including semen quality, serum testosterone (T) level and International Index of Erectile Function (IIEF)‐5 score in infertility male patients with varicocele. In this prospective study, 181 patients were included and they chose the treatment by themselves. A total of 114 patients who received MSV without testicular delivery (TD) and 67 patients who received MSV with TD were followed‐up 6 months after the operation. Semen parameters, serum T level and IIEF‐5 scores were recorded before and 6 months after the operation. Results showed that MSV with or without TD could improve semen quality, serum T level and IIEF‐5 score. For semen quality 6 months after the operation, there was no significant difference between patients received MSV with or without TD. But in patients with varicocele of grade III, MSV without testicular delivery improved the sperm concentration and motility more. And patients received MSV without TD have a higher T level 6 months after the operation, especially in patients ≤27 years. MSV with TD is not superior to that without, but this should be verified in more samples and a better designed randomised controlled study in the future.

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Varicocele

Abstract: N/A

Cited by 7 publications

References 15 publications

Microsurgical and Varicocelectomy Compersion With and Without Testicular Delivery for Treatment of Varicocele: A Randomize Control Trial

Microsurgical and Varicocelectomy Compersion With and Without Testicular Delivery for Treatment of Varicocele: A Randomize Control Trial

The Negative Impact of Varicocele on Basic Semen Parameters, Sperm Nuclear DNA Dispersion and Oxidation-Reduction Potential in Semen

Evaluation of clinical effects of microsurgical subinguinal varicocelectomy with and without testicular delivery

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