Various Anti-Motion Sickness Drugs and Core Body Temperature Changes

Cheung, Bob; Nakashima, Ann; Hofer, Kevin

doi:10.3357/asem.2903.2011

Cited by 31 publications

(31 citation statements)

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“…This finding was confirmed in the musk shrew, where tail vasodilation preceded the first vomiting episode, when animals likely experienced nausea. Our observations mirror thermoregulatory changes reported in humans during nausea [12-15]. Together, they form the basis for a new concept – that disturbances in thermoregulation is a core element in the pathophysiology of nausea.…”

Section: Discussionsupporting

confidence: 83%

“…Secondly, it is now documented that in humans experiencing nausea, subjective perception of the ambient temperature as well as subjective preference for it are altered [13]. Lastly, as it was earlier found in humans [12, 14, 15], and as we now report in two different mammalian species, pro-emetic stimuli appear to suppress cold defence, by causing cutaneous vasodilatation leading to heat dissipation and fall in the core body temperature.…”

Section: Discussionsupporting

confidence: 69%

“…It is less known, but well documented that in humans nausea is also associated with profound disturbances in thermoregulation, including falls in the core body temperature, modified perception of the ambient temperature and preference for cooler environment [12-15]. It is currently unknown whether pro-emetic stimulation elicits similar disturbances in experimental animals, and we have designed our experiments to elucidate this question.…”

Section: Introductionmentioning

confidence: 99%

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Thermoregulatory correlates of nausea in rats and musk shrews

Ngampramuan

Cerri²,

Vecchio³

et al. 2014

Oncotarget

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Nausea is a prominent symptom and major cause of complaint for patients receiving anticancer chemo- or radiation therapy. The arsenal of anti-nausea drugs is limited, and their efficacy is questionable. Currently, the development of new compounds with anti-nausea activity is hampered by the lack of physiological correlates of nausea. Physiological correlates are needed because common laboratory rodents lack the vomiting reflex. Furthermore, nausea does not always lead to vomiting. Here, we report the results of studies conducted in four research centers to investigate whether nausea is associated with any specific thermoregulatory symptoms. Two species were studied: the laboratory rat, which has no vomiting reflex, and the house musk shrew (Suncus murinus), which does have a vomiting reflex. In rats, motion sickness was induced by rotating them in their individual cages in the horizontal plane (0.75 Hz, 40 min) and confirmed by reduced food consumption at the onset of dark (active) phase. In 100% of rats tested at three centers, post-rotational sickness was associated with marked (~1.5°C) hypothermia, which was associated with a short-lasting tail-skin vasodilation (skin temperature increased by ~4°C). Pretreatment with ondansetron, a serotonin 5-HT3 receptor antagonist, which is used to treat nausea in patients in chemo- or radiation therapy, attenuated hypothermia by ~30%. In shrews, motion sickness was induced by a cyclical back-and-forth motion (4 cm, 1 Hz, 15 min) and confirmed by the presence of retching and vomiting. In this model, sickness was also accompanied by marked hypothermia (~2°C). Like in rats, the hypothermic response was preceded by transient tail-skin vasodilation. In conclusion, motion sickness is accompanied by hypothermia that involves both autonomic and thermoeffector mechanisms: tail-skin vasodilation and possibly reduction of the interscapular brown adipose tissue activity. These thermoregulatory symptoms may serve as physiological correlates of nausea.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 69%

Section: Introductionmentioning

confidence: 99%

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Thermoregulatory correlates of nausea in rats and musk shrews

Ngampramuan

Cerri²,

Vecchio³

et al. 2014

Oncotarget

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“…The most evident of these responses are cold-sweating (Cheung et al, 2011; Hemingway, 1944; Nobel et al, 2012; Sclocco et al, 2015), changes in cutaneous thermoregulatory vascular tone (Nalivaiko et al, 2015), and pallor (Cassano et al, 1989; Kolev et al, 1997). Changes in skin blood flow that result in pallor are not accompanied by alterations in blood pressure (Sunahara et al, 1987; Sunahara et al, 1964), showing that they are not due to a global increase in sympathetic nervous system activity.…”

Section: Prodromal Physiological Changes: Potential Physiological mentioning

confidence: 99%

“…Money divided the physiological events associated with vomiting into two categories: stomach-emptying responses and stress responses (Money, 1970; Money et al, 1996). The latter term has mainly been used to describe responses such as cold-sweating (Cheung et al, 2011; Hemingway, 1944; Nobel et al, 2012; Sclocco et al, 2015) and pallor (Cassano et al, 1989; Kolev et al, 1997) that often occur following exposure to emetic stimuli, which are mediated through the sympathetic nervous system (Hammam et al, 2012). However, other physiological changes may be associated with the pre-emetic stress response, including alterations in heart rate variability (Doweck et al, 1997; Kim et al, 2011; Kim et al, 2005) and a release of vasopressin from the posterior pituitary (Fisher et al, 1982; Robertson, 1976; Rowe et al, 1979; Sorensen et al, 1985).…”

Section: Introductionmentioning

confidence: 99%

What is nausea? A historical analysis of changing views

Balaban

Yates

2017

Autonomic Neuroscience

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The connotation of “nausea” has changed across several millennia. The medical term ‘nausea’ is derived from the classical Greek terms ναυτια and ναυσια, which designated the signs and symptoms of seasickness. In classical texts, nausea referred to a wide range of perceptions and actions, including lethargy and disengagement, headache (migraine), and anorexia, with an awareness that vomiting was imminent only when the condition was severe. However, some recent articles have limited the definition to the sensations that immediately precede emesis. Defining nausea is complicated by the fact that it has many triggers, and can build-up slowly or rapidly, such that the prodromal signs and symptoms can vary. In particular, disengagement responses referred to as the “sopite syndrome” are typically present only when emetic stimuli are moderately provocative, and do not quickly culminate in vomiting or disengagement from the triggering event. This review considers how the definition of “nausea” has evolved over time, and summarizes the physiological changes that occur prior to vomiting that may be indicative of nausea. Also described are differences in the perception of nausea, as well as the accompanying physiological responses, that occur with varying stimuli. This information is synthesized to provide an operational definition of nausea.

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