The Vertiskos-Ograzden metamorphic complex (VOC; W-Rhodope Metamorphic Domain, RMD) is a key area for reconstructing the geodynamic history of the Hellenides. We distinguish four metamorphic events: (1) an (U)HP eclogite facies metamorphism, succeeded by partial melting during decompression, amphibolite facies reequilibration in the kyanite stability field, and injection of muscovite pegmatites; (2) a LP-HT event, associated with partial melting within the stability field of sillimanite, cordierite, and K-feldspar (andalusite at subsolidus conditions) and magmatic intrusions; (3) a prograde moderate high-pressure (MHP) metamorphism within the kyanite stability field increasing to the NE from epidote amphibolite to upper amphibolite facies; and (4) in the easternmost VOC, a LP amphibolite facies event (new cordierite and andalusite). Considering existing geochronological data, the VOC formed part of successive tectonic settings: (1) the "Variscan" collision zone between "East-Avalonian" and Armorican continental fragments; (2) the Triassic middle crust of a continental rift zone, (leading to formation of oceanic crust, in the eastern VOC); (3) late Jurassic-early Cretaceous closure of the oceanic basin and accretion of the VOC to southern European margin and northeastward polarity of subduction/collision; (4) late Cretaceous extension and crustal thinning. Then, subduction of the Neo-Tethys and Apulian plate underneath Europe occurred, and the VOC plus the upper units of the RMD were part of the upper (European) plate. Large-scale north dipping low-angle normal detachments exhumed the VOC from the vicinity of a magmatic arc presently situated in the north RMD and Sredna Gora and Strandja zones and drag it into its present position.