Various presentations of breast tuberculosis and tuberculous lymphadenopathy: A case series of surgical rarity

Sultan, Mohamed Arif Hameed; Hayati, Firdaus; Azizan, Nornazirah; Lee, Chang Haur; Sharif, Siti Zubaidah

doi:10.5222/mmj.2017.033

Cited by 3 publications

(6 citation statements)

References 9 publications

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“…All cases of SPPTB patients registered in the Sistem Maklumat Tibi (MyTB) database in Kota Kinabalu District between 2013 and 2018 were evaluated for inclusion. Kota Kinabalu has an estimated population of 500,000 with a population density of 613 persons per km 2 . An estimated TB incidence of 104 per 100,000 population in 2018 put Kota Kinabalu District above the national incidence rate of 92 per 100,000 population.…”

Section: Study Settingmentioning

confidence: 99%

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Predictors of delayed sputum smear conversion among pulmonary tuberculosis patients in Kota Kinabalu, Malaysia

et al. 2021

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Smear-positive pulmonary tuberculosis (SPPTB) is the major contributor to the spread of tuberculosis (TB) infection, and it creates high morbidity and mortality worldwide. The objective of this study was to determine the predictors of delayed sputum smear conversion at the end of the intensive phase of TB treatment in Kota Kinabalu, Malaysia.This retrospective study was conducted utilising data of SPPTB patients treated in 5 TB treatment centres located in Kota Kinabalu, Malaysia from 2013 to 2018. Pulmonary TB (PTB) patients included in the study were those who had at least completed the intensive phase of anti-TB treatment with sputum smear results at the end of the 2nd month of treatment. The factors associated with delayed sputum smear conversion were analyzed using multiple logistic regression analysis. Predictors of sputum smear conversion at the end of intensive phase were evaluated.A total of 2641 patients from the 2013 to 2018 periods were included in this study. One hundred eighty nine (7.2%) patients were identified as having delayed sputum smear conversion at the end of the intensive phase treatment. Factors of moderate (advanced odd ratio [aOR]: 1.7) and advanced (aOR: 2.7) chest X-ray findings at diagnosis, age range of >60 (aOR: 2.1), year of enrolment 2016 (aOR: 2.8), 2017 (aOR: 3.9), and 2018 (aOR: 2.8), smokers (aOR: 1.5), no directly observed treatment short-course (DOTS) supervisor (aOR: 6.9), non-Malaysian citizens (aOR: 1.5), and suburban home locations (aOR: 1.6) were associated with delayed sputum smear conversion at the end of the intensive phase of the treatment.To improve sputum smear conversion success rate, the early detection of PTB cases has to be fine-tuned so as to reduce late or severe case presentation during diagnosis. Efforts must also be in place to encourage PTB patients to quit smoking. The percentage of patients assigned with DOTS supervisors should be increased while at the same time ensuring that vulnerable groups such as those residing in suburban localities, the elderly and migrant TB patients are provided with proper follow-up treatment and management. Abbreviations: 95% CI = 95% confidence interval, AFB = acid fast bacilli, aOR = advanced odd ratio, DOTS = directly observed treatment short-course, EPTB = extrapulmonary tuberculosis, Mtb = Mycobacterium tuberculosis, PTB = pulmonary tuberculosis, SPPTB = smear-positive pulmonary tuberculosis, TB = tuberculosis, TBTC = tuberculosis treatment centres.

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Section: Study Settingmentioning

confidence: 99%

“…[1] In Malaysia, TB does not only cause morbidity on the pulmonary tuberculosis (PTB), but also on the extrapulmonary type. [2][3][4] The sputum smear test is widely used to diagnose PTB. PTB treatment targets include sputum smear conversion at the end of the intensive phase of anti-TB treatment.…”

Section: Introductionmentioning

confidence: 99%

Predictors of delayed sputum smear conversion among pulmonary tuberculosis patients in Kota Kinabalu, Malaysia

et al. 2021

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“…TB is deemed endemic in Malaysia, with 29,000 new cases annually and an incidence rate of 92 cases per 100,000 population in 2018 6 . From this, there are a minority of cases that involved extrapulmonary TB, including gastrointestinal TB 7–9 . Hence, this report presents a rare case of a colo‐appendico‐duodenal fistula, which to the extent of the authors' knowledge, is the first case reported in our region.…”

Section: Introductionmentioning

confidence: 71%

Colo‐appendico‐duodenal fistula: Rare presentation of extrapulmonary tuberculosis

Gan

Sibin

Payus

et al. 2021

Clinical Case Reports

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“…Tuberculosis is endemic in Asia especially in Malaysia with 11% of the cases of extrapulmonary TB [7]. TB liver is reported to exist in 50-80% of patients who are dying of pulmonary TB [8].…”

Section: Discussionmentioning

confidence: 99%

“…A combination of drugs may be given as part of a 9 to a 12month regimen consisting of 4 first-line drugs (rifampicin, isoniazid, pyrazinamide, and ethambutol) [10]. They are given in 2 phases namely intensive phase (first 2 months) and maintenance phase (next 3 month and beyond) [7]. In order to avoid non-compliance towards ATT, the initiation of fixed dosage such as Akurit-4 and directly observed therapy short-course has improved its delivery.…”

Section: Discussionmentioning

confidence: 99%

Incidental hepatic tuberculosis during planned resection of locally advanced ampullary carcinoma: a case report

et al. 2020

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Background: Tuberculosis (TB) is classified according to the site of disease as pulmonary or extrapulmonary. Extrapulmonary TB is less common than its counterpart in which it can be found anywhere in the body including the liver. Similar to ampullary carcinoma, TB liver can manifest with jaundice and deranged liver function tests, particularly in the obstructed biliary systems. Case presentation: A 43-year-old gentleman with locally advanced ampullary carcinoma was noticed to have multiple suspicious liver nodules intraoperatively during curative ampulla resection. The surgery was then abandoned after a biopsy. The histology was consistent with chronic granulomatous inflammation. He was then subjected to a Whipple pancreaticoduodenectomy procedure after initiation of anti-tubercular treatment. He recovered well with no evidence of tumour recurrence and worsening TB. Conclusions: A high index of suspicion and quick decision making can help to diagnose a possible extrapulmonary TB masquerading as a malignant disease in a patient with curative intention of ampullary carcinoma.

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Various presentations of breast tuberculosis and tuberculous lymphadenopathy: A case series of surgical rarity

Cited by 3 publications

References 9 publications

Predictors of delayed sputum smear conversion among pulmonary tuberculosis patients in Kota Kinabalu, Malaysia

Predictors of delayed sputum smear conversion among pulmonary tuberculosis patients in Kota Kinabalu, Malaysia

Colo‐appendico‐duodenal fistula: Rare presentation of extrapulmonary tuberculosis

Incidental hepatic tuberculosis during planned resection of locally advanced ampullary carcinoma: a case report

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