Varicocèle et infertilité masculine

Huyghe, E.; Methorst, C.; Faix, A.

doi:10.1016/j.purol.2023.09.003

Cited by 2 publications

(2 citation statements)

References 102 publications

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“…Infertility is defined as the inability to conceive after one year of frequent unprotected sexual intercourse. It is called primary if the couple has never had a child, secondary if the patient already has one or more children, but cannot conceive a new child [3,4].…”

Section: Discussionmentioning

confidence: 99%

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Untitled

2024

IJCMCR

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Varicocele is a common pathology that can affect different age groups and can cause male infertility. The origin of varicocele is multifactorial, the diagnosis is clinical coupled with scrotal Doppler ultrasound which remains the gold standard for the diagnosis of varicocele. However, its treatment is simple and often effective, hence the importance of knowing how to recognize and classify it. We represent a series of cases of 29 patients treated for varicocele in the urology department of the IBN ROCHD CASA-BLANCA University Hospital during the period from January 1, 2022 to December 31, 2022, having one or more abnormalities on the spermogram.

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Section: Discussionmentioning

confidence: 99%

“…Several mechanisms have been proposed to explain infertility but none are really proven. Suggested mechanisms include hypoxia and stasis, testicular venous hypertension, increased temperature, and increased catecholamines in the spermatic vein as well as increased oxidative stress [3][4][5].…”

Section: Discussionmentioning

confidence: 99%

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2024

IJCMCR

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Positive Effects of a Resveratrol-Based Nutraceutical in Association with Surgical Scleroembolization: A Pilot Retrospective Clinical Trial

Italiano,

Ceccarelli,

Italiano

et al. 2024

JCM

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Background: Varicocele still today represents a common cause of infertility in young men. The treatment strategy remains a surgical approach such as scleroembolization; however, the complete restoration of spermatic parameters afterward requires an average of six or more months to fully regain optimal seminal parameters. Recently, many studies have demonstrated the beneficial effects of Resveratrol in male fertility, given its potential anti-inflammatory, antiapoptotic, and mitochondrial effects. Therefore, Resveratrol-based nutraceuticals could be promising as an adjuvant to mitigate subfertility in patients with varicocele. Methods: In the present study, we retrospectively analyzed the effects of the administration of a Resveratrol-based nutraceutical after the scleroembolization procedure. The improvement of sperm quality in terms of number, motility, and morphology were considered to be the study’s main endpoints. A spreadsheet program was used for data analysis, and a p-value of <0.05 was considered significant. Results: We found a statistically significant improvement in the spermatic parameters (sperm count and total motility) and an increase in normal sperm after only 4 months of treatment. The supplementation with a Resveratrol-based nutraceutical associated with the surgical procedure showed encouraging results if compared to data from a control group and the results reported in the literature linked to scleroembolization practice alone. In fact, there was a clear improvement in the seminal parameters at 4 months. Conclusions: This suggests the positive impact of the Resveratrol-based nutraceutical in synergizing with scleroembolization in reducing the time needed to fully recover sperm function.

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Varicocèle et infertilité masculine

Cited by 2 publications

References 102 publications

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Positive Effects of a Resveratrol-Based Nutraceutical in Association with Surgical Scleroembolization: A Pilot Retrospective Clinical Trial

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