Varicocele and reproductive function: epidemiology and infertility risk (the eamination of 3632 patients)

Bozhedomov, V A; Shomarufov, A B; Bozhedomova, G E; Okhobotov, D A; Камалов, Д.М.; Камалов, А А

doi:10.18565/urology.2021.3.122-128

Cited by 5 publications

(3 citation statements)

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“…In recent large-scale studies it was shown that men with varicocele had lower sperm concentration and motility than men without varicocele [4,5]. At the same time, the study conducted by Bozhedomov et al with total 3908 patients (3632 subfertile and 276 fertile) demonstrated almost the similar prevalence of varicocele between fertile and subfertile male groups (29,5% vs 27,2%, OR 1.13) [6].…”

Section: Main Bodymentioning

confidence: 95%

Varicocelectomy in Male Subfertility Treatment: ‘‘Updated’’ Indications for Surgery

B Shomarufov

2023

J Nephro & Endo Res

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We analyzed the recent literature data on varicocelectomy in treatment men from infertile couples. There are still a lot of unresolved issues that require clarification. It is still unclear the exact pathogenesis of testicular malfunction in some men with varicocele. Recent European and American urological guidelines recommend varicocele repair in men from infertile couples with “abnormal” semen parameters. Although, according to the 6th ed. of WHO laboratory manual for the examination and processing of human semen it is not clear the cut-off values between normal and abnormal semen parameters. Also, still unclear why approximately third part of patients do not experience any improvement after varicocele repair. According to the recent data analysis, total progressively motile sperm count (TMSC) and sperm concentration can be the significant predictors of semen improvement and pregnancy after varicocele repair. However, it should be remarked that the mean quality of existed data from low to moderate. All mentioned issues indicate the necessity of further large-scale multicenter randomized clinical trials.

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Section: Main Bodymentioning

confidence: 95%

Varicocelectomy in Male Subfertility Treatment: ‘‘Updated’’ Indications for Surgery

B Shomarufov

2023

J Nephro & Endo Res

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“…Varicocele is a common correctable cause of male subfertility. 1 , 2 Although the mechanisms of the influence of varicocele on male fertility are still being discussed, in general, the results of studies demonstrate that varicocele has a negative impact on spermatogenesis 3 , 4 and that varicocele correction improves sperm quality and increases real fertility. 5 – 7 Based on recent data, the European Association of Urology (EAU), the American Urological Association (AUA), and the American Society for Reproductive Medicine (ASRM) recommend surgery for infertile men with clinical varicocele and abnormal semen parameters.…”

Section: Introductionmentioning

confidence: 99%

Predictors of microsurgical varicocelectomy efficacy in male infertility treatment: critical assessment and systematization

Shomarufov

Bozhedomov

Сорокин

et al. 2022

Asian Journal of Andrology

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In this review, we tried to systematize all the evidence (from PubMed [MEDLINE], Scopus, Cochrane Library, EBSCO, Embase, and Google Scholar) from 1993 to 2021 on the predictors of microsurgical varicocelectomy efficacy in male infertility treatment. Regarding the outcomes of varicocele repair, we considered semen improvement and pregnancy and analyzed them separately. Based on the 2011 Oxford CEBM Levels of Evidence, we assigned a score to each trial that studied the role of the predictor. We systematized the studied predictors based on the total points, which were, in turn, calculated based on the number and quality of studies that confirmed or rejected the studied predictor as significant, into three levels of significance: predictors of high, moderate, and low clinical significance. Preoperative total motile sperm count (TMSC) coupled with sperm concentration can be a significant predictor of semen improvement and pregnancy after varicocelectomy. In addition, for semen improvement alone, scrotal Doppler ultrasound (DUS) parameters, sperm DNA fragmentation index (DFI), and bilateral varicocelectomy are reliable predictors of microsurgical varicocelectomy efficacy.

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“…Th e hematotesticular barrier performs a protective function for sperm that has undergone crossover. When the integrity of the hematotesticular barrier is violated due to injuries, surgical manipulations, or infectious diseases, immunoglobulins G, A, and M, as antisperm antibodies, bind to various antigens on the sperm surface [123][124][125][126]. To date, the best studied sperm antigens are as follows: PH-20 (sperm head antigen), SP-10 (sperm protein antigen), HAS-63 (human sperm antigen), fertilization antigen (FA-1 1), FA-2 (antigen fertilization 2), CS-1 (signal-dividing antigen), and SAGA-1 (spermaglutination antigen 1) [127,128].…”

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confidence: 99%

Urogenital Infection as a Factor of Development of Male Infertility

et al. 2023

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To date, according to statistics, in Ukraine there is an increase in the number of infertile marriages. Many studies have emphasized the male factor of infertility Often, male infertility is the result of a previous infectious disease or an acute genital inflammation. Microorganisms that infect sperm usually persist in the urinary tract as a monoinfection or form associations. Microorganisms in biofilms are able to acquire new, not yet studied, properties. Persistence of pathogens in the urogenital tract of men triggers several mechanisms of the pathological action on sperm, the first of which is the infectious factor, directly related to the adhesion and resulting in a complete or partial decrease in the mobility and deformation of sperm. On the other hand, the development of the inflammatory process as a trigger of an immune response directed simultaneously against the infectious agent and the affected sperm. The increase in the number of leukocytes at the site of inflammation activates the secretion of biological substances which also have a damaging effect on sperm. The generalized data allow drawing a conclusion about the significant influence of opportunistic and pathogenic microorganisms as part of associations or monoinfection on the morphofunctional state of spermatozoa.

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Varicocele and reproductive function: epidemiology and infertility risk (the eamination of 3632 patients)

Cited by 5 publications

References 0 publications

Varicocelectomy in Male Subfertility Treatment: ‘‘Updated’’ Indications for Surgery

Varicocelectomy in Male Subfertility Treatment: ‘‘Updated’’ Indications for Surgery

Predictors of microsurgical varicocelectomy efficacy in male infertility treatment: critical assessment and systematization

Urogenital Infection as a Factor of Development of Male Infertility

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