2023
DOI: 10.1111/cts.13629
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Various effects of repeated rifampin dosing on coproporphyrin levels in humans

Jonny Kinzi,
Markus Grube,
Karin Brecht
et al.

Abstract: In recent years, the identification of endogenous substrates as biomarkers became an uprising topic. Particularly coproporphyrins (CPs), byproducts of heme biosynthesis, are intensely investigated as biomarkers for predicting interactions with the organic anion transporting polypeptide (OATP) 1B transporters. In the context of drug‐drug interactions, several preclinical and clinical studies assessed the effect of the OATP1B‐index inhibitor rifampin on CPI levels. However, rifampin is not only a “perpetrator” d… Show more

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