Varicose Veins in Women Cotton Workers. An Epidemiological Study in England and Egypt

Mekky, Siza; Schilling, R. S. F.; Walford, Joan

doi:10.1136/bmj.2.5657.591

Cited by 113 publications

(68 citation statements)

References 7 publications

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“…Mekky et al 25 encontraram o uso de vestuário constritivo como uma das principais causas de varizes entre trabalhadoras inglesas da indústria têxtil.…”

Section: Uso De Vestuário Constritivounclassified

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Doença venosa e sua relação com as condições de trabalho no setor de produção de refeições

Luz

Proença

2008

Rev. Nutr.

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A doença venosa crônica é um problema de saúde pública importante, podendo promover inaptidão para o trabalho, tendo também uma repercussão indireta sobre a qualidade da produção e conseqüente perda de eficiência operacional. Embora ainda não haja evidência da relação direta causa-efeito de doença venosa com o trabalho, existe consenso científico de que o trabalho pode agravar o desenvolvimento da mesma. O presente estudo relata os fatores que podem influenciar o aparecimento ou agravamento de doenças venosas de membros inferiores em operadores de Unidades Produtoras de Refeições, ressaltando a importância e a possibilidade de aprofundamento do tema, o que poderia evoluir para o estabelecimento de um protocolo de prevenção e tratamento de doenças venosas em função do posto de trabalho executado. Reflete-se sobre o início de um processo de identificação deste distúrbio como uma doença de caráter ocupacional, o que contribuiria, portanto, para a reformulação conceitual dos encargos decorrentes dessa atividade profissional.

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“…Mekky et al 25 encontraram o uso de vestuário constritivo como uma das principais causas de varizes entre trabalhadoras inglesas da indústria têxtil.…”

Section: Uso De Vestuário Constritivounclassified

“…A literatura aponta algumas relações observadas entre sobrepeso e obesidade e a prevalência de varizes em indivíduos trabalhadores de diversos setores, evidenciando que o peso corporal constitui fator de risco para o desenvolvimento de varizes 3,14,15,[25][26][27] .…”

Section: Sobrepeso E Obesidadeunclassified

Doença venosa e sua relação com as condições de trabalho no setor de produção de refeições

Luz

Proença

2008

Rev. Nutr.

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“…Pregnancy-associated increases in uterine size and body weight along with hemodynamic changes could contribute to increased venous pressure in the lower extremities and the development of VVs. Other environmental and behavioral factors such as prolonged standing (Mekky et al, 1969) and a sedentary lifestyle could increase the risk for CVD (Jawien, 2003;Lacroix et al, 2003).…”

Section: Chronic Venous Diseasementioning

confidence: 99%

Matrix Metalloproteinases as Regulators of Vein Structure and Function: Implications in Chronic Venous Disease

MacColl

Khalil

2015

J Pharmacol Exp Ther

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Lower-extremity veins have efficient wall structure and function and competent valves that permit upward movement of deoxygenated blood toward the heart against hydrostatic venous pressure. Matrix metalloproteinases (MMPs) play an important role in maintaining vein wall structure and function. MMPs are zinc-binding endopeptidases secreted as inactive pro-MMPs by fibroblasts, vascular smooth muscle (VSM), and leukocytes. ProMMPs are activated by various activators including other MMPs and proteinases. MMPs cause degradation of extracellular matrix (ECM) proteins such as collagen and elastin, and could have additional effects on the endothelium, as well as VSM cell migration, proliferation, Ca 21 signaling, and contraction. Increased lower-extremity hydrostatic venous pressure is thought to induce hypoxia-inducible factors and other MMP inducers/ activators such as extracellular matrix metalloproteinase inducer, prostanoids, chymase, and hormones, leading to increased MMP expression/activity, ECM degradation, VSM relaxation, and venous dilation. Leukocyte infiltration and inflammation of the vein wall cause further increases in MMPs, vein wall dilation, valve degradation, and different clinical stages of chronic venous disease (CVD), including varicose veins (VVs). VVs are characterized by ECM imbalance, incompetent valves, venous reflux, wall dilation, and tortuosity. VVs often show increased MMP levels, but may show no change or decreased levels, depending on the VV region (atrophic regions with little ECM versus hypertrophic regions with abundant ECM) and MMP form (inactive pro-MMP versus active MMP). Management of VVs includes compression stockings, venotonics, and surgical obliteration or removal. Because these approaches do not treat the causes of VVs, alternative methods are being developed. In addition to endogenous tissue inhibitors of MMPs, synthetic MMP inhibitors have been developed, and their effects in the treatment of VVs need to be examined.

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“…Varicous veins are present in nearly the 30% of the female and in nearly the 15% of the male adult [11][12][13][14][15][16][17]. Venous *Address correspondence to this author at the Via Fratelli Coda 67/5 A, 16166-Genoa, Italy; Tel: +39-010-3724909; E-mail: andrea.cariati@libero.it ulcers occur in nearly the 0.3% of adult population in Western countries [13,18].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Leg Lymphatic Function in Patients with Leg Acute Venous Thrombosis and in Patients with Leg Post-Thrombotic Syndrome

Cariati¹

2012

TOCVJ

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Lymphatic and venous systems work together to drain interstitial fluid and blood respectively. Data on lymphatic function in chronic venous insufficiency and in chronic venous ulcerations are discordant. Modification of lymphatic function in acute venous thrombosis have been never described. The aim of this study is to report the modifications of the function of the lymphatic system in acute venous thrombosis, chronic venous ulceration and post-thrombotic syndrome. Discussion: The compensatory function of lymphatic system in acute venous thrombosis is definitively demonstrated. The lymphatic drainage of the limb affected by chronic venous ulceration is reduced. After the healing of the ulceration the lymphatic flow of the limbs affected by post-thrombotic syndrome improves but it remains under the levels of normal subjects.

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Varicose Veins in Women Cotton Workers. An Epidemiological Study in England and Egypt

Cited by 113 publications

References 7 publications

Doença venosa e sua relação com as condições de trabalho no setor de produção de refeições

Doença venosa e sua relação com as condições de trabalho no setor de produção de refeições

Matrix Metalloproteinases as Regulators of Vein Structure and Function: Implications in Chronic Venous Disease

Investigation of the Leg Lymphatic Function in Patients with Leg Acute Venous Thrombosis and in Patients with Leg Post-Thrombotic Syndrome

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