Various roles of astrocytes during recovery from repeated exposure to different doses of lipopolysaccharide

Bian, Yanqing; Zhao, Xiaowen; Li, Menghu; Zeng, Shaohua; Zhao, Bin

doi:10.1016/j.bbr.2013.07.028

Cited by 25 publications

(14 citation statements)

References 36 publications

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“…While post-septic encephalopathy in humans is characterized by both cognitive and affective impairment (Ziaja, 2013), in our study we found that post-septic mice had altered affective behaviours only, with cognitive performance remaining intact in the domains examined. This is in contrast to previous research which has found impaired reference and working memory in the radial arm maze following LPS-induced sepsis (Weberpals et al, 2009), although cognitive impairment in the watermaze present after seven consecutive doses of 5 mg/kg LPS was recovered 30 days after treatment in another study (Bian et al, 2013). There are some methodological differences between how the 8-arm radial maze task was run in our study compared to that used by Weberpals et al (2009) -for example differences in number of arms baited and testing at different phases of the light/dark cycle.…”

Section: Persistent Depressive-like and Anxiety-like Behaviours In Secontrasting

confidence: 99%

Lipopolysaccharide-induced sepsis induces long-lasting affective changes in the mouse

Anderson

Commins

Moynagh

et al. 2015

Brain, Behavior, and Immunity

140

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Post-septic encephalopathy is a poorly understood condition in survivors of sepsis that is characterised by cognitive and affective impairments. In this study we have sought to better understand this condition by undertaking a comprehensive behavioural and cognitive assessment of mice who had previously survived sepsis. Mice were treated with lipopolysaccharide (LPS; 5mg/kg) and one month after this assessed on a battery of tests. Post-septic animals were found to display significantly more immobility in the tail suspension test and show a significantly decreased sucrose preference. Acute fluoxetine treatment reversed the increase in immobility in the tail suspension test in post-septic animals. Post-septic animals also showed less overall exploratory behaviour in the novel object recognition task and also showed increased anxiety-like behaviour in the elevated plus maze. Post-septic mice did not show signs of cognitive impairment, as assessed in the Morris watermaze, the 8-arm radial maze or on preference for the novel object in the novel object recognition task. Immunohistochemical analysis revealed significant upregulation of the microglial marker CD-11b, F4/80 and IBA-1 in the hippocampus of post-septic animals, as well as significant downregulation of the plasticity-related immediate early gene products ARC and EGR1. We also observed a decrease in neural stem cell proliferation in the dentate gyrus of post-septic animals as judged by BrdU incorporation. Co-treatment with the NF-κB pathway inhibitor PDTC attenuated the long-lasting effects of LPS on most of the affected parameters, but not on neural stem cell proliferation. These results show that LPS-induced sepsis in the mouse is followed by long-lasting increases in depressive- and anxiety-like behaviours, as well as by changes in neuroinflammatory- and neural plasticity-associated factors, and that attenuation of the severity of sepsis by PDTC attenuates many of these effects.

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Section: Persistent Depressive-like and Anxiety-like Behaviours In Secontrasting

confidence: 99%

Lipopolysaccharide-induced sepsis induces long-lasting affective changes in the mouse

Anderson

Commins

Moynagh

et al. 2015

Brain, Behavior, and Immunity

140

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“…This may relate to the dose of LPS, as chronic administration (daily for 7 days) generated an astrocyte response in another study, whereas in our study only a single LPS administration was employed (Bian et al, 2013). Another possibility is that there is a temporal difference between the reactivity of the two cell types, with microglia responding more quickly to this insult than astrocytes (Kuhlmann and Guilarte, 2000;Ni et al, 2010).…”

Section: Discussionmentioning

confidence: 84%

Effects of Centrally Administered Etanercept on Behavior, Microglia, and Astrocytes in Mice Following a Peripheral Immune Challenge

Camara

Corrigan

Jaehne

et al. 2014

Neuropsychopharmacol

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“…A medium-dose LPS injection (5 mg/kg) reversibly impaired spatial learning and memory. However, the impairments induced by high-dose injections (10 mg/kg) of LPS were irreversible (Bian et al,2013). Physiological parameters such as body weight, blood pressure and heart rate were not influenced in rats that received low-dose LPS injections (Krizak et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Hypoxia augments LPS-induced inflammation and triggers high altitude cerebral edema in mice

Zhou¹,

Huang²,

Zhao³

et al. 2017

Brain, Behavior, and Immunity

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High altitude cerebral edema (HACE) is a life-threatening illness that develops during the rapid ascent to high altitudes, but its underlying mechanisms remain unclear. Growing evidence has implicated inflammation in the susceptibility to and development of brain edema. In the present study, we investigated the inflammatory response and its roles in HACE in mice following high altitude hypoxic injury. We report that acute hypobaric hypoxia induced a slight inflammatory response or brain edema within 24h in mice. However, the lipopolysaccharide (LPS)-induced systemic inflammatory response rapidly aggravated brain edema upon acute hypobaric hypoxia exposure by disrupting blood-brain barrier integrity and activating microglia, increasing water permeability via the accumulation of aquaporin-4 (AQP4), and eventually leading to impaired cognitive and motor function. These findings demonstrate that hypoxia augments LPS-induced inflammation and induces the occurrence and development of cerebral edema in mice at high altitude. Here, we provide new information on the impact of systemic inflammation on the susceptibility to and outcomes of HACE.

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Various roles of astrocytes during recovery from repeated exposure to different doses of lipopolysaccharide

Cited by 25 publications

References 36 publications

Lipopolysaccharide-induced sepsis induces long-lasting affective changes in the mouse

Lipopolysaccharide-induced sepsis induces long-lasting affective changes in the mouse

Effects of Centrally Administered Etanercept on Behavior, Microglia, and Astrocytes in Mice Following a Peripheral Immune Challenge

Hypoxia augments LPS-induced inflammation and triggers high altitude cerebral edema in mice

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