Varying impact of patient age on the rising rate of pediatric thyroid cancer: Analysis of NCDB database (2004–2017)

Zhao, Heming; Pickney, Cole; Sarode, Anuja L.; Kim-Mackow, Anne; Wilhelm, Scott M.

doi:10.1016/j.amjsurg.2022.11.030

Cited by 5 publications

(6 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While most of the thyroid nodules detected in this age group are benign, the risk of a nodule >10 mm being malignant is approximately two- to threefold higher in children than in adults (20%–25% vs. 5%–10%) ( 10 , 11 ). Also, epidemiological data indicate that the worldwide incidence of DTC in pediatric patients is rising, this trend substantially mirroring the one reported in the adult population ( 21 – 25 , 28 , 29 , 32 , 33 , 40 , 41 ). In this regard, a recent large population-based registry study focused on the global patterns and trends in the incidence of thyroid cancer in children and adolescents analyzing data from 49 countries and territories worldwide ( 33 ).…”

Section: Discussionmentioning

confidence: 60%

Global incidence and prevalence of differentiated thyroid cancer in childhood: systematic review and meta-analysis

Moleti,

Aversa,

Crisafulli

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

ObjectiveDifferentiated thyroid cancer (DTC) is rare in childhood and adolescence although it represents the most frequent endocrine malignancy in this population. DTC includes both papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC). Most pediatric DTCs are PTCs, while FTCs are rare. To date, no systematic reviews on the global epidemiology of pediatric and adolescent DTC have been published. This systematic review and meta-analysis aims to estimate the overall incidence and prevalence of DTCs in patients aged 0–19 years.MethodsThe systematic research was conducted from January 2000 to December 2021 through MEDLINE via PubMed, Cochrane Library, and Embase databases. Two separate meta-analyses were performed for PTC and FTC.ResultsAfter the selection phase, a total of 15 studies (3,332 screened) met the inclusion criteria and are reported in the present systematic review. Five studies were conducted in Europe, five in North America, two in South America, one in Asia, one reported data for 49 countries and territories across the five continents, and one from both the USA and Africa. Most of the studies (n = 14) reported data obtained from national registries, and only one provided information collected from hospital medical records. Beyond the actual trend over time, our study reported a pooled global incidence rate (IR) of PTC and FTC in the pediatric age of 0.46 (95% CI: 0.33–0.59) and 0.07 (95% CI: 0.02–0.12) per 100,000 person-years, respectively. The highest IRs were recorded among Caucasian girls, and the lowest in black or other races/ethnicities.ConclusionOur data confirm that DTC in the pediatric population is a rare condition. The pooled IRs of the studies included in this meta-analysis are ~0.5 for PTC, which is the most common histological type when both genders and all age groups are considered. The implementation of a prospective international registry on pediatric DTC, as part of the wider European Registries for Rare Endocrine Conditions, has been recently proposed. In addition to providing relevant information on the clinical behavior of this rare disease, standardization of data collection will be pivotal to fill current gaps and allow an accurate estimation of the real incidence and risk factors of DTC.

show abstract

Section: Discussionmentioning

confidence: 60%

Global incidence and prevalence of differentiated thyroid cancer in childhood: systematic review and meta-analysis

Moleti,

Aversa,

Crisafulli

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…However, recent studies have revealed that disease characteristics and outcomes of PTC can vary significantly based on factors such as age and sex. 3,9,10,17,18 The study found that male patients under the age of 40 exhibited significantly higher lymph node involvement compared to all other sexes and age groups and required both central and lateral neck dissections. Specifically, patients under the age of 40 exhibited higher N1b metastasis compared to their female counterparts of all ages and older male patients.…”

Section: Discussionmentioning

confidence: 95%

“…Historically, PTC has been considered a relatively indolent and low‐risk cancer with excellent long‐term survival rates. However, recent studies have revealed that disease characteristics and outcomes of PTC can vary significantly based on factors such as age and sex 3,9,10,17,18 …”

Section: Discussionmentioning

confidence: 99%

“…Males have worse outcomes, particularly with more advanced disease and aggressive subtypes. [8][9][10] Men are usually diagnosed at an older age and experience shorter disease-free survival. In contrast, women have a sharp increase in incidence rates at the beginning of reproductive years, peaking at 40-49 years, while men peak at 60-69 years.…”

Section: Introductionmentioning

confidence: 99%

“…However, the disease tends to be more aggressive in men. Males have worse outcomes, particularly with more advanced disease and aggressive subtypes 8–10 . Men are usually diagnosed at an older age and experience shorter disease‐free survival.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Young and resilient: Unraveling papillary thyroid cancer outcomes in males under 40

Hood,

Zmijewski,

McLeod

et al. 2024

World j. surg.

View full text Add to dashboard Cite

BackgroundWhile males present with more adverse clinicopathologic features in papillary thyroid carcinoma (PTC), younger age has previously been shown to be a favorable prognostic factor. We examined the combined effect of male sex and young age on PTC outcomes.MethodsWe conducted a retrospective analysis of a prospectively maintained database of thyroid cancer surgery patients (2000–2020) at a single quaternary care institution. We included papillary thyroid carcinoma cases and excluded those with prior cancer‐related thyroid surgery. We examined demographics, cancer stage, surgical outcomes, and complications by age and sex, analyzing groups below and above the age of 40 years.ResultsA total of 680 patients with PTC were included. Females constituted 68% (age ≥40 years: 44% and <40 years: 24%) and males 32% (≥40 years: 24% and <40 years: 8%). A significant difference (p < 0.001) of N1 disease distribution was found between the groups. N1a metastasis was greater in patients younger than 40 regardless of sex ((M < 40 (15%), F < 40 (15%), M ≥ 40 (12%), and F ≥ 40 (9%)). While, M < 40 had greater N1b metastasis (36%) than all other groups (M ≥ 40 (28%), F < 40 (22%), and F ≥ 40 (10%)). There was no significant difference in the distribution of T stages between groups. Groups showed no differences in 30‐day outcomes, recurrence at 1 year, reoperation, mortality, nerve injury, or hypocalcemia.ConclusionsYoung males with PTC face increased occurrence of nodal metastasis yet experience similar recurrence rates as their female and older counterparts. Subgroup analysis underscores the predictive role of sex and age in advanced PTC cases.

show abstract

Narrative overview of possible preventive measures for differentiated thyroid carcinomas

Castro,

Cunha,

Ward

2025

Heliyon

View full text Add to dashboard Cite

Varying impact of patient age on the rising rate of pediatric thyroid cancer: Analysis of NCDB database (2004–2017)

Cited by 5 publications

References 14 publications

Global incidence and prevalence of differentiated thyroid cancer in childhood: systematic review and meta-analysis

Global incidence and prevalence of differentiated thyroid cancer in childhood: systematic review and meta-analysis

Young and resilient: Unraveling papillary thyroid cancer outcomes in males under 40

Narrative overview of possible preventive measures for differentiated thyroid carcinomas

Contact Info

Product

Resources

About