Various Glaucomatous Optic Nerve Appearances

Nicolela, Marcelo T.; Walman, Brenda E.; Buckley, Anne; Drance, Stephen M.

doi:10.1016/s0161-6420(96)30448-x

Cited by 84 publications

(84 citation statements)

References 37 publications

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“…Previous studies showed that patients with POAG tend to have lower blood flow velocities, particularly the end-diastolic velocity and higher resistivity indices in their extraocular vessels compared with normal subjects [7, 8, 9, 20, 21, 22, 23]. In our study, we confirmed previous findings of lower blood flow velocities in the retrobulbar vessels of eyes with POAG.…”

Section: Discussionsupporting

confidence: 92%

“…In our study, we confirmed previous findings of lower blood flow velocities in the retrobulbar vessels of eyes with POAG. The alterations in orbital blood flow and circulation represented a risk factor for POAG; reduced blood flow velocities in the extraocular vessels may contribute to glaucomatous damage [20, 21, 24, 25]. …”

Section: Discussionmentioning

confidence: 99%

“…Decreased blood supply to the optic nerve head seems to have an important role in the development and progression of several forms of glaucoma [20, 21, 22]. It is not yet certain whether these retrobulbar blood flow parameters are altered in PXG.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Blood Flow Velocities of the Extraocular Vessels in Patients with Pseudoexfoliation or Primary Open-Angle Glaucoma

et al. 2001

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Purpose: To evaluate orbital blood flow velocities in patients with pseudoexfoliation glaucoma (PXG) or primary open-angle glaucoma (POAG). Methods: Blood flow velocities in the ophthalmic, central retinal, and posterior ciliary arteries were evaluated by color Doppler imaging in 26 patients with PXG, 28 patients with POAG and 30 age-matched normal control subjects. The results were compared. Results: Compared to the control subjects, patients with PXG showed statistically significant decreases in the mean peak systolic and end-diastolic velocities and increased mean resistive indices in all vessels except for the ophthalmic artery mean peak systolic velocity (p < 0.05). Patients with POAG, when compared to the control subjects, showed statistically significant decreases in the mean end-diastolic velocities and increased mean resistive indices in all vessels measured (p < 0.05). No statistically significant differences were found in the mean blood flow parameters between POAG and PXG. Conclusion: Blood flow velocities of the retrobulbar vessels are decreased in patients with PXG. Reduced blood flow velocities may be secondary as well as contributory to exfoliative glaucomatous damage. Although there was no significant difference in the mean blood flow parameters between POAG and PXG, alterations of retrobulbar vessels might be associated with different pathogenic mechanisms of PXG.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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Comparison of Blood Flow Velocities of the Extraocular Vessels in Patients with Pseudoexfoliation or Primary Open-Angle Glaucoma

et al. 2001

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“…For the diagnosis of the focal type of normal-pressure glaucoma [12,14,25,31,32], the maximal intraocular pressure readings had to be equal to or less than 21 mmHg in at least two 24-h pressure profiles containing measurements at 5 p.m., 9 p.m., midnight, 7 a.m. and noon. Other reasons for optic nerve atrophy had been ruled out by additional medical and neuroradiologic examinations.…”

Section: Methodsmentioning

confidence: 99%

“…The highly myopic type of primary open-angle glaucoma included all eyes with a myopic refractive error of more than ±8 diopters. Selection criteria for the group with the age-related atrophic type of primary open-angle glaucoma [13,16,25,31] were area of the Beta zone of the parapapillary atrophy [18] greater than 0.33 mm 2 (the median beta zone area in the total primary open-angle glaucoma group) and age greater than 60 years.…”

Section: Methodsmentioning

confidence: 99%

Prevalence of diabetes mellitus and arterial hypertension in primary and secondary open-angle glaucomas

Jonas

Gründler

1998

Graefe's Arch Clin Exp Ophthalmol

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Short-Wavelength Sensitivity Deficits in Patients With Migraine

McKendrick

Cioffi²,

Johnson³

2002

Arch Ophthalmol

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To examine short-wavelength sensitivity in patients with migraine using short-wavelength automated perimetry (SWAP) and Stiles 2-color increment threshold procedures. Methods: Twenty-five subjects with migraine with (n=11) and without (n = 14) aura and 20 age-matched headache-free subjects underwent testing. All subjects underwent standard automated perimetry (SAP) and SWAP (using a Humphrey field analyzer; 24-2 presentation pattern). In 2 migraine patients (one with and another without aura), the 2-color increment threshold procedure was used to determine whether sensitivity losses were specific to short-wavelength sensitivity pathways or a generalized loss to multiple pathways. Results: No statistically significant differences between migraine patients and controls were found for mean deviation (MD) or pattern-standard deviation (PSD) for SAP. However, for SWAP, MD and PSD were worse for the migraine group (P = .04). Twelve migraine patients had more than 4 locations with sensitivity worse than the 5% probability level (reference value). Increment threshold determinations in the 2 selected migraine patients indicated a selectively greater loss for short-wavelength sensitivity mechanisms. Conclusions: Approximately 50% of subjects with migraine (with or without aura) demonstrate SWAP sensitivity losses, at times between migraine events. These findings, in conjunction with previous results for SAP and flicker perimetry, suggest that migraine patients should be excluded from normative databases of visual function, and warrant further investigations of the relationship between migraine and glaucoma.

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Various Glaucomatous Optic Nerve Appearances

Cited by 84 publications

References 37 publications

Comparison of Blood Flow Velocities of the Extraocular Vessels in Patients with Pseudoexfoliation or Primary Open-Angle Glaucoma

Comparison of Blood Flow Velocities of the Extraocular Vessels in Patients with Pseudoexfoliation or Primary Open-Angle Glaucoma

Prevalence of diabetes mellitus and arterial hypertension in primary and secondary open-angle glaucomas

Short-Wavelength Sensitivity Deficits in Patients With Migraine

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