Various Clinical Types of Q-fever Disease

Watanabe, Akira

doi:10.2169/internalmedicine.43.1

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…Chronic Q fever often presents as endocarditis (14) and/or hepatitis and has been diagnosed occasionally in osteomyelitis cases (36,41). An association has also been made between a chronic fatiguelike syndrome and Q fever (27,40,58,60).…”

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confidence: 98%

Clinical and Pathologic Changes in a Guinea Pig Aerosol Challenge Model of Acute Q Fever

et al. 2006

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Acute Q fever is a zoonotic disease caused by the obligate intracellular bacterium Coxiella burnetii and can manifest as a flu-like illness, pneumonia, or hepatitis. A need exists in Q fever research for animal models mimicking both the typical route of infection (inhalation) and the clinical illness seen in human cases of Q fever. A guinea pig aerosol challenge model was developed using C. burnetii Nine Mile phase I (RSA 493), administered using a specialized chamber designed to deliver droplet nuclei directly to the alveolar spaces. Guinea pigs were given 10 1 to 10 6 organisms and evaluated for 28 days postinfection. Clinical signs included fever, weight loss, respiratory difficulty, and death, with the degree and duration of response corresponding to the dose of organism delivered. Histopathologic evaluation of the lungs of animals infected with a high dose showed coalescing panleukocytic bronchointerstitial pneumonia at 7 days postinfection that resolved to multifocal lymphohistiocytic interstitial pneumonia by 28 days. Guinea pigs receiving a killed whole-cell vaccine prior to challenge with the highest dose of C. burnetii were protected against lethal infection and did not develop fever. Clinical signs and pathological changes noted for these guinea pigs were comparable to those seen in human acute Q fever, making this an accurate and valuable animal model of human disease.

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Clinical and Pathologic Changes in a Guinea Pig Aerosol Challenge Model of Acute Q Fever

et al. 2006

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Marine Chemosynthetic Symbioses

SpringerReference

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Outbreak of Query Fever among Argentinean Special Police Unit Officers during a United Nations Mission in Prizren, South Kosovo

Faas¹,

Engeler

Zimmermann

et al. 2007

Military Medicine

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After an outbreak of Query fever (Q fever) in an Argentinean special police unit, 115 officers were investigated to evaluate the risk of infection with Coxiella burnetii after having been exposed to contaminated dust originating from a nearby barn harboring infected sheep. All officers were serologically tested and the medical history of potential risk factors was performed. The percentage of officers showing acute Q-fever seroconversion was found to be 51.3%. Forty-two individuals showed clinical symptoms, among them, 28 patients underwent medical care. No relevant risk factor was found. In areas of an unknown epidemiological situation, patients with unclear respiratory infections should be serologically tested for C. burnetii to offer the correct treatment and avoid possible chronic cases. Attention has to be drawn to choosing the site of a camp so as to protect troops from possible infectious disease. During a U.N. mission in Kosovo, we observed a Q-fever outbreak among the Argentinean special police unit. Our investigation was initiated to evaluate the incidence of C. burnetii infection and Q-fever manifestations in an entire population sharing the same exposure risk and to develop suitable measures to interrupt transmission.

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Various Clinical Types of Q-fever Disease

Cited by 3 publications

References 4 publications

Clinical and Pathologic Changes in a Guinea Pig Aerosol Challenge Model of Acute Q Fever

Clinical and Pathologic Changes in a Guinea Pig Aerosol Challenge Model of Acute Q Fever

Marine Chemosynthetic Symbioses

Outbreak of Query Fever among Argentinean Special Police Unit Officers during a United Nations Mission in Prizren, South Kosovo

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