VARIDT 3.0: the phenotypic and regulatory variability of drug transporter

Abstract

The phenotypic and regulatory variability of drug transporter (DT) are vital for the understanding of drug responses, drug-drug interactions, multidrug resistances, and so on. The ADME property of a drug is collectively determined by multiple types of variability, such as: microbiota influence (MBI), transcriptional regulation (TSR), epigenetics regulation (EGR), exogenous modulation (EGM) and post-translational modification (PTM). However, no database has yet been available to comprehensively describe these valuable variabilities of DTs. In this study, a major update of VARIDT was therefore conducted, which gave 2072 MBIs, 10 610 TSRs, 46 748 EGRs, 12 209 EGMs and 10 255 PTMs. These variability data were closely related to the transportation of 585 approved and 301 clinical trial drugs for treating 572 diseases. Moreover, the majority of the DTs in this database were found with multiple variabilities, which allowed a collective consideration in determining the ADME properties of a drug. All in all, VARIDT 3.0 is expected to be a popular data repository that could become an essential complement to existing pharmaceutical databases, and is freely accessible without any login requirement at: https://idrblab.org/varidt/.

CyclicPepedia: a knowledge base of natural and synthetic cyclic peptides

“…Furthermore, the upcoming version of CyclicPepedia will predominantly focus on the data regarding cyclic peptide targets and their pharmacology properties. Pharmaceutical databases such as the Therapeutic Target Database [ 47 ], VARIDT [ 48 ], INTEDE [ 49 ], Comparative Toxicogenomics Database [ 50 ], TheMarker [ 51 ], and DrugMAP [ 52 ] will be explored for molecular interactions of cyclic peptides. Simultaneously, efforts will be made to enhance data quality and accuracy control, preventing the inclusion of duplicate or erroneous data.…”