Various Stages of Optic Neuritis Assessed by Subjective Brightness of Flicker

Trauzettel‐Klosinski, Susanne

doi:10.1001/archopht.1989.01070010065029

Cited by 10 publications

(6 citation statements)

References 26 publications

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“…Furthermore, in all 5 ON patients with normal visual acuity, the DFT showed an abnormal response. This is in agreement with the earlier studies with the AFT, where visual acuity could have normalized and the AFT was pathological reflecting the florid stage of the ON [13,22]. Summary statistics are means (SD) and p value for difference according to independent samples t test unless otherwise specified.…”

Section: Discussion/conclusionsupporting

confidence: 89%

“…The AFT exhibited a dynamic pattern during the course of ON, from DE in the florid phase, through the subacute phase (flattening of the curve and a peak at 5-2 Hz), through to normalization or almost normalization of the response after months [13]. Therefore, the AFT was useful for diagnosis, monitoring of the course and for differential diagnosis in atypical cases as well as for diagnosing recurrent attacks after previous normalization.…”

Section: Introductionmentioning

confidence: 98%

“…In normal subjects the perceived brightness of a flickering field at successive frequencies shows a brightness enhancement at 8-10 Hz termed the Brücke-Bartley effect [11,12]. The AFT employs this characteristic to distinguish florid ON from control eyes [13][14][15][16][17][18][19][20][21][22][23][24][25] and from previous ON. Studies showed a sensitivity of 85.5% with a specificity of 97.9% in the Tübingen centre [13,14,22] and in other groups a sensitivity of 23.5-95.8% to a specificity of 83.3-100% [17,21,23,24] depending on the diagnostic criteria.…”

Section: Introductionmentioning

confidence: 99%

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Sensitive Assessment of Acute Optic Neuritis by a New, Digital Flicker Test

et al. 2019

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Background: The Aulhorn flicker test (AFT) previously showed promise in diagnosing acute optic neuritis (ON) albeit with suboptimal sensitivity. A new, digitalized version of the AFT (the DFT) has not previously been examined in acute ON. Objectives: To examine the sensitivity, specificity and reproducibility of the DFT in acute ON. Method: The DFT assesses the subjective brightness of a flickering field (1-60 Hz). In normal subjects, brightness enhancement occurs at intermediate frequencies, whereas in acute ON darkness enhancement (DE) is hypothesized. AFT and DFT measurements were obtained in acute ON patients (≤31 days from first symptom) with DE as a quantitative covariate. Reproducibility of the DFT end point was assessed in the form of an intraclass correlation. Results: 30 untreated first-time acute ON patients and 55 healthy controls were examined. AFT and DFT were performed 12.7 days (range: 4-30) following ON onset. The DFT showed a sensitivity of 0.93 (95% CI = 0.78-0.99) to a specificity of 0.96 (95% CI = 0.87-1.00). The AFT showed a sensitivity of 0.76 (95% CI = 0.56-0.90) to a specificity of 1.00 (95% CI = 0.93-1.00). No significant correlation was shown between DFT and visual acuity. The intraclass correlation of the DFT end point in healthy subjects was 0.84. Conclusions: We present a new DFT in acute ON displaying a high specificity of 0.96 and a sensitivity of 0.93. Our study indicates the DFT to be an accurate and easy-to-use tool in diagnosing acute ON, which may be especially helpful in atypical cases.

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Section: Discussion/conclusionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Sensitive Assessment of Acute Optic Neuritis by a New, Digital Flicker Test

et al. 2019

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“…However, 25 out of 30 tested patients (83%) with recovered optic neuritis showed that mean amplitudes at 2 Hz were larger than those at 10 Hz. Moreover, as described previously, psychophysical studies (Otori et al 1973;Trauzettel-Klosinski 1989;Trauzettel-Klosinski et al 1989;Woung et al 1993) also suggested a shift in the temporal responsivity curve to lower frequencies. Thus, we conclude that higher frequency impairments of the visual system are a feature of eyes with active and recovered optic neuritis.…”

Section: P100 Implicit Timementioning

confidence: 50%

“…Flicker tests also show that patients with optic neuritis have impaired visual responsivity to higher frequency flicker, although their responses were within the normal range at lower flicker frequencies (Trauzettel-Klosinski 1989;Trauzettel-Klosinski et al 1989). Similarly, patients who have recovered from optic neuritis as well as those with optic neuritis have difficulties in detecting high-frequency flicker, and consequently their central critical fusion frequency (CFF) is decreased (Otori et al 1973;Woung et al 1993).…”

Section: Discussionmentioning

confidence: 99%

Shift of temporal responsivity curve of pattern reversal visually evoked potentials to lower frequencies in patients after recovery from optic neuritis

Okuno¹,

Oku²,

Sugasawa³

et al. 2009

Acta Ophthalmologica

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ABSTRACT.Purpose: To investigate the responsivity of the visual system to pattern reversal stimuli of different reversal rates in optic neuritis patients after a full recovery of visual acuity. Methods: Thirty eyes with optic neuritis and 30 eyes of age-matched normal controls were studied. Steady-state pattern reversal visually evoked potentials (P-VEPs) were recorded using reversal rates of 2, 10, 20 and 30 Hz. The relationship between the amplitudes of the P-VEPs and reversal rate was analysed. The temporal responsivity curves of the two groups were compared. Results: The means ± standard deviations (SDs) of the P-VEP amplitudes in the normal controls were 7.08 ± 2.97, 8.60 ± 2.37, 4.69 ± 1.99 and 2.11 ± 1.24 lV at reversal rates of 2, 10, 20 and 30 Hz, respectively. The comparable amplitudes from the recovered optic neuritis patients were 8.01 ± 2.45, 6.57 ± 2.54, 2.73 ± 1.76 and 0.94 ± 1.27 lV. The mean amplitude of the P-VEPs elicited at a reversal rate of 2 Hz was not significantly different from that of normal controls. However, the amplitudes of the P-VEPs at reversal rates of 10, 20 and 30 Hz were significantly smaller in the recovered optic neuritis patients than in the controls. In addition, the average maximum amplitude of the P-VEPs was obtained at 10 Hz in normal subjects and at 2 Hz in the recovered optic neuritis patients. Conclusion: These results indicate that the peak of the temporal tuning curve of the P-VEP shifts to lower frequencies in recovered optic neuritis eyes, and that the reduced amplitudes at higher frequencies seem to be characteristic of the visual system of patients with recovered optic neuritis.Key words: optic neuritis -pattern visually evoked potential -pattern visually evoked response -temporal frequency -temporal responsivity curve

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Optic Neuritis

Chan¹

2014

Optic Nerve Disorders

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Various Stages of Optic Neuritis Assessed by Subjective Brightness of Flicker

Cited by 10 publications

References 26 publications

Sensitive Assessment of Acute Optic Neuritis by a New, Digital Flicker Test

Sensitive Assessment of Acute Optic Neuritis by a New, Digital Flicker Test

Shift of temporal responsivity curve of pattern reversal visually evoked potentials to lower frequencies in patients after recovery from optic neuritis

Optic Neuritis

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