Various types of the pituitary folliculo-stellate cells involving the Siperstein's corticotroph in the normal rats.

Nagata, Michio; Mizunaga, Atushi; Ema, Shoko; Yoshimura, Fujio

doi:10.1507/endocrj1954.27.13

Cited by 14 publications

(7 citation statements)

References 7 publications

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“…Whereas follicular cells form islet-like clusters, FS cells do mainly not appear as a compact group of cells, and are also solitarily distributed. Moreover, FS cells surround large follicles, and not small (pseudo-)lumina as reported for follicular cells [31, 43, 95, 132]. The cytoplasmic extensions of FS cells seem to be longer than the ones described for follicular cells which display only short processes.…”

Section: Pituitary Stem Cells: Support From Topological Morphologmentioning

confidence: 67%

“…Marginal layer cells and follicular cells certainly display some common ultrastructural features such as presence of microfilaments and signs of immaturity, including agranularity, scanty rough endoplasmatic reticulum, and abundant free ribosomes and polysomes. Strictly taken, follicular cells have been defined as small cells of irregular shape that constitute islet-like clusters around petite (pseudo-)lumina in which microvilli are protruded [31, 43, 95, 132]. Mitotic figures are predominantly detected in follicular cells and not in the other cells of the anterior lobe (except marginal cells) [19, 43].…”

Section: Pituitary Stem Cells: Support From Topological Morphologmentioning

confidence: 99%

“…Follicular cells were therefore proposed to represent a stable ‘reserve cell’ pool throughout life. At the periphery of the clusters, so-called ‘ambiguous’ cells with a small number of tiny granules have been detected, suggesting that follicular cells after mitosis migrate to the border of the cluster to granulate, and to eventually transform into acidophils or basophils through an intermediary stage [43, 132]. After Gnx, but not after Tx, follicular cells seem to be activated, including a rise in incidence of clusters.…”

Section: Pituitary Stem Cells: Support From Topological Morphologmentioning

confidence: 99%

“…Nagata et al [132] distinguished five types of FS cells according to granulation pattern of which only the first type appears similar to follicular cells in terms of agranularity and immaturity, although this type already is clearly different in shape and arrangement. Whereas follicular cells form islet-like clusters, FS cells do mainly not appear as a compact group of cells, and are also solitarily distributed.…”

Section: Pituitary Stem Cells: Support From Topological Morphologmentioning

confidence: 99%

“…This challenging but attractive hypothesis is supported by some findings. S100 expression looks to be a mature feature since S100 expression is only detected from P10 in the rat, and secretory granules have been observed in some FS cells that express S100 [97, 109, 132]. S100 + FS cells do not seem to proliferate in the postnatal rat (as analyzed at P15 and P30) and the human pituitary [24], suggesting that S100 is expressed only after mitotic activity of the cells has ceased [99].…”

Section: Pituitary Stem Cells: Support From Topological Morphologmentioning

confidence: 99%

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Stem Cells in the Postnatal Pituitary?

Vankelecom

2007

Neuroendocrinology

108

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Tissue-specific stem cells are uncovered in a growing number of organs by their molecular expression profile and their potential for self-renewal, multipotent differentiation and tissue regeneration. Whether the pituitary gland also contains a pool of versatile ’master’ cells that drive homeostatic, plastic and regenerative cell ontogenesis is at present unknown. Here, I will give an overview of data that may lend support to the existence of stem cells in the postnatal pituitary. During the many decades of pituitary research, various approaches have been used to hunt for the pituitary stem cells. Transplantation and regeneration studies advanced chromophobes as possible source of new hormonal cells. Clonogenicity approaches identified pituitary cells that clonally expand to floating spheres, or to colonies in adherent cell cultures. Behavioural characteristics and changes of marginal, follicular and folliculostellate cells during defined developmental and (patho-)physiological conditions have been interpreted as indicative of a stem cell role. Expression of potential stem cell markers like nestin, as well as topographical localization in the marginal zone around the cleft has also been considered to designate pituitary stem cells. Finally, a ‘side population’ was recently identified in the postnatal pituitary which in many other tissues represents a stem cell-enriched fraction. Taken together, in the course of the long-standing study of the pituitary, several arguments have been presented to support the existence of stem cells, and multiple cell types have been placed in the spotlight as possible candidates. However, none of these cells has until now unequivocally been shown to meet all quintessential characteristics of stem cells.

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Section: Pituitary Stem Cells: Support From Topological Morphologmentioning

confidence: 67%

Section: Pituitary Stem Cells: Support From Topological Morphologmentioning

confidence: 99%

Section: Pituitary Stem Cells: Support From Topological Morphologmentioning

confidence: 99%

Section: Pituitary Stem Cells: Support From Topological Morphologmentioning

confidence: 99%

Section: Pituitary Stem Cells: Support From Topological Morphologmentioning

confidence: 99%

See 3 more Smart Citations

Stem Cells in the Postnatal Pituitary?

Vankelecom

2007

Neuroendocrinology

108

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Facts and hypotheses concerning the function of non‐granulated cells in the adenohypophysis of vertebrates

Harrisson

1988

BioEssays

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SummaryElectron microscopic examination of the non-granulated cells of the adenohypophysis of several species has evidenced a unity of structure amongst vertebrates. Eforts to correlate structure andfunction have been made, but they have often been hampered by the scarcity or absence of direct experimental methods for the investigation of their function. Yet often the evidence in favor of a given role has been circumstantial, relying on coincidences between changes in the secretory activity of the gland and changes in the ultrastructure of the non-granulated cells or in colloid production. At the present time, the prevailing hypothesis is that, in addition to a possible role in mechanical support within the gland, the non-granulated cells seem to be important with respect to the secretory process of the endocrine cells and/or to the metabolism of the adenohypophysis.

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Paracrine Interactions in the Anterior Pituitary

Robberecht¹,

Denef²

1989

Neuroendocrine Perspectives

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Various types of the pituitary folliculo-stellate cells involving the Siperstein's corticotroph in the normal rats.

Cited by 14 publications

References 7 publications

Stem Cells in the Postnatal Pituitary?

Stem Cells in the Postnatal Pituitary?

Facts and hypotheses concerning the function of non‐granulated cells in the adenohypophysis of vertebrates

Paracrine Interactions in the Anterior Pituitary

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